Physiologically-based modeling of methylprednisolone pharmacokinetics across species with extrapolations to humans

• Published in: Journal of pharmaceutical sciences Vol. 114; no. 5; p. 103719
• Main Authors: Yu, Ruihong, Jusko, William J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2025
• Subjects: Animals; Anti-Inflammatory Agents - blood; Anti-Inflammatory Agents - pharmacokinetics; Clearance; Human extrapolation; Humans; Methylprednisolone; Methylprednisolone - blood; Methylprednisolone - pharmacokinetics; Models, Biological; Pharmacokinetics; Rats; Species scaling; Species Specificity; Tissue Distribution; Species scaling; Clearance; Methylprednisolone; Pharmacokinetics; Human extrapolation

•This study characterized and parameterized the allometric scaling relationships of methylprednisolone (MPL) pharmacokinetics (PK) across seven species, revealing an allometric exponent of approximately 1.0 for clearances.•A series of physiologically based pharmacokinetic (PBPK) –basic, intermediate...