Tonic type 2 immunity is a critical tissue checkpoint controlling autoimmunity in the skin

Immunoregulatory mechanisms established in the lymphoid organs are vital for preventing autoimmunity. However, the presence of similar mechanisms in non-lymphoid tissues remains unclear. Through transcriptomic and lipidomic analyses, we find a negative association between psoriasis and fatty acid me...

Full description

Saved in:
Bibliographic Details
Published inCell reports (Cambridge) Vol. 43; no. 7; p. 114364
Main Authors Lee, Jeong-Eun, Kim, Mina, Ochiai, Sotaro, Kim, Sung-Hee, Yeo, Hyeonuk, Bok, Jahyun, Kim, Jiyeon, Park, Miso, Kim, Daehong, Lamiable, Olivier, Lee, Myunggyo, Kim, Min-Ju, Kim, Hye Young, Ronchese, Franca, Kwon, Sung Won, Lee, Haeseung, Kim, Tae-Gyun, Chung, Yeonseok
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 23.07.2024
Elsevier
Subjects
CP: Immunology
fatty acid metabolism
LXR
PPARγ
psoriasis
tonic type 2 immunity
CP: Immunology
tonic type 2 immunity
fatty acid metabolism
psoriasis
PPARγ
LXR
Online AccessGet full text

Cover

Abstract Immunoregulatory mechanisms established in the lymphoid organs are vital for preventing autoimmunity. However, the presence of similar mechanisms in non-lymphoid tissues remains unclear. Through transcriptomic and lipidomic analyses, we find a negative association between psoriasis and fatty acid metabolism, as well as Th2 signature. Homeostatic expression of liver X receptor (LXR) and peroxisome proliferator-activated receptor gamma (PPARγ) is essential for maintaining fatty acid metabolism and for conferring resistance to psoriasis in mice. Perturbation of signal transducer and activator of transcription 6 (STAT6) diminishes the homeostatic levels of LXR and PPARγ. Furthermore, mice lacking STAT6, interleukin 4 receptor alpha (IL-4Rα), or IL-13, but not IL-4, exhibit increased susceptibility to psoriasis. Under steady state, innate lymphoid cells (ILCs) are the primary producers of IL-13. In human skin, inhibiting tonic type 2 immunity exacerbates psoriasis-like inflammation and IL-17A, while activating LXR or PPARγ inhibits them. Hence, we propose that tonic type 2 immunity, driven by IL-13-producing ILCs, represents a crucial tissue checkpoint that represses autoimmunity and maintains lipid homeostasis in the skin. [Display omitted] •Psoriasis induces a downregulation of fatty acid metabolism and Th2 signature genes•LXR and PPARγ are required for the resistance to psoriasis and lipid homeostasis•IL-13-producing ILCs are responsible for tonic type 2 immunity in normal skin•Inhibiting tonic type 2 immunity worsens psoriatic inflammation in mice and humans Lee et al. show that fatty acid dysregulation occurs in psoriatic skin. Lack of LXR or PPARγ exacerbates psoriasis progression, and LXR and PPARγ homeostasis is maintained by tonic type 2 immunity. IL-13-producing ILCs are in charge of tonic type 2 immunity and contribute to the resistance to autoimmunity.
AbstractList Immunoregulatory mechanisms established in the lymphoid organs are vital for preventing autoimmunity. However, the presence of similar mechanisms in non-lymphoid tissues remains unclear. Through transcriptomic and lipidomic analyses, we find a negative association between psoriasis and fatty acid metabolism, as well as Th2 signature. Homeostatic expression of liver X receptor (LXR) and peroxisome proliferator-activated receptor gamma (PPARγ) is essential for maintaining fatty acid metabolism and for conferring resistance to psoriasis in mice. Perturbation of signal transducer and activator of transcription 6 (STAT6) diminishes the homeostatic levels of LXR and PPARγ. Furthermore, mice lacking STAT6, interleukin 4 receptor alpha (IL-4Rα), or IL-13, but not IL-4, exhibit increased susceptibility to psoriasis. Under steady state, innate lymphoid cells (ILCs) are the primary producers of IL-13. In human skin, inhibiting tonic type 2 immunity exacerbates psoriasis-like inflammation and IL-17A, while activating LXR or PPARγ inhibits them. Hence, we propose that tonic type 2 immunity, driven by IL-13-producing ILCs, represents a crucial tissue checkpoint that represses autoimmunity and maintains lipid homeostasis in the skin.
Immunoregulatory mechanisms established in the lymphoid organs are vital for preventing autoimmunity. However, the presence of similar mechanisms in non-lymphoid tissues remains unclear. Through transcriptomic and lipidomic analyses, we find a negative association between psoriasis and fatty acid metabolism, as well as Th2 signature. Homeostatic expression of liver X receptor (LXR) and peroxisome proliferator-activated receptor gamma (PPARγ) is essential for maintaining fatty acid metabolism and for conferring resistance to psoriasis in mice. Perturbation of signal transducer and activator of transcription 6 (STAT6) diminishes the homeostatic levels of LXR and PPARγ. Furthermore, mice lacking STAT6, interleukin 4 receptor alpha (IL-4Rα), or IL-13, but not IL-4, exhibit increased susceptibility to psoriasis. Under steady state, innate lymphoid cells (ILCs) are the primary producers of IL-13. In human skin, inhibiting tonic type 2 immunity exacerbates psoriasis-like inflammation and IL-17A, while activating LXR or PPARγ inhibits them. Hence, we propose that tonic type 2 immunity, driven by IL-13-producing ILCs, represents a crucial tissue checkpoint that represses autoimmunity and maintains lipid homeostasis in the skin. [Display omitted] •Psoriasis induces a downregulation of fatty acid metabolism and Th2 signature genes•LXR and PPARγ are required for the resistance to psoriasis and lipid homeostasis•IL-13-producing ILCs are responsible for tonic type 2 immunity in normal skin•Inhibiting tonic type 2 immunity worsens psoriatic inflammation in mice and humans Lee et al. show that fatty acid dysregulation occurs in psoriatic skin. Lack of LXR or PPARγ exacerbates psoriasis progression, and LXR and PPARγ homeostasis is maintained by tonic type 2 immunity. IL-13-producing ILCs are in charge of tonic type 2 immunity and contribute to the resistance to autoimmunity.
