Evaluation of the expression of fibrosis-related genes as non-invasive diagnostic biomarkers for cirrhotic HCV-infected patients

• Published in: Cytokine (Philadelphia, Pa.) Vol. 182; p. 156714
• Main Authors: El-Meguid, Mai Abd, Lotaif, Lotaif Mostafa, Salum, Ghada M., Fotouh, Basma E., Salama, Rabab Maamoun, Salem, Mohamed Ibrahim Seif Elnasr, El Awady, Mostafa K., Abdel Aziz, Ashraf Omar, Dawood, Reham M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2024
• Subjects: Adult; Biomarkers - blood; Biomarkers - metabolism; Cirrhosis; Cross-Sectional Studies; Cytokines; Cytokines - blood; Cytokines - genetics; Female; Gene expression; Gene Expression Regulation; HCV; Hepacivirus; Hepatitis C - complications; Hepatitis C - diagnosis; Hepatitis C - genetics; Humans; Leukocytes, Mononuclear - metabolism; Liver Cirrhosis - blood; Liver Cirrhosis - diagnosis; Liver Cirrhosis - genetics; Liver Cirrhosis - virology; Male; Middle Aged; PBMCs; Transforming Growth Factor beta1 - blood; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta2 - genetics; Cirrhosis; HCV; Cytokines; Gene expression; PBMCs

•Liver cirrhosis triggers architectural disruption and chronic inflammation.•Early detection of cirrhosis is mandatory to minimize the mortality risk.•TGFβ signaling pathway is a pillar regulator in liver cirrhosis.•TGFβ1and TGFβ2 genes are correlated with advanced cirrhosis.•TGFβ2 proteomic level i...