The combined diagnostic value of 5-hmC and PRAME immunohistochemistry in melanocytic neoplasms

• Published in: Pathology, research and practice Vol. 270; p. 155993
• Main Authors: Yu, Yanhong, Hosseini, Niloufar, Dodington, David, Wood, Kimberly, Ghazarian, Danny, Kamil, Zaid Saeed
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.06.2025
• Subjects: 5-hydroxymethylcytosine; 5-Methylcytosine - analogs & derivatives; Adolescent; Adult; Aged; Antigens, Neoplasm - analysis; Antigens, Neoplasm - metabolism; Biomarkers, Tumor - analysis; Diagnosis, Differential; Dysplastic Nevus Syndrome - diagnosis; Dysplastic Nevus Syndrome - metabolism; Dysplastic Nevus Syndrome - pathology; Female; Humans; Immunohistochemistry; Male; Melanoma; Melanoma - diagnosis; Melanoma - metabolism; Melanoma - pathology; Middle Aged; Nevus; Nevus, Epithelioid and Spindle Cell - diagnosis; Nevus, Epithelioid and Spindle Cell - metabolism; Nevus, Epithelioid and Spindle Cell - pathology; PReferentially expressed Antigen in MElanoma; Retrospective Studies; Skin Neoplasms - diagnosis; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Young Adult; Immunohistochemistry; PReferentially expressed Antigen in MElanoma; 5-hydroxymethylcytosine; Melanoma; Nevus

The diagnosis of melanocytic neoplasms, particularly those with borderline morphologic features, remains a challenging area in dermatopathology. 5-hydroxymethylcytosine (5-hmC) and PRAME (PReferentially expressed Antigen in MElanoma) are recent immunohistochemical markers which have been shown to be...