Plasma bile acid profile analysis by liquid chromatography-tandem mass spectrometry and its application in healthy subjects and IBD patients

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 255; p. 116639
• Main Authors: Gong, Xuepeng, Liu, Dong, Liu, Lu, Yang, Guangjie, Lei, Yongfang, Li, NingHong, Chen, Yufei, Yu, Hengyi, Li, Xiping, Xiang, Dong
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.03.2025
• Subjects: Adult; Bile acid profile; Bile Acids and Salts - blood; Biomarkers - blood; Chromatography, High Pressure Liquid - methods; Chromatography, Liquid - methods; Female; Healthy Volunteers; Humans; Inflammatory bowel disease; Inflammatory Bowel Diseases - blood; Inflammatory Bowel Diseases - diagnosis; LC-MS/MS; Limit of Detection; Male; Middle Aged; Plasma; Reproducibility of Results; Tandem Mass Spectrometry - methods; Inflammatory bowel disease; LC-MS/MS; Plasma; Bile acid profile

Bile acids (BAs), not only promote the absorption of fat-soluble nutrients and regulate the metabolism of multiple substances but also have a potential role as diagnostic and prognostic indicators in a variety of diseases such as cholestasis, hepatocellular carcinoma, and diabetes mellitus. Here, a...