Synthesis of ( R)-(−)-argentilactone

A synthesis of ( R)-(−)-argentilactone is reported starting from the ( S)-enantiomer of glycidol. The synthesis is based on ring closing metathesis of the acrylic ester of ( R)-1- O-( tert-butyldiphenylsilyl)-4-penten-1,2-diol 4. Graphic

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 13; no. 5; pp. 547 - 550
Main Author Hansen, Trond Vidar
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 05.04.2002
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
ROUTE
ENANTIOSELECTIVE SYNTHESIS
ARGENTILACTONE
LACTONES
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Summary:A synthesis of ( R)-(−)-argentilactone is reported starting from the ( S)-enantiomer of glycidol. The synthesis is based on ring closing metathesis of the acrylic ester of ( R)-1- O-( tert-butyldiphenylsilyl)-4-penten-1,2-diol 4. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(02)00138-6