Immunoregulatory mechanisms established in the lymphoid organs are vital for preventing autoimmunity. However, the presence of similar mechanisms in non-lymphoid tissues remains unclear. Through transcriptomic and lipidomic analyses, we find a negative association between psoriasis and fatty acid metabolism, as well as Th2 signature. Homeostatic expression of liver X receptor (LXR) and peroxisome proliferator-activated receptor gamma (PPARγ) is essential for maintaining fatty acid metabolism and for conferring resistance to psoriasis in mice. Perturbation of signal transducer and activator of transcription 6 (STAT6) diminishes the homeostatic levels of LXR and PPARγ. Furthermore, mice lacking STAT6, interleukin 4 receptor alpha (IL-4Rα), or IL-13, but not IL-4, exhibit increased susceptibility to psoriasis. Under steady state, innate lymphoid cells (ILCs) are the primary producers of IL-13. In human skin, inhibiting tonic type 2 immunity exacerbates psoriasis-like inflammation and IL-17A, while activating LXR or PPARγ inhibits them. Hence, we propose that tonic type 2 immunity, driven by IL-13-producing ILCs, represents a crucial tissue checkpoint that represses autoimmunity and maintains lipid homeostasis in the skin.Immunoregulatory mechanisms established in the lymphoid organs are vital for preventing autoimmunity. However, the presence of similar mechanisms in non-lymphoid tissues remains unclear. Through transcriptomic and lipidomic analyses, we find a negative association between psoriasis and fatty acid metabolism, as well as Th2 signature. Homeostatic expression of liver X receptor (LXR) and peroxisome proliferator-activated receptor gamma (PPARγ) is essential for maintaining fatty acid metabolism and for conferring resistance to psoriasis in mice. Perturbation of signal transducer and activator of transcription 6 (STAT6) diminishes the homeostatic levels of LXR and PPARγ. Furthermore, mice lacking STAT6, interleukin 4 receptor alpha (IL-4Rα), or IL-13, but not IL-4, exhibit increased susceptibility to psoriasis. Under steady state, innate lymphoid cells (ILCs) are the primary producers of IL-13. In human skin, inhibiting tonic type 2 immunity exacerbates psoriasis-like inflammation and IL-17A, while activating LXR or PPARγ inhibits them. Hence, we propose that tonic type 2 immunity, driven by IL-13-producing ILCs, represents a crucial tissue checkpoint that represses autoimmunity and maintains lipid homeostasis in the skin.
ArticleNumber 114364
Author Bok, Jahyun
Kim, Tae-Gyun
Lee, Haeseung
Kim, Sung-Hee
Park, Miso
Kim, Jiyeon
Chung, Yeonseok
Lee, Myunggyo
Yeo, Hyeonuk
Kim, Daehong
Kim, Min-Ju
Kwon, Sung Won
Ronchese, Franca
Kim, Mina
Kim, Hye Young
Lee, Jeong-Eun
Lamiable, Olivier
Ochiai, Sotaro
Author_xml – sequence: 1
  givenname: Jeong-Eun
  surname: Lee
  fullname: Lee, Jeong-Eun
  organization: Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Republic of Korea
– sequence: 2
  givenname: Mina
  surname: Kim
  fullname: Kim, Mina
  organization: Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Republic of Korea
– sequence: 3
  givenname: Sotaro
  surname: Ochiai
  fullname: Ochiai, Sotaro
  organization: Malaghan Institute of Medical Research, Wellington, New Zealand
– sequence: 4
  givenname: Sung-Hee
  surname: Kim
  fullname: Kim, Sung-Hee
  organization: Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
– sequence: 5
  givenname: Hyeonuk
  surname: Yeo
  fullname: Yeo, Hyeonuk
  organization: Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Republic of Korea
– sequence: 6
  givenname: Jahyun
  surname: Bok
  fullname: Bok, Jahyun
  organization: Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Republic of Korea
– sequence: 7
  givenname: Jiyeon
  surname: Kim
  fullname: Kim, Jiyeon
  organization: Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Republic of Korea
– sequence: 8
  givenname: Miso
  surname: Park
  fullname: Park, Miso
  organization: Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Republic of Korea
– sequence: 9
  givenname: Daehong
  surname: Kim
  fullname: Kim, Daehong
  organization: Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Republic of Korea
– sequence: 10
  givenname: Olivier
  surname: Lamiable
  fullname: Lamiable, Olivier
  organization: Malaghan Institute of Medical Research, Wellington, New Zealand
– sequence: 11
  givenname: Myunggyo
  surname: Lee
  fullname: Lee, Myunggyo
  organization: College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea
– sequence: 12
  givenname: Min-Ju
  surname: Kim
  fullname: Kim, Min-Ju
  organization: College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea
– sequence: 13
