Spinal Metastases from Colorectal Cancer at Mass General Brigham: A Twenty-Year Case Series With Literature Review
We present an institutional case series of patients treated for colorectal carcinoma (CRC) spinal metastases to investigate the outcomes between no treatment, radiation, surgery, and surgery/radiation. A retrospective cohort of patients with CRC spinal metastases presenting to affiliated institution...
Saved in:
Published in | World neurosurgery Vol. 176; pp. e246 - e253 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.08.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | We present an institutional case series of patients treated for colorectal carcinoma (CRC) spinal metastases to investigate the outcomes between no treatment, radiation, surgery, and surgery/radiation.
A retrospective cohort of patients with CRC spinal metastases presenting to affiliated institutions between 2001 and 2021 wereidentified. Information related to patient demographics, treatment modality, treatment outcomes, symptom improvement, and survival was collected by chart review. Overall survival (OS) was compared between treatments by log-rank significance testing. A literature review was conducted to identify other cases series of CRC patients with spinal metastases.
Eighty-nine patients (mean age 58.5) with CRC spinal metastases across a mean of 3.3 levels met inclusion criteria: 14 (15.7%) received no treatment, 11 (12.4%) received surgery alone, 37 (41.6%) received radiation alone, and 27 (30.3%) received both radiation and surgery. Patients treated with combination therapy had the longest median OS of 24.7 months (range 0.6–85.9), which did not significantly differ from the median OS of 8.9 months (range 0.2–42.6) observed in patients who received no treatment (P = 0.075). Combination therapy provided objectively longer survival time in comparison to other treatment modalities but failed to reach statistical significance. The majority of patients that received treatment (n = 51/75, 68.0%) experienced some degree of symptomatic or functional improvement.
Therapeutic intervention has the potential to improve the quality of life in patients with CRC spinal metastases. We demonstrate that surgery and radiation are useful options for these patients, despite their lack of objective improvement in OS. |
---|---|
AbstractList | We present an institutional case series of patients treated for colorectal carcinoma (CRC) spinal metastases to investigate the outcomes between no treatment, radiation, surgery, and surgery/radiation.OBJECTIVEWe present an institutional case series of patients treated for colorectal carcinoma (CRC) spinal metastases to investigate the outcomes between no treatment, radiation, surgery, and surgery/radiation.A retrospective cohort of patients with CRC spinal metastases presenting to affiliated institutions between 2001 and 2021 wereidentified. Information related to patient demographics, treatment modality, treatment outcomes, symptom improvement, and survival was collected by chart review. Overall survival (OS) was compared between treatments by log-rank significance testing. A literature review was conducted to identify other cases series of CRC patients with spinal metastases.METHODSA retrospective cohort of patients with CRC spinal metastases presenting to affiliated institutions between 2001 and 2021 wereidentified. Information related to patient demographics, treatment modality, treatment outcomes, symptom improvement, and survival was collected by chart review. Overall survival (OS) was compared between treatments by log-rank significance testing. A literature review was conducted to identify other cases series of CRC patients with spinal metastases.Eighty-nine patients (mean age 58.5) with CRC spinal metastases across a mean of 3.3 levels met inclusion criteria: 14 (15.7%) received no treatment, 11 (12.4%) received surgery alone, 37 (41.6%) received radiation alone, and 27 (30.3%) received both radiation and surgery. Patients treated with combination therapy had the longest median OS of 24.7 months (range 0.6-85.9), which did not significantly differ from the median OS of 8.9 months (range 0.2-42.6) observed in patients who received no treatment (P = 0.075). Combination therapy provided objectively longer survival time in comparison to other treatment modalities but failed to reach statistical significance. The majority of patients that received treatment (n = 51/75, 68.0%) experienced some degree of symptomatic or functional improvement.RESULTSEighty-nine patients (mean age 58.5) with CRC spinal metastases across a mean of 3.3 levels met inclusion criteria: 14 (15.7%) received no treatment, 11 (12.4%) received surgery alone, 37 (41.6%) received radiation alone, and 27 (30.3%) received both radiation and surgery. Patients treated with combination therapy had the longest median OS of 24.7 months (range 0.6-85.9), which did not significantly differ from the median OS of 8.9 months (range 0.2-42.6) observed in patients who received no treatment (P = 0.075). Combination therapy provided objectively longer survival time in comparison to other treatment modalities but failed to reach statistical significance. The majority of patients that received treatment (n = 51/75, 68.0%) experienced some degree of symptomatic or functional improvement.Therapeutic intervention has the potential to improve the quality of life in patients with CRC spinal metastases. We demonstrate that surgery and radiation are useful options for these patients, despite their lack of objective improvement in OS.CONCLUSIONSTherapeutic intervention has the potential to improve the quality of life in patients with CRC spinal metastases. We demonstrate that surgery and radiation are useful options for these patients, despite their lack of objective improvement in OS. We present an institutional case series of patients treated for colorectal carcinoma (CRC) spinal metastases to investigate the outcomes between no treatment, radiation, surgery, and surgery/radiation. A retrospective cohort of patients with CRC spinal metastases presenting to affiliated institutions between 2001 and 2021 wereidentified. Information related to patient demographics, treatment modality, treatment outcomes, symptom improvement, and survival was collected by chart review. Overall survival (OS) was compared between treatments by log-rank significance testing. A literature review was conducted to identify other cases series of CRC patients with spinal metastases. Eighty-nine patients (mean age 58.5) with CRC spinal metastases across a mean of 3.3 levels met inclusion criteria: 14 (15.7%) received no treatment, 11 (12.4%) received surgery alone, 37 (41.6%) received radiation alone, and 27 (30.3%) received both radiation and surgery. Patients treated with combination therapy had the longest median OS of 24.7 months (range 0.6–85.9), which did not significantly differ from the median OS of 8.9 months (range 0.2–42.6) observed in patients who received no treatment (P = 0.075). Combination therapy provided objectively longer survival time in comparison to other treatment modalities but failed to reach statistical significance. The majority of patients that received treatment (n = 51/75, 68.0%) experienced some degree of symptomatic or functional improvement. Therapeutic intervention has the potential to improve the quality of life in patients with CRC spinal metastases. We demonstrate that surgery and radiation are useful options for these patients, despite their lack of objective improvement in OS. |
Author | Lee, Suk Joon Zaidi, Hasan A. Chalif, Joshua I. McNulty, Jack J. Klinger, Neil V. Yearley, Alexander G. Chalif, Eric J. |
Author_xml | – sequence: 1 givenname: Alexander G. orcidid: 0000-0001-9592-8263 surname: Yearley fullname: Yearley, Alexander G. organization: Harvard Medical School, Boston, Massachusetts, USA – sequence: 2 givenname: Jack J. surname: McNulty fullname: McNulty, Jack J. organization: Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA – sequence: 3 givenname: Eric J. orcidid: 0000-0002-7313-8188 surname: Chalif fullname: Chalif, Eric J. organization: George Washington University, School of Medicine and Health Sciences, Washington, District of Columbia, USA – sequence: 4 givenname: Joshua I. surname: Chalif fullname: Chalif, Joshua I. organization: Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA – sequence: 5 givenname: Suk Joon orcidid: 0000-0002-4719-5824 surname: Lee fullname: Lee, Suk Joon organization: Harvard Medical School, Boston, Massachusetts, USA – sequence: 6 givenname: Neil V. orcidid: 0000-0003-1219-1601 surname: Klinger fullname: Klinger, Neil V. organization: Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA – sequence: 7 givenname: Hasan A. surname: Zaidi fullname: Zaidi, Hasan A. email: hzaidi1@bwh.harvard.edu organization: Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37207725$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kF1LwzAUhoMozo_9AS8kl960Jk3TpOKNDr9gQ3CKeBXS9lQz-jGT1LF_b8bUS0MgIec5LznPIdrt-g4QOqEkpoRm54t41cEQJyRhMeExSfkOOqBSyEiKLN_9u3MyQmPnFiQsRlMp2D4aMZEQIRJ-gOx8aTrd4Bl47cIGh2vbt3jSN72F0ofSRHclWKw9nmnn8B10YMPztTXvH7q9wFf4eQWdX0dvoG2gHeA5WBOSXo3_wFPjA-8HC_gJvgysjtFerRsH45_zCL3c3jxP7qPp493D5GoalYwIH_GUluGLnBU1kYIyISRAlsk8JbnMC050KIgEElbkoqB5WrEcyozwHJjgjLEjdLbNXdr-cwDnVWtcCU2jO-gHpxJJM5FxymlAky1a2t45C7VaWtNqu1aUqI1utVAb3WqjWxGugu7QdPqTPxQtVH8tv3IDcLkFIEwZJrfKlQaCzMps1KqqN__lfwPX7JFT |
Cites_doi | 10.1007/s00268-015-3296-x 10.3748/wjg.v21.i41.11767 10.1186/s12957-018-1439-x 10.1097/00007632-200102010-00016 10.1016/j.jocn.2015.10.005 10.1007/s10585-019-09987-w 10.1097/00000658-194007000-00016 10.1097/00007632-199011010-00005 10.1634/theoncologist.2012-0293 10.4184/asj.2014.8.3.267 10.14245/ns.2244290.145 10.1016/S0140-6736(05)66954-1 10.1227/NEU.0b013e318207780c 10.1302/0301-620X.101B11.BJJ-2018-1600.R2 10.1016/j.clcc.2017.11.003 10.1097/BSD.0000000000001152 10.1016/S0936-6555(05)80493-5 10.1007/s00586-019-05879-5 10.1055/s-0029-1242458 10.1023/A:1006312306713 10.1186/s13014-017-0852-6 |
ContentType | Journal Article |
Copyright | 2023 Elsevier Inc. Copyright © 2023 Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: 2023 Elsevier Inc. – notice: Copyright © 2023 Elsevier Inc. All rights reserved. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.wneu.2023.05.045 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1878-8769 |
EndPage | e253 |
ExternalDocumentID | 10_1016_j_wneu_2023_05_045 37207725 S1878875023006800 |
Genre | Journal Article Review |
GroupedDBID | --- --K --M .1- .FO .~1 0R~ 1B1 1P~ 1~. 1~5 4.4 457 4G. 53G 5VS 7-5 71M 8P~ 9JM AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAXLA AAXUO ABBQC ABCQJ ABFNM ABFRF ABJNI ABLJU ABLVK ABMAC ABMZM ABXDB ABYKQ ACDAQ ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AEVXI AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV EBS EFJIC EFLBG EJD EP3 F5P FDB FEDTE FIRID FNPLU FYGXN GBLVA HVGLF HZ~ J1W KOM LCYCR M41 MO0 MOBAO N9A O-L O9- OAUVE OQ- OZT P-8 P-9 PC. PG~ Q38 RIG ROL SCC SDF SDP SEL SES SPCBC SSH SSN SSZ T5K Z5R ~G- AAXKI AFCTW AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c307t-541c72553bf08713778ee668940989b50abf072e23b97b194d39ec6059e375333 |
IEDL.DBID | AIKHN |
ISSN | 1878-8750 1878-8769 |
IngestDate | Sat Aug 17 04:42:01 EDT 2024 Thu Sep 26 16:20:11 EDT 2024 Wed Oct 02 05:29:38 EDT 2024 Fri Feb 23 02:35:52 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Spinal metastasis RT OS Tx Colorectal cancer Case series Neurosurgery IQR KPS mRS UE SD Dx CRC LE |
Language | English |
License | Copyright © 2023 Elsevier Inc. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c307t-541c72553bf08713778ee668940989b50abf072e23b97b194d39ec6059e375333 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ORCID | 0000-0003-1219-1601 0000-0001-9592-8263 0000-0002-4719-5824 0000-0002-7313-8188 |
PMID | 37207725 |
PQID | 2816765151 |
PQPubID | 23479 |
ParticipantIDs | proquest_miscellaneous_2816765151 crossref_primary_10_1016_j_wneu_2023_05_045 pubmed_primary_37207725 elsevier_sciencedirect_doi_10_1016_j_wneu_2023_05_045 |
PublicationCentury | 2000 |
PublicationDate | August 2023 2023-08-00 20230801 |
PublicationDateYYYYMMDD | 2023-08-01 |
PublicationDate_xml | – month: 08 year: 2023 text: August 2023 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | World neurosurgery |
PublicationTitleAlternate | World Neurosurg |
PublicationYear | 2023 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Brown, Stafford, Schild, Martenson, Schiff (bib10) 1999; 44 Park, Park, Nam, Lee (bib6) 2022; 35 Baek, Hur, Min, Baik, Lee, Kim (bib3) 2016; 40 Tokuhashi, Matsuzaki, Toriyama, Kawano, Ohsaka (bib22) 1990; 15 Di Perna, Cofano, Mantovani (bib25) 2020; 25 Patchell, Tibbs, Regine (bib19) 2005; 366 Geh, Glynne-Jones (bib9) 1998; 10 Ziu, Viswanathan, Mesfin (bib14) 2022 Leach, Lau, La Marca, Park (bib7) 2014; 8 Maccauro, Spinelli, Mauro, Perisano, Graci, Rosa (bib16) 2011; 2011 Uei, Tokuhashi (bib23) 2018; 16 Haggar, Boushey (bib26) 2009; 22 Tomita, Kawahara, Kobayashi, Yoshida, Murakami, Akamaru (bib21) 2001; 26 Park, Park, Lee (bib12) 2019; 101-B Taylor, Karlin, Halfdanarson, Coppola, Grothey (bib5) 2018; 17 Fomchenko, Bayley, Alvarez-Breckenridge, Rhines, Tatsui (bib27) 2022; 19 Rawla, Sunkara, Barsouk (bib1) 2019; 14 Vatandoust, Price, Karapetis (bib2) 2015; 21 Liu, Yang, Li (bib24) 2019; 28 Arrigo, Kalanithi, Cheng (bib11) 2011; 68 Onken, Fekonja, Wehowsky, Hubertus, Vajkoczy (bib15) 2019; 36 Goodwin, Sankey, Liu (bib8) 2016; 25 (bib13) 2008 Bostel, Förster, Schlampp (bib4) 2017; 12 Batson (bib17) 1940; 112 Togawa, Lewandrowski (bib18) 2006 Laufer, Rubin, Lis (bib20) 2013; 18 Togawa (10.1016/j.wneu.2023.05.045_bib18) 2006 Geh (10.1016/j.wneu.2023.05.045_bib9) 1998; 10 Liu (10.1016/j.wneu.2023.05.045_bib24) 2019; 28 Ziu (10.1016/j.wneu.2023.05.045_bib14) 2022 Onken (10.1016/j.wneu.2023.05.045_bib15) 2019; 36 Bostel (10.1016/j.wneu.2023.05.045_bib4) 2017; 12 Fomchenko (10.1016/j.wneu.2023.05.045_bib27) 2022; 19 Tomita (10.1016/j.wneu.2023.05.045_bib21) 2001; 26 Tokuhashi (10.1016/j.wneu.2023.05.045_bib22) 1990; 15 Taylor (10.1016/j.wneu.2023.05.045_bib5) 2018; 17 Park (10.1016/j.wneu.2023.05.045_bib6) 2022; 35 Leach (10.1016/j.wneu.2023.05.045_bib7) 2014; 8 Arrigo (10.1016/j.wneu.2023.05.045_bib11) 2011; 68 Maccauro (10.1016/j.wneu.2023.05.045_bib16) 2011; 2011 Vatandoust (10.1016/j.wneu.2023.05.045_bib2) 2015; 21 Brown (10.1016/j.wneu.2023.05.045_bib10) 1999; 44 Patchell (10.1016/j.wneu.2023.05.045_bib19) 2005; 366 Park (10.1016/j.wneu.2023.05.045_bib12) 2019; 101-B Rawla (10.1016/j.wneu.2023.05.045_bib1) 2019; 14 Haggar (10.1016/j.wneu.2023.05.045_bib26) 2009; 22 (10.1016/j.wneu.2023.05.045_bib13) 2008 Batson (10.1016/j.wneu.2023.05.045_bib17) 1940; 112 Uei (10.1016/j.wneu.2023.05.045_bib23) 2018; 16 Di Perna (10.1016/j.wneu.2023.05.045_bib25) 2020; 25 Baek (10.1016/j.wneu.2023.05.045_bib3) 2016; 40 Goodwin (10.1016/j.wneu.2023.05.045_bib8) 2016; 25 Laufer (10.1016/j.wneu.2023.05.045_bib20) 2013; 18 |
References_xml | – volume: 366 start-page: 643 year: 2005 end-page: 648 ident: bib19 article-title: Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial publication-title: Lancet contributor: fullname: Regine – volume: 35 start-page: E187 year: 2022 end-page: E193 ident: bib6 article-title: Characteristics of patients undergoing surgical treatment for spinal metastases from colorectal cancer: a comparison with non-small cell lung cancer publication-title: Clin Spine Surg contributor: fullname: Lee – volume: 22 start-page: 191 year: 2009 end-page: 197 ident: bib26 article-title: Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors publication-title: Clin Colon Rectal Surg contributor: fullname: Boushey – volume: 15 start-page: 1110 year: 1990 end-page: 1113 ident: bib22 article-title: Scoring system for the preoperative evaluation of metastatic spine tumor prognosis publication-title: Spine (Phila Pa 1976) contributor: fullname: Ohsaka – volume: 21 start-page: 11767 year: 2015 end-page: 11776 ident: bib2 article-title: Colorectal cancer: metastases to a single organ publication-title: World J Gastroenterol contributor: fullname: Karapetis – volume: 14 start-page: 89 year: 2019 end-page: 103 ident: bib1 article-title: Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors publication-title: Prz Gastroenterol contributor: fullname: Barsouk – volume: 36 start-page: 493 year: 2019 end-page: 498 ident: bib15 article-title: Metastatic dissemination patterns of different primary tumors to the spine and other bones publication-title: Clin Exp Metastasis contributor: fullname: Vajkoczy – volume: 8 start-page: 267 year: 2014 end-page: 272 ident: bib7 article-title: Outcomes after surgery for spinal metastasis of colorectal origin: case series publication-title: Asian Spine J contributor: fullname: Park – volume: 26 start-page: 298 year: 2001 end-page: 306 ident: bib21 article-title: Surgical strategy for spinal metastases publication-title: Spine (Phila Pa 1976) contributor: fullname: Akamaru – volume: 18 start-page: 744 year: 2013 end-page: 751 ident: bib20 article-title: The NOMS framework: approach to the treatment of spinal metastatic tumors publication-title: Oncologist contributor: fullname: Lis – year: 2008 ident: bib13 article-title: Guidelines. Metastatic Spinal Cord Compression: Diagnosis and Management of Patients at Risk of or with Metastatic Spinal Cord Compression – volume: 68 start-page: 674 year: 2011 end-page: 681 ident: bib11 article-title: Predictors of survival after surgical treatment of spinal metastasis publication-title: Neurosurgery contributor: fullname: Cheng – volume: 112 start-page: 138 year: 1940 end-page: 149 ident: bib17 article-title: The function of the vertebral veins and their role in the spread of metastases publication-title: Ann Surg contributor: fullname: Batson – volume: 101-B start-page: 1379 year: 2019 end-page: 1384 ident: bib12 article-title: Incidence and prognosis of patients with spinal metastasis as the initial manifestation of malignancy: analysis of 338 patients undergoing surgical treatment publication-title: Bone Joint J contributor: fullname: Lee – volume: 2011 start-page: 107969 year: 2011 ident: bib16 article-title: Physiopathology of spine metastasis publication-title: Int J Surg Oncol contributor: fullname: Rosa – start-page: 17 year: 2006 end-page: 23 ident: bib18 article-title: The pathophysiology of spinal metastases publication-title: Cancer in the Spine: Comprehensive Care contributor: fullname: Lewandrowski – volume: 19 start-page: 978 year: 2022 end-page: 993 ident: bib27 article-title: Spinal metastases and the evolving role of molecular targeted therapy, chemotherapy, and immunotherapy publication-title: Neurospine contributor: fullname: Tatsui – volume: 16 start-page: 131 year: 2018 ident: bib23 article-title: Prognostic factors in patients with metastatic spine tumors derived from lung cancer-a novel scoring system for predicting life expectancy publication-title: World J Surg Oncol contributor: fullname: Tokuhashi – volume: 28 start-page: 1491 year: 2019 end-page: 1501 ident: bib24 article-title: Development of a novel model for predicting survival of patients with spine metastasis from colorectal cancer publication-title: Eur Spine J contributor: fullname: Li – volume: 25 start-page: 100320 year: 2020 ident: bib25 article-title: Separation surgery for metastatic epidural spinal cord compression: a qualitative review publication-title: J Bone Oncol contributor: fullname: Mantovani – volume: 40 start-page: 982 year: 2016 end-page: 986 ident: bib3 article-title: The characteristics of bone metastasis in patients with colorectal cancer: a long-term report from a single institution publication-title: World J Surg contributor: fullname: Kim – volume: 12 start-page: 115 year: 2017 ident: bib4 article-title: Spinal bone metastases in colorectal cancer: a retrospective analysis of stability, prognostic factors and survival after palliative radiotherapy publication-title: Radiat Oncol contributor: fullname: Schlampp – volume: 10 start-page: 125 year: 1998 end-page: 128 ident: bib9 article-title: Cervical spine involvement in metastatic colorectal carcinoma publication-title: Clin Oncol contributor: fullname: Glynne-Jones – year: 2022 ident: bib14 article-title: Spinal Metastasis. StatPearls contributor: fullname: Mesfin – volume: 44 start-page: 175 year: 1999 end-page: 180 ident: bib10 article-title: Metastatic spinal cord compression in patients with colorectal cancer publication-title: J Neurooncol contributor: fullname: Schiff – volume: 17 start-page: e183 year: 2018 end-page: e187 ident: bib5 article-title: Leptomeningeal carcinomatosis in colorectal cancer: the mayo clinic experience publication-title: Clin Colorectal Cancer contributor: fullname: Grothey – volume: 25 start-page: 84 year: 2016 end-page: 89 ident: bib8 article-title: Primary lesion location influences postoperative survival in patients with metastatic colorectal spinal lesions publication-title: J Clin Neurosci contributor: fullname: Liu – volume: 25 start-page: 100320 year: 2020 ident: 10.1016/j.wneu.2023.05.045_bib25 article-title: Separation surgery for metastatic epidural spinal cord compression: a qualitative review publication-title: J Bone Oncol contributor: fullname: Di Perna – volume: 40 start-page: 982 year: 2016 ident: 10.1016/j.wneu.2023.05.045_bib3 article-title: The characteristics of bone metastasis in patients with colorectal cancer: a long-term report from a single institution publication-title: World J Surg doi: 10.1007/s00268-015-3296-x contributor: fullname: Baek – volume: 21 start-page: 11767 year: 2015 ident: 10.1016/j.wneu.2023.05.045_bib2 article-title: Colorectal cancer: metastases to a single organ publication-title: World J Gastroenterol doi: 10.3748/wjg.v21.i41.11767 contributor: fullname: Vatandoust – volume: 16 start-page: 131 year: 2018 ident: 10.1016/j.wneu.2023.05.045_bib23 article-title: Prognostic factors in patients with metastatic spine tumors derived from lung cancer-a novel scoring system for predicting life expectancy publication-title: World J Surg Oncol doi: 10.1186/s12957-018-1439-x contributor: fullname: Uei – volume: 26 start-page: 298 year: 2001 ident: 10.1016/j.wneu.2023.05.045_bib21 article-title: Surgical strategy for spinal metastases publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-200102010-00016 contributor: fullname: Tomita – volume: 25 start-page: 84 year: 2016 ident: 10.1016/j.wneu.2023.05.045_bib8 article-title: Primary lesion location influences postoperative survival in patients with metastatic colorectal spinal lesions publication-title: J Clin Neurosci doi: 10.1016/j.jocn.2015.10.005 contributor: fullname: Goodwin – year: 2022 ident: 10.1016/j.wneu.2023.05.045_bib14 contributor: fullname: Ziu – volume: 36 start-page: 493 year: 2019 ident: 10.1016/j.wneu.2023.05.045_bib15 article-title: Metastatic dissemination patterns of different primary tumors to the spine and other bones publication-title: Clin Exp Metastasis doi: 10.1007/s10585-019-09987-w contributor: fullname: Onken – volume: 112 start-page: 138 year: 1940 ident: 10.1016/j.wneu.2023.05.045_bib17 article-title: The function of the vertebral veins and their role in the spread of metastases publication-title: Ann Surg doi: 10.1097/00000658-194007000-00016 contributor: fullname: Batson – volume: 15 start-page: 1110 year: 1990 ident: 10.1016/j.wneu.2023.05.045_bib22 article-title: Scoring system for the preoperative evaluation of metastatic spine tumor prognosis publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-199011010-00005 contributor: fullname: Tokuhashi – volume: 18 start-page: 744 year: 2013 ident: 10.1016/j.wneu.2023.05.045_bib20 article-title: The NOMS framework: approach to the treatment of spinal metastatic tumors publication-title: Oncologist doi: 10.1634/theoncologist.2012-0293 contributor: fullname: Laufer – volume: 8 start-page: 267 year: 2014 ident: 10.1016/j.wneu.2023.05.045_bib7 article-title: Outcomes after surgery for spinal metastasis of colorectal origin: case series publication-title: Asian Spine J doi: 10.4184/asj.2014.8.3.267 contributor: fullname: Leach – volume: 14 start-page: 89 year: 2019 ident: 10.1016/j.wneu.2023.05.045_bib1 article-title: Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors publication-title: Prz Gastroenterol contributor: fullname: Rawla – volume: 19 start-page: 978 year: 2022 ident: 10.1016/j.wneu.2023.05.045_bib27 article-title: Spinal metastases and the evolving role of molecular targeted therapy, chemotherapy, and immunotherapy publication-title: Neurospine doi: 10.14245/ns.2244290.145 contributor: fullname: Fomchenko – year: 2008 ident: 10.1016/j.wneu.2023.05.045_bib13 – volume: 2011 start-page: 107969 year: 2011 ident: 10.1016/j.wneu.2023.05.045_bib16 article-title: Physiopathology of spine metastasis publication-title: Int J Surg Oncol contributor: fullname: Maccauro – volume: 366 start-page: 643 year: 2005 ident: 10.1016/j.wneu.2023.05.045_bib19 article-title: Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial publication-title: Lancet doi: 10.1016/S0140-6736(05)66954-1 contributor: fullname: Patchell – volume: 68 start-page: 674 year: 2011 ident: 10.1016/j.wneu.2023.05.045_bib11 article-title: Predictors of survival after surgical treatment of spinal metastasis publication-title: Neurosurgery doi: 10.1227/NEU.0b013e318207780c contributor: fullname: Arrigo – volume: 101-B start-page: 1379 year: 2019 ident: 10.1016/j.wneu.2023.05.045_bib12 article-title: Incidence and prognosis of patients with spinal metastasis as the initial manifestation of malignancy: analysis of 338 patients undergoing surgical treatment publication-title: Bone Joint J doi: 10.1302/0301-620X.101B11.BJJ-2018-1600.R2 contributor: fullname: Park – volume: 17 start-page: e183 year: 2018 ident: 10.1016/j.wneu.2023.05.045_bib5 article-title: Leptomeningeal carcinomatosis in colorectal cancer: the mayo clinic experience publication-title: Clin Colorectal Cancer doi: 10.1016/j.clcc.2017.11.003 contributor: fullname: Taylor – volume: 35 start-page: E187 year: 2022 ident: 10.1016/j.wneu.2023.05.045_bib6 article-title: Characteristics of patients undergoing surgical treatment for spinal metastases from colorectal cancer: a comparison with non-small cell lung cancer publication-title: Clin Spine Surg doi: 10.1097/BSD.0000000000001152 contributor: fullname: Park – volume: 10 start-page: 125 year: 1998 ident: 10.1016/j.wneu.2023.05.045_bib9 article-title: Cervical spine involvement in metastatic colorectal carcinoma publication-title: Clin Oncol doi: 10.1016/S0936-6555(05)80493-5 contributor: fullname: Geh – start-page: 17 year: 2006 ident: 10.1016/j.wneu.2023.05.045_bib18 article-title: The pathophysiology of spinal metastases contributor: fullname: Togawa – volume: 28 start-page: 1491 year: 2019 ident: 10.1016/j.wneu.2023.05.045_bib24 article-title: Development of a novel model for predicting survival of patients with spine metastasis from colorectal cancer publication-title: Eur Spine J doi: 10.1007/s00586-019-05879-5 contributor: fullname: Liu – volume: 22 start-page: 191 year: 2009 ident: 10.1016/j.wneu.2023.05.045_bib26 article-title: Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors publication-title: Clin Colon Rectal Surg doi: 10.1055/s-0029-1242458 contributor: fullname: Haggar – volume: 44 start-page: 175 year: 1999 ident: 10.1016/j.wneu.2023.05.045_bib10 article-title: Metastatic spinal cord compression in patients with colorectal cancer publication-title: J Neurooncol doi: 10.1023/A:1006312306713 contributor: fullname: Brown – volume: 12 start-page: 115 year: 2017 ident: 10.1016/j.wneu.2023.05.045_bib4 article-title: Spinal bone metastases in colorectal cancer: a retrospective analysis of stability, prognostic factors and survival after palliative radiotherapy publication-title: Radiat Oncol doi: 10.1186/s13014-017-0852-6 contributor: fullname: Bostel |
SSID | ssj0000314873 |
Score | 2.4100506 |
SecondaryResourceType | review_article |
Snippet | We present an institutional case series of patients treated for colorectal carcinoma (CRC) spinal metastases to investigate the outcomes between no treatment,... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | e246 |
SubjectTerms | Case series Colorectal cancer Colorectal Neoplasms - surgery Humans Middle Aged Neurosurgery Quality of Life Retrospective Studies Spinal metastasis Spinal Neoplasms - secondary Spinal Neoplasms - therapy Treatment Outcome |
Title | Spinal Metastases from Colorectal Cancer at Mass General Brigham: A Twenty-Year Case Series With Literature Review |
URI | https://dx.doi.org/10.1016/j.wneu.2023.05.045 https://www.ncbi.nlm.nih.gov/pubmed/37207725 https://www.proquest.com/docview/2816765151/abstract/ |
Volume | 176 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NT8IwFG8QLl6Mxi_8IDXxZgabbbfWGxIJfsAFiHhq9tFFTBwERogX_3bf2weJiXrwuHXduvfa1_fr-yLkMpAg9w3CEsZDi8cisHzJHCvE3G_KEbEIMVC4P3B7Y_4wEZMK6ZSxMOhWWcj-XKZn0rq40yqo2ZpPp62hI9ETTqASjQUkALfXYDvivEpq7fvH3mBz1IIZ2mVma8YuFvYpwmdyT691YlZNLCOe5fDEwKaft6jfVNBsK-rukp1Ch6TtfJh7pGKSfbIYzrHAFe2b1AeNb2mWFENHaAekG_4hNHWQwwvqp7QPKjMtMk7TWwTo_vsNbdPRGvagD-sFpj88vTQUD8_gTc_T9JU-bTIw09yicEDG3btRp2cVBRWsEJZyagnuhB5gCBbENgAl5nnSGNeVCkCeVIGwfWjwgHUsUF7gKB4xZUIAPMowgDWMHZJqMkvMMaGhjAC4eTxyI5-bWKqYqShkboCGNy7tOrkqaajned4MXTqUvWmkuEaKa1tooHidiJLM-hv3NQj2P_tdlDzRsCzQ1uEnZrZa6mvpuB6WeXfq5Chn1mYcWJgHQIU4-edXT8k2XuVugGekmi5W5hxUkzRokK3mp9MoJuAX7VLf7A |
link.rule.ids | 315,786,790,4521,24144,27957,27958,45620,45714 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwELaqdoAFgXiVp5HYUGiD7cRmKxFVSh9LWwGTlYcjikRatakq_j13TVIJCRhY4zix7-zzfb4XIdehBLlvEJYwHlk8EaEVSGZbEeZ-U7ZIRISBwv2B44_504t4qRCvjIVBt8pC9ucyfS2tiyeNgpqN2WTSGNoSPeEEKtFYQAJwe40L1-ZVUmt1uv5gc9WCGdrl2taMXSzsU4TP5J5eq9Qsb7GM-DqHJwY2_XxE_aaCro-i9i7ZKXRI2sqHuUcqJt0n8-EMC1zRvskC0PgWZkExdIR6IN1whtDkIYfnNMhoH1RmWmScpg8I0IOPe9qioxWcQZ_WKyx_eHthKF6ewZeeJ9kb7W0yMNPconBAxu3HkedbRUEFK4KtnFmC25ELGIKFSROAEnNdaYzjSAUgT6pQNANocIF1LFRuaCseM2UiADzKMIA1jB2SajpNzTGhkYwBuLk8duKAm0SqhKk4Yk6Ihjcum3VyU9JQz_K8Gbp0KHvXSHGNFNdNoYHidSJKMutv3Ncg2P_sd1XyRMO2QFtHkJrpcqHvpO24WObdrpOjnFmbcWBhHgAV4uSff70kW_6o39O9zqB7SraxJXcJPCPVbL4056CmZOFFsQy_AFV74d4 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Spinal+Metastases+from+Colorectal+Cancer+at+Mass+General+Brigham%3A+A+Twenty-Year+Case+Series+With+Literature+Review&rft.jtitle=World+neurosurgery&rft.au=Yearley%2C+Alexander+G.&rft.au=McNulty%2C+Jack+J.&rft.au=Chalif%2C+Eric+J.&rft.au=Chalif%2C+Joshua+I.&rft.date=2023-08-01&rft.pub=Elsevier+Inc&rft.issn=1878-8750&rft.eissn=1878-8769&rft.volume=176&rft.spage=e246&rft.epage=e253&rft_id=info:doi/10.1016%2Fj.wneu.2023.05.045&rft.externalDocID=S1878875023006800 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1878-8750&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1878-8750&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1878-8750&client=summon |