Tonic type 2 immunity is a critical tissue checkpoint controlling autoimmunity in the skin

• Published in: Cell reports (Cambridge) Vol. 43; no. 7; p. 114364
• Main Authors: Lee, Jeong-Eun, Kim, Mina, Ochiai, Sotaro, Kim, Sung-Hee, Yeo, Hyeonuk, Bok, Jahyun, Kim, Jiyeon, Park, Miso, Kim, Daehong, Lamiable, Olivier, Lee, Myunggyo, Kim, Min-Ju, Kim, Hye Young, Ronchese, Franca, Kwon, Sung Won, Lee, Haeseung, Kim, Tae-Gyun, Chung, Yeonseok
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.07.2024; Elsevier
• Subjects: CP: Immunology; fatty acid metabolism; LXR; PPARγ; psoriasis; tonic type 2 immunity; CP: Immunology; tonic type 2 immunity; fatty acid metabolism; psoriasis; PPARγ; LXR

Immunoregulatory mechanisms established in the lymphoid organs are vital for preventing autoimmunity. However, the presence of similar mechanisms in non-lymphoid tissues remains unclear. Through transcriptomic and lipidomic analyses, we find a negative association between psoriasis and fatty acid me...