  givenname: Hye Young
  surname: Kim
  fullname: Kim, Hye Young
  organization: College of Medicine, Seoul National University, Seoul, Republic of Korea
– sequence: 14
  givenname: Franca
  surname: Ronchese
  fullname: Ronchese, Franca
  email: fronchese@malaghan.org.nz
  organization: Malaghan Institute of Medical Research, Wellington, New Zealand
– sequence: 15
  givenname: Sung Won
  surname: Kwon
  fullname: Kwon, Sung Won
  email: swkwon@snu.ac.kr
  organization: Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Republic of Korea
– sequence: 16
  givenname: Haeseung
  surname: Lee
  fullname: Lee, Haeseung
  email: haeseung@pusan.ac.kr
  organization: College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea
– sequence: 17
  givenname: Tae-Gyun
  surname: Kim
  fullname: Kim, Tae-Gyun
  email: tgmed83@yuhs.ac
  organization: Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
– sequence: 18
  givenname: Yeonseok
  orcidid: 0000-0001-5780-4841
  surname: Chung
  fullname: Chung, Yeonseok
  email: yeonseok@snu.ac.kr
  organization: Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, Republic of Korea
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38900635$$D View this record in MEDLINE/PubMed
BookMark eNp9UUtvFSEUJqbG1tp_YAxLN_fKe4aNiWl8NGnipm7cEAbOtNzOwAiMyf33UqdWV7I5cPI9OOd7iU5iioDQa0r2lFD17rB3MGVY9owwsadUcCWeoTPGKN1RJrqTf-6n6KKUA2lHEUq1eIFOea_bi8sz9P0mxeBwPS6AGQ7zvMZQjzgUbLHLoQZnJ1xDKStgdwfufkkhVuxSrDlNU4i32K41_SVGXO8Al_sQX6Hno50KXDzWc_Tt08ebyy-766-fry4_XO8cJ13dSUq9kkwRDopSMmjZd0z6fnRC93zooaej1KPiilmldMcYIbqToJ2HUYqBn6OrTdcnezBLDrPNR5NsML8bKd8am9sgExigY8e5sIyJQQivhs71XgwjVYMXXoqm9XbTWnL6sUKpZg6lrXqyEdJaTPsx6bmWSjeo2KAup1IyjE_WlJiHkMzBbCGZh5DMFlKjvXl0WIcZ_BPpTyQN8H4DQNvZzwDZFBcgOvAhg6ttqPB_h18UOqTz
Cites_doi 10.1016/j.immuni.2022.08.001
10.1016/j.jaci.2022.12.823
10.1016/j.immuni.2014.12.007
10.1093/bioinformatics/bts635
10.3390/ijms21051690
10.1186/1471-2105-12-323
10.1038/nmeth.2551
10.3389/fimmu.2017.01676
10.1038/nmeth.3393
10.1021/ac400515s
10.1038/s41586-021-03188-w
10.1093/nar/gkaa1057
10.1093/nar/gkad841
10.1016/j.jaad.2019.06.026
10.1111/exd.13467
10.1242/dmm.009092
10.1080/09546634.2019.1610552
10.1126/sciimmunol.aal5196
10.1016/j.jaci.2012.01.052
10.1038/JID.2015.406
10.1146/annurev-neuro-111020-105359
10.1073/pnas.2100749118
10.1084/jem.20130071
10.1038/s41577-018-0084-5
10.1038/nrmicro.2017.157
10.1038/nature07202
10.4049/jimmunol.0802999
10.1038/s41590-021-01067-0
10.1038/ni.2584
10.1084/jem.20162069
10.1128/IAI.00822-15
10.1194/jlr.R700015-JLR200
10.1242/dev.02721
10.4049/jimmunol.1701186
10.1126/science.aba6500
10.4049/jimmunol.1700596
10.1084/jem.20050500
10.1001/jama.2020.4006
10.1136/ebmed-2011-100388
10.1016/j.pharmthera.2011.06.008
10.1038/s41590-018-0201-4
10.4049/jimmunol.176.7.4385
10.1016/j.bbalip.2013.11.006
10.1016/j.it.2012.11.005
10.1101/gad.1115203
10.1194/jlr.D700041-JLR200
10.1021/acs.analchem.7b03404
10.1007/s40257-021-00646-z
10.1038/nm804
10.1038/s41385-020-0265-y
10.1001/archderm.140.12.1490
10.3389/fimmu.2020.576929
10.1093/nar/gkab382
10.1038/nmeth.2089
10.1038/s41598-017-17204-5
10.1083/jcb.200605057
10.1016/j.jaad.2021.01.012
10.1016/j.immuni.2020.03.003
10.1016/j.clindermatol.2008.01.015
ContentType Journal Article
Copyright 2024 The Author(s)
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2024 The Author(s)
– notice: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
DBID 6I.
AAFTH
NPM
AAYXX
CITATION
7X8
DOA
DOI 10.1016/j.celrep.2024.114364
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
PubMed
CrossRef
MEDLINE - Academic
Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList

PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2211-1247
ExternalDocumentID oai_doaj_org_article_e1f7334a224b44d6b7c8d4bf16bd4d54
10_1016_j_celrep_2024_114364
38900635
S2211124724006922
Genre Journal Article
GroupedDBID 0R~
0SF
4.4
457
53G
5VS
6I.
AACTN
AAEDT
AAEDW
AAFTH
AAIKJ
AAKRW
AALRI
AAMRU
AAXUO
ABMAC
ACGFO
ACGFS
ADBBV
ADEZE
ADVLN
AENEX
AEXQZ
AFTJW
AGHFR
AITUG
AKRWK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
BAWUL
BCNDV
DIK
EBS
EJD
FCP
FDB
FRP
GROUPED_DOAJ
GX1
IXB
KQ8
M41
M48
NCXOZ
O-L
O9-
OK1
RCE
ROL
SSZ
NPM
AAYXX
CITATION
HZ~
IPNFZ
RIG
7X8
ID FETCH-LOGICAL-c307t-511d652603e6110b958725d8fc4983b8e81f59f6362a66972200975e9cdef54b3
IEDL.DBID DOA
ISSN 2211-1247
IngestDate Tue Oct 22 15:08:56 EDT 2024
Sat Oct 26 04:33:06 EDT 2024
Wed Nov 27 13:02:25 EST 2024
Sat Nov 02 12:29:22 EDT 2024
Sat Oct 26 15:42:11 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Keywords CP: Immunology
tonic type 2 immunity
fatty acid metabolism
psoriasis
PPARγ
LXR
Language English
License This is an open access article under the CC BY-NC license.
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c307t-511d652603e6110b958725d8fc4983b8e81f59f6362a66972200975e9cdef54b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0001-5780-4841
OpenAccessLink https://doaj.org/article/e1f7334a224b44d6b7c8d4bf16bd4d54
PMID 38900635
PQID 3070839569
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_e1f7334a224b44d6b7c8d4bf16bd4d54
proquest_miscellaneous_3070839569
crossref_primary_10_1016_j_celrep_2024_114364
pubmed_primary_38900635
elsevier_sciencedirect_doi_10_1016_j_celrep_2024_114364
PublicationCentury 2000
PublicationDate 2024-07-23
PublicationDateYYYYMMDD 2024-07-23
PublicationDate_xml – month: 07
  year: 2024
  text: 2024-07-23
  day: 23
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Cell reports (Cambridge)
PublicationTitleAlternate Cell Rep
PublicationYear 2024
Publisher Elsevier Inc
Elsevier
Publisher_xml – name: Elsevier Inc
– name: Elsevier
References Nobs, Natali, Pohlmeier, Okreglicka, Schneider, Kurrer, Sallusto, Kopf (bib46) 2017; 214
Chen, Tibbitt, Feng, Stark, Rohrbeck, Rausch, Sedimbi, Karlsson, Lambrecht, Karlsson Hedestam (bib47) 2017; 2
Johnson-Huang, Lowes, Krueger (bib12) 2012; 5
Nguyen, Hanzelmann, Härtner, Peschel, Götz (bib15) 2016; 84
Bensinger, Tontonoz (bib18) 2008; 454
Schenkel, Masopust (bib4) 2014; 41
Jo, Finstad, Georgakopoulos, Piguet, Yeung, Drucker (bib29) 2021; 84
Waldman, DeWane, Sloan, Grant-Kels (bib28) 2020; 82
Dobin, Davis, Schlesinger, Drenkow, Zaleski, Jha, Batut, Chaisson, Gingeras (bib53) 2013; 29
Pang, Chong, Zhou, de Lima Morais, Chang, Barrette, Gauthier, Jacques, Li, Xia (bib55) 2021; 49
Bielecki, Riesenfeld, Hütter, Torlai Triglia, Kowalczyk, Ricardo-Gonzalez, Lian, Amezcua Vesely, Kroehling, Xu (bib36) 2021; 592
Müller-Dott, Tsirvouli, Vazquez, Ramirez Flores, Badia-i-Mompel, Fallegger, Türei, Lægreid, Saez-Rodriguez (bib21) 2023; 51
de Guzman Strong, Wertz, Wang, Yang, Meltzer, Andl, Millar, Ho, Pai, Segre (bib22) 2006; 175
Krueger, Brunner (bib8) 2018; 27
Clayton, Vallejo, Davies, Sirvent, Polak (bib3) 2017; 8
Cajka, Smilowitz, Fiehn (bib59) 2017; 89
Mayer, Hilligan, Chandler, Eccles, Old, Domingues, Yang, Webb, Munoz-Erazo, Hyde (bib42) 2021; 22
Kurek, Garinis, van Doorninck, van der Wees, Grosveld (bib50) 2007; 134
Byrd, Belkaid, Segre (bib16) 2018; 16
Ricardo-Gonzalez, Kotas, O’Leary, Singh, Damsky, Liao, Arouge, Tenvooren, Marquez, Schroeder (bib5) 2022; 55
Nestle, Conrad, Tun-Kyi, Homey, Gombert, Boyman, Burg, Liu, Gilliet (bib7) 2005; 202
Fluhr, Cavallotti, Berardesca (bib11) 2008; 26
Lowes, Russell, Martin, Towne, Krueger (bib1) 2013; 34
Smith, Thiboutot (bib17) 2008; 49
Kabashima, Honda, Ginhoux, Egawa (bib13) 2019; 19
Kind, Liu, Lee, DeFelice, Meissen, Fiehn (bib56) 2013; 10
Chang, Wang, Song, Zhang, Zhang (bib32) 2020; 31
Koelink, Overbeek, Braber, de Kruijf, Folkerts, Smit, Kraneveld (bib2) 2012; 133
Ghoreschi, Thomas, Breit, Dugas, Mailhammer, van Eden, van der Zee, Biedermann, Prinz, Mack (bib27) 2003; 9
Chen, Shu, Fan (bib40) 2020; 11
Ricardo-Gonzalez, Van Dyken, Schneider, Lee, Nussbaum, Liang, Vaka, Eckalbar, Molofsky, Erle (bib38) 2018; 19
Rak, Osborne, Siracusa, Kim, Wang, Bayat, Artis, Volk (bib34) 2016; 136
Reynolds, Vegh, Fletcher, Poyner, Stephenson, Goh, Botting, Huang, Olabi, Dubois (bib19) 2021; 371
Li, Dewey (bib54) 2011; 12
Crapster-Pregont, Yeo, Sanchez, Kuperman (bib43) 2012; 129
Muzumdar, Skudalski, Sharp, Waldman (bib30) 2022; 23
Bankhead, Loughrey, Fernández, Dombrowski, McArt, Dunne, McQuaid, Gray, Murray, Coleman (bib60) 2017; 7
Kamata, Tada (bib10) 2020; 21
Seo, Giles, Kronenberg (bib35) 2020; 13
Tsugawa, Cajka, Kind, Ma, Higgins, Ikeda, Kanazawa, VanderGheynst, Fiehn, Arita (bib57) 2015; 12
Kim, Oh, Roh, Park, Chung, Lee, Lee, Kim, Lee, Lee (bib26) 2023; 151
Matyash, Liebisch, Kurzchalia, Shevchenko, Schwudke (bib51) 2008; 49
Gilliet, Conrad, Geiges, Cozzio, Thürlimann, Burg, Nestle, Dummer (bib24) 2004; 140
Karagiannis, Masouleh, Wunderling, Surendar, Schmitt, Kazakov, Michla, Hölzel, Thiele, Wilhelm (bib45) 2020; 52
Soare, Weber, Maul, Rauber, Gheorghiu, Luber, Houssni, Kleyer, von Pickardt, Gado (bib37) 2018; 200
van Smeden, Janssens, Gooris, Bouwstra (bib14) 2014; 1841
Paintlia, Paintlia, Singh, Singh (bib48) 2006; 176
Kaufman, Zhou, Pasolli, Rendl, Bolotin, Lim, Dai, Alegre, Fuchs (bib49) 2003; 17
Klein Wolterink, Wu, Chiu, Veiga-Fernandes (bib39) 2022; 45
Barik, Cattin-Roy, Miller, Ukah, Zaghouani (bib41) 2018; 201
Schneider, Rasband, Eliceiri (bib52) 2012; 9
Armstrong, Read (bib6) 2020; 323
Patel, Mark, Machler, Levine (bib25) 2011; 164
Tsugawa, Arita, Kanazawa, Ogiwara, Bamba, Fukusaki (bib58) 2013; 85
Zhang, Chinnappan, Prestwood, Edwards, Artami, Thompson, Eckert, Vale, Zouboulis, McDonald (bib44) 2021; 118
Turner, Morrison, Wilhelm, Wilson, Ahlfors, Renauld, Panzer, Helmby, Stockinger (bib33) 2013; 210
van der Fits, Mourits, Voerman, Kant, Boon, Laman, Cornelissen, Mus, Florencia, Prens (bib9) 2009; 182
Malhotra, Shafiq, Rajagopalan, Dogra, Malhotra (bib31) 2012; 17
Kolmykov, Yevshin, Kulyashov, Sharipov, Kondrakhin, Makeev, Kulakovskiy, Kel, Kolpakov (bib20) 2021; 49
Roediger, Kyle, Yip, Sumaria, Guy, Kim, Mitchell, Tay, Jain, Forbes-Blom (bib23) 2013; 14
Chang (10.1016/j.celrep.2024.114364_bib32) 2020; 31
Armstrong (10.1016/j.celrep.2024.114364_bib6) 2020; 323
Ricardo-Gonzalez (10.1016/j.celrep.2024.114364_bib38) 2018; 19
Lowes (10.1016/j.celrep.2024.114364_bib1) 2013; 34
Kabashima (10.1016/j.celrep.2024.114364_bib13) 2019; 19
Muzumdar (10.1016/j.celrep.2024.114364_bib30) 2022; 23
Bensinger (10.1016/j.celrep.2024.114364_bib18) 2008; 454
Dobin (10.1016/j.celrep.2024.114364_bib53) 2013; 29
Smith (10.1016/j.celrep.2024.114364_bib17) 2008; 49
Karagiannis (10.1016/j.celrep.2024.114364_bib45) 2020; 52
Patel (10.1016/j.celrep.2024.114364_bib25) 2011; 164
Seo (10.1016/j.celrep.2024.114364_bib35) 2020; 13
Roediger (10.1016/j.celrep.2024.114364_bib23) 2013; 14
Kind (10.1016/j.celrep.2024.114364_bib56) 2013; 10
Nguyen (10.1016/j.celrep.2024.114364_bib15) 2016; 84
Kolmykov (10.1016/j.celrep.2024.114364_bib20) 2021; 49
Nestle (10.1016/j.celrep.2024.114364_bib7) 2005; 202
de Guzman Strong (10.1016/j.celrep.2024.114364_bib22) 2006; 175
Kim (10.1016/j.celrep.2024.114364_bib26) 2023; 151
Paintlia (10.1016/j.celrep.2024.114364_bib48) 2006; 176
van Smeden (10.1016/j.celrep.2024.114364_bib14) 2014; 1841
Chen (10.1016/j.celrep.2024.114364_bib40) 2020; 11
Mayer (10.1016/j.celrep.2024.114364_bib42) 2021; 22
Turner (10.1016/j.celrep.2024.114364_bib33) 2013; 210
Johnson-Huang (10.1016/j.celrep.2024.114364_bib12) 2012; 5
Rak (10.1016/j.celrep.2024.114364_bib34) 2016; 136
Pang (10.1016/j.celrep.2024.114364_bib55) 2021; 49
Koelink (10.1016/j.celrep.2024.114364_bib2) 2012; 133
Ricardo-Gonzalez (10.1016/j.celrep.2024.114364_bib5) 2022; 55
Schenkel (10.1016/j.celrep.2024.114364_bib4) 2014; 41
Jo (10.1016/j.celrep.2024.114364_bib29) 2021; 84
Matyash (10.1016/j.celrep.2024.114364_bib51) 2008; 49
Ghoreschi (10.1016/j.celrep.2024.114364_bib27) 2003; 9
Müller-Dott (10.1016/j.celrep.2024.114364_bib21) 2023; 51
Klein Wolterink (10.1016/j.celrep.2024.114364_bib39) 2022; 45
Tsugawa (10.1016/j.celrep.2024.114364_bib57) 2015; 12
Barik (10.1016/j.celrep.2024.114364_bib41) 2018; 201
Li (10.1016/j.celrep.2024.114364_bib54) 2011; 12
Waldman (10.1016/j.celrep.2024.114364_bib28) 2020; 82
Crapster-Pregont (10.1016/j.celrep.2024.114364_bib43) 2012; 129
Fluhr (10.1016/j.celrep.2024.114364_bib11) 2008; 26
Reynolds (10.1016/j.celrep.2024.114364_bib19) 2021; 371
Bankhead (10.1016/j.celrep.2024.114364_bib60) 2017; 7
Krueger (10.1016/j.celrep.2024.114364_bib8) 2018; 27
Zhang (10.1016/j.celrep.2024.114364_bib44) 2021; 118
Cajka (10.1016/j.celrep.2024.114364_bib59) 2017; 89
Clayton (10.1016/j.celrep.2024.114364_bib3) 2017; 8
Byrd (10.1016/j.celrep.2024.114364_bib16) 2018; 16
van der Fits (10.1016/j.celrep.2024.114364_bib9) 2009; 182
Malhotra (10.1016/j.celrep.2024.114364_bib31) 2012; 17
Kaufman (10.1016/j.celrep.2024.114364_bib49) 2003; 17
Bielecki (10.1016/j.celrep.2024.114364_bib36) 2021; 592
Tsugawa (10.1016/j.celrep.2024.114364_bib58) 2013; 85
Nobs (10.1016/j.celrep.2024.114364_bib46) 2017; 214
Gilliet (10.1016/j.celrep.2024.114364_bib24) 2004; 140
Kamata (10.1016/j.celrep.2024.114364_bib10) 2020; 21
Chen (10.1016/j.celrep.2024.114364_bib47) 2017; 2
Schneider (10.1016/j.celrep.2024.114364_bib52) 2012; 9
Soare (10.1016/j.celrep.2024.114364_bib37) 2018; 200
Kurek (10.1016/j.celrep.2024.114364_bib50) 2007; 134
References_xml – volume: 200
  start-page: 1249
  year: 2018
  end-page: 1254
  ident: bib37
  article-title: Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis
  publication-title: J. Immunol.
  contributor:
    fullname: Gado
– volume: 13
  start-page: 399
  year: 2020
  end-page: 412
  ident: bib35
  article-title: The role of innate lymphoid cells in response to microbes at mucosal surfaces
  publication-title: Mucosal Immunol.
  contributor:
    fullname: Kronenberg
– volume: 19
  start-page: 19
  year: 2019
  end-page: 30
  ident: bib13
  article-title: The immunological anatomy of the skin
  publication-title: Nat. Rev. Immunol.
  contributor:
    fullname: Egawa
– volume: 55
  start-page: 1891
  year: 2022
  end-page: 1908.e12
  ident: bib5
  article-title: Innate type 2 immunity controls hair follicle commensalism by Demodex mites
  publication-title: Immunity
  contributor:
    fullname: Schroeder
– volume: 11
  year: 2020
  ident: bib40
  article-title: Neural Regulation of Interactions Between Group 2 Innate Lymphoid Cells and Pulmonary Immune Cells
  publication-title: Front. Immunol.
  contributor:
    fullname: Fan
– volume: 22
  start-page: 1538
  year: 2021
  end-page: 1550
  ident: bib42
  article-title: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization
  publication-title: Nat. Immunol.
  contributor:
    fullname: Hyde
– volume: 26
  start-page: 380
  year: 2008
  end-page: 386
  ident: bib11
  article-title: Emollients, moisturizers, and keratolytic agents in psoriasis
  publication-title: Clin. Dermatol.
  contributor:
    fullname: Berardesca
– volume: 202
  start-page: 135
  year: 2005
  end-page: 143
  ident: bib7
  article-title: Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
  publication-title: J. Exp. Med.
  contributor:
    fullname: Gilliet
– volume: 118
  year: 2021
  ident: bib44
  article-title: Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: McDonald
– volume: 454
  start-page: 470
  year: 2008
  end-page: 477
  ident: bib18
  article-title: Integration of metabolism and inflammation by lipid-activated nuclear receptors
  publication-title: Nature
  contributor:
    fullname: Tontonoz
– volume: 29
  start-page: 15
  year: 2013
  end-page: 21
  ident: bib53
  article-title: STAR: ultrafast universal RNA-seq aligner
  publication-title: Bioinformatics
  contributor:
    fullname: Gingeras
– volume: 84
  start-page: 1339
  year: 2021
  end-page: 1347
  ident: bib29
  article-title: Facial and neck erythema associated with dupilumab treatment: A systematic review
  publication-title: J. Am. Acad. Dermatol.
  contributor:
    fullname: Drucker
– volume: 176
  start-page: 4385
  year: 2006
  end-page: 4398
  ident: bib48
  article-title: IL-4-induced peroxisome proliferator-activated receptor gamma activation inhibits NF-kappaB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication for CNS-demyelinating diseases
  publication-title: J. Immunol.
  contributor:
    fullname: Singh
– volume: 592
  start-page: 128
  year: 2021
  end-page: 132
  ident: bib36
  article-title: Skin-resident innate lymphoid cells converge on a pathogenic effector state
  publication-title: Nature
  contributor:
    fullname: Xu
– volume: 8
  year: 2017
  ident: bib3
  article-title: Langerhans Cells—Programmed by the Epidermis
  publication-title: Front. Immunol.
  contributor:
    fullname: Polak
– volume: 210
  start-page: 2951
  year: 2013
  end-page: 2965
  ident: bib33
  article-title: IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
  publication-title: J. Exp. Med.
  contributor:
    fullname: Stockinger
– volume: 9
  start-page: 671
  year: 2012
  end-page: 675
  ident: bib52
  article-title: NIH Image to ImageJ: 25 years of image analysis
  publication-title: Nat. Methods
  contributor:
    fullname: Eliceiri
– volume: 12
  start-page: 323
  year: 2011
  ident: bib54
  article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
  publication-title: BMC Bioinf.
  contributor:
    fullname: Dewey
– volume: 10
  start-page: 755
  year: 2013
  end-page: 758
  ident: bib56
  article-title: LipidBlast in silico tandem mass spectrometry database for lipid identification
  publication-title: Nat. Methods
  contributor:
    fullname: Fiehn
– volume: 323
  start-page: 1945
  year: 2020
  end-page: 1960
  ident: bib6
  article-title: Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review
  publication-title: JAMA
  contributor:
    fullname: Read
– volume: 82
  start-page: 230
  year: 2020
  end-page: 232
  ident: bib28
  article-title: Characterizing dupilumab facial redness: A multi-institution retrospective medical record review
  publication-title: J. Am. Acad. Dermatol.
  contributor:
    fullname: Grant-Kels
– volume: 31
  start-page: 680
  year: 2020
  end-page: 686
  ident: bib32
  article-title: Efficacy and safety of pioglitazone for treatment of plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials
  publication-title: J. Dermatolog. Treat.
  contributor:
    fullname: Zhang
– volume: 2
  year: 2017
  ident: bib47
  article-title: PPAR-γ promotes type 2 immune responses in allergy and nematode infection
  publication-title: Sci. Immunol.
  contributor:
    fullname: Karlsson Hedestam
– volume: 12
  start-page: 523
  year: 2015
  end-page: 526
  ident: bib57
  article-title: MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis
  publication-title: Nat. Methods
  contributor:
    fullname: Arita
– volume: 85
  start-page: 5191
  year: 2013
  end-page: 5199
  ident: bib58
  article-title: MRMPROBS: a data assessment and metabolite identification tool for large-scale multiple reaction monitoring based widely targeted metabolomics
  publication-title: Anal. Chem.
  contributor:
    fullname: Fukusaki
– volume: 134
  start-page: 261
  year: 2007
  end-page: 272
  ident: bib50
  article-title: Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles
  publication-title: Development
  contributor:
    fullname: Grosveld
– volume: 17
  start-page: 2108
  year: 2003
  end-page: 2122
  ident: bib49
  article-title: GATA-3: an unexpected regulator of cell lineage determination in skin
  publication-title: Genes Dev.
  contributor:
    fullname: Fuchs
– volume: 214
  start-page: 3015
  year: 2017
  end-page: 3035
  ident: bib46
  article-title: PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation
  publication-title: J. Exp. Med.
  contributor:
    fullname: Kopf
– volume: 49
  start-page: W388
  year: 2021
  end-page: W396
  ident: bib55
  article-title: MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Xia
– volume: 140
  start-page: 1490
  year: 2004
  end-page: 1495
  ident: bib24
  article-title: Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors
  publication-title: Arch. Dermatol.
  contributor:
    fullname: Dummer
– volume: 84
  start-page: 205
  year: 2016
  end-page: 215
  ident: bib15
  article-title: Skin-Specific Unsaturated Fatty Acids Boost the Staphylococcus aureus Innate Immune Response
  publication-title: Infect. Immun.
  contributor:
    fullname: Götz
– volume: 1841
  start-page: 295
  year: 2014
  end-page: 313
  ident: bib14
  article-title: The important role of stratum corneum lipids for the cutaneous barrier function
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Bouwstra
– volume: 21
  year: 2020
  ident: bib10
  article-title: Efficacy and Safety of Biologics for Psoriasis and Psoriatic Arthritis and Their Impact on Comorbidities: A Literature Review
  publication-title: Int. J. Mol. Sci.
  contributor:
    fullname: Tada
– volume: 5
  start-page: 423
  year: 2012
  end-page: 433
  ident: bib12
  article-title: Putting together the psoriasis puzzle: an update on developing targeted therapies
  publication-title: Dis. Model. Mech.
  contributor:
    fullname: Krueger
– volume: 136
  start-page: 487
  year: 2016
  end-page: 496
  ident: bib34
  article-title: IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing
  publication-title: J. Invest. Dermatol.
  contributor:
    fullname: Volk
– volume: 16
  start-page: 143
  year: 2018
  end-page: 155
  ident: bib16
  article-title: The human skin microbiome
  publication-title: Nat. Rev. Microbiol.
  contributor:
    fullname: Segre
– volume: 49
  start-page: D104
  year: 2021
  end-page: D111
  ident: bib20
  article-title: GTRD: an integrated view of transcription regulation
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Kolpakov
– volume: 201
  start-page: 2947
  year: 2018
  end-page: 2958
  ident: bib41
  article-title: IL-4 and IL-13 Guide Early Thymic Progenitors To Mature toward Dendritic Cells
  publication-title: J. Immunol.
  contributor:
    fullname: Zaghouani
– volume: 129
  start-page: 1621
  year: 2012
  end-page: 1627.e3
  ident: bib43
  article-title: Dendritic cells and alveolar macrophages mediate IL-13-induced airway inflammation and chemokine production
  publication-title: J. Allergy Clin. Immunol.
  contributor:
    fullname: Kuperman
– volume: 41
  start-page: 886
  year: 2014
  end-page: 897
  ident: bib4
  article-title: Tissue-resident memory T cells
  publication-title: Immunity
  contributor:
    fullname: Masopust
– volume: 51
  start-page: 10934
  year: 2023
  end-page: 10949
  ident: bib21
  article-title: Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Saez-Rodriguez
– volume: 49
  start-page: 271
  year: 2008
  end-page: 281
  ident: bib17
  article-title: Thematic review series: Skin Lipids. Sebaceous gland lipids: friend or foe?
  publication-title: J. Lipid Res.
  contributor:
    fullname: Thiboutot
– volume: 9
  start-page: 40
  year: 2003
  end-page: 46
  ident: bib27
  article-title: Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
  publication-title: Nat. Med.
  contributor:
    fullname: Mack
– volume: 164
  start-page: 670
  year: 2011
  end-page: 672
  ident: bib25
  article-title: Imiquimod 5% cream induced psoriasis: a case report, summary of the literature and mechanism
  publication-title: Br. J. Dermatol.
  contributor:
    fullname: Levine
– volume: 133
  start-page: 1
  year: 2012
  end-page: 18
  ident: bib2
  article-title: Targeting chemokine receptors in chronic inflammatory diseases: An extensive review
  publication-title: Pharmacol. Ther.
  contributor:
    fullname: Kraneveld
– volume: 23
  start-page: 61
  year: 2022
  end-page: 67
  ident: bib30
  article-title: Dupilumab Facial Redness/Dupilumab Facial Dermatitis: A Guide for Clinicians
  publication-title: Am. J. Clin. Dermatol.
  contributor:
    fullname: Waldman
– volume: 19
  start-page: 1093
  year: 2018
  end-page: 1099
  ident: bib38
  article-title: Tissue signals imprint ILC2 identity with anticipatory function
  publication-title: Nat. Immunol.
  contributor:
    fullname: Erle
– volume: 7
  year: 2017
  ident: bib60
  article-title: QuPath: Open source software for digital pathology image analysis
  publication-title: Sci. Rep.
  contributor:
    fullname: Coleman
– volume: 52
  start-page: 620
  year: 2020
  end-page: 634.e6
  ident: bib45
  article-title: Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation
  publication-title: Immunity
  contributor:
    fullname: Wilhelm
– volume: 182
  start-page: 5836
  year: 2009
  end-page: 5845
  ident: bib9
  article-title: Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
  publication-title: J. Immunol.
  contributor:
    fullname: Prens
– volume: 175
  start-page: 661
  year: 2006
  end-page: 670
  ident: bib22
  article-title: Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3
  publication-title: J. Cell Biol.
  contributor:
    fullname: Segre
– volume: 49
  start-page: 1137
  year: 2008
  end-page: 1146
  ident: bib51
  article-title: Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics
  publication-title: J. Lipid Res.
  contributor:
    fullname: Schwudke
– volume: 17
  start-page: 171
  year: 2012
  end-page: 176
  ident: bib31
  article-title: Thiazolidinediones for plaque psoriasis: a systematic review and meta-analysis
  publication-title: Evid. Based. Med.
  contributor:
    fullname: Malhotra
– volume: 27
  start-page: 115
  year: 2018
  end-page: 123
  ident: bib8
  article-title: Interleukin-17 alters the biology of many cell types involved in the genesis of psoriasis, systemic inflammation and associated comorbidities
  publication-title: Exp. Dermatol.
  contributor:
    fullname: Brunner
– volume: 89
  start-page: 12360
  year: 2017
  end-page: 12368
  ident: bib59
  article-title: Validating Quantitative Untargeted Lipidomics Across Nine Liquid Chromatography-High-Resolution Mass Spectrometry Platforms
  publication-title: Anal. Chem.
  contributor:
    fullname: Fiehn
– volume: 34
  start-page: 174
  year: 2013
  end-page: 181
  ident: bib1
  article-title: The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses
  publication-title: Trends Immunol.
  contributor:
    fullname: Krueger
– volume: 14
  start-page: 564
  year: 2013
  end-page: 573
  ident: bib23
  article-title: Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells
  publication-title: Nat. Immunol.
  contributor:
    fullname: Forbes-Blom
– volume: 45
  start-page: 339
  year: 2022
  end-page: 360
  ident: bib39
  article-title: Neuroimmune Interactions in Peripheral Organs
  publication-title: Annu. Rev. Neurosci.
  contributor:
    fullname: Veiga-Fernandes
– volume: 151
  start-page: 1317
  year: 2023
  end-page: 1328
  ident: bib26
  article-title: Pellino-1 promotes intrinsic activation of skin-resident IL-17A-producing T cells in psoriasis
  publication-title: J. Allergy Clin. Immunol.
  contributor:
    fullname: Lee
– volume: 371
  year: 2021
  ident: bib19
  article-title: Developmental cell programs are co-opted in inflammatory skin disease
  publication-title: Science
  contributor:
    fullname: Dubois
– volume: 55
  start-page: 1891
  year: 2022
  ident: 10.1016/j.celrep.2024.114364_bib5
  article-title: Innate type 2 immunity controls hair follicle commensalism by Demodex mites
  publication-title: Immunity
  doi: 10.1016/j.immuni.2022.08.001
  contributor:
    fullname: Ricardo-Gonzalez
– volume: 151
  start-page: 1317
  year: 2023
  ident: 10.1016/j.celrep.2024.114364_bib26
  article-title: Pellino-1 promotes intrinsic activation of skin-resident IL-17A-producing T cells in psoriasis
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2022.12.823
  contributor:
    fullname: Kim
– volume: 164
  start-page: 670
  year: 2011
  ident: 10.1016/j.celrep.2024.114364_bib25
  article-title: Imiquimod 5% cream induced psoriasis: a case report, summary of the literature and mechanism
  publication-title: Br. J. Dermatol.
  contributor:
    fullname: Patel
– volume: 41
  start-page: 886
  year: 2014
  ident: 10.1016/j.celrep.2024.114364_bib4
  article-title: Tissue-resident memory T cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.12.007
  contributor:
    fullname: Schenkel
– volume: 29
  start-page: 15
  year: 2013
  ident: 10.1016/j.celrep.2024.114364_bib53
  article-title: STAR: ultrafast universal RNA-seq aligner
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
  contributor:
    fullname: Dobin
– volume: 21
  year: 2020
  ident: 10.1016/j.celrep.2024.114364_bib10
  article-title: Efficacy and Safety of Biologics for Psoriasis and Psoriatic Arthritis and Their Impact on Comorbidities: A Literature Review
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21051690
  contributor:
    fullname: Kamata
– volume: 12
  start-page: 323
  year: 2011
  ident: 10.1016/j.celrep.2024.114364_bib54
  article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
  publication-title: BMC Bioinf.
  doi: 10.1186/1471-2105-12-323
  contributor:
    fullname: Li
– volume: 10
  start-page: 755
  year: 2013
  ident: 10.1016/j.celrep.2024.114364_bib56
  article-title: LipidBlast in silico tandem mass spectrometry database for lipid identification
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2551
  contributor:
    fullname: Kind
– volume: 8
  year: 2017
  ident: 10.1016/j.celrep.2024.114364_bib3
  article-title: Langerhans Cells—Programmed by the Epidermis
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.01676
  contributor:
    fullname: Clayton
– volume: 12
  start-page: 523
  year: 2015
  ident: 10.1016/j.celrep.2024.114364_bib57
  article-title: MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3393
  contributor:
    fullname: Tsugawa
– volume: 85
  start-page: 5191
  year: 2013
  ident: 10.1016/j.celrep.2024.114364_bib58
  article-title: MRMPROBS: a data assessment and metabolite identification tool for large-scale multiple reaction monitoring based widely targeted metabolomics
  publication-title: Anal. Chem.
  doi: 10.1021/ac400515s
  contributor:
    fullname: Tsugawa
– volume: 592
  start-page: 128
  year: 2021
  ident: 10.1016/j.celrep.2024.114364_bib36
  article-title: Skin-resident innate lymphoid cells converge on a pathogenic effector state
  publication-title: Nature
  doi: 10.1038/s41586-021-03188-w
  contributor:
    fullname: Bielecki
– volume: 49
  start-page: D104
  year: 2021
  ident: 10.1016/j.celrep.2024.114364_bib20
  article-title: GTRD: an integrated view of transcription regulation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1057
  contributor:
    fullname: Kolmykov
– volume: 51
  start-page: 10934
  year: 2023
  ident: 10.1016/j.celrep.2024.114364_bib21
  article-title: Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad841
  contributor:
    fullname: Müller-Dott
– volume: 82
  start-page: 230
  year: 2020
  ident: 10.1016/j.celrep.2024.114364_bib28
  article-title: Characterizing dupilumab facial redness: A multi-institution retrospective medical record review
  publication-title: J. Am. Acad. Dermatol.
  doi: 10.1016/j.jaad.2019.06.026
  contributor:
    fullname: Waldman
– volume: 27
  start-page: 115
  year: 2018
  ident: 10.1016/j.celrep.2024.114364_bib8
  article-title: Interleukin-17 alters the biology of many cell types involved in the genesis of psoriasis, systemic inflammation and associated comorbidities
  publication-title: Exp. Dermatol.
  doi: 10.1111/exd.13467
  contributor:
    fullname: Krueger
– volume: 5
  start-page: 423
  year: 2012
  ident: 10.1016/j.celrep.2024.114364_bib12
  article-title: Putting together the psoriasis puzzle: an update on developing targeted therapies
  publication-title: Dis. Model. Mech.
  doi: 10.1242/dmm.009092
  contributor:
    fullname: Johnson-Huang
– volume: 31
  start-page: 680
  year: 2020
  ident: 10.1016/j.celrep.2024.114364_bib32
  article-title: Efficacy and safety of pioglitazone for treatment of plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials
  publication-title: J. Dermatolog. Treat.
  doi: 10.1080/09546634.2019.1610552
  contributor:
    fullname: Chang
– volume: 2
  year: 2017
  ident: 10.1016/j.celrep.2024.114364_bib47
  article-title: PPAR-γ promotes type 2 immune responses in allergy and nematode infection
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.aal5196
  contributor:
    fullname: Chen
– volume: 129
  start-page: 1621
  year: 2012
  ident: 10.1016/j.celrep.2024.114364_bib43
  article-title: Dendritic cells and alveolar macrophages mediate IL-13-induced airway inflammation and chemokine production
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2012.01.052
  contributor:
    fullname: Crapster-Pregont
– volume: 136
  start-page: 487
  year: 2016
  ident: 10.1016/j.celrep.2024.114364_bib34
  article-title: IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/JID.2015.406
  contributor:
    fullname: Rak
– volume: 45
  start-page: 339
  year: 2022
  ident: 10.1016/j.celrep.2024.114364_bib39
  article-title: Neuroimmune Interactions in Peripheral Organs
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-111020-105359
  contributor:
    fullname: Klein Wolterink
– volume: 118
  year: 2021
  ident: 10.1016/j.celrep.2024.114364_bib44
  article-title: Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2100749118
  contributor:
    fullname: Zhang
– volume: 210
  start-page: 2951
  year: 2013
  ident: 10.1016/j.celrep.2024.114364_bib33
  article-title: IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20130071
  contributor:
    fullname: Turner
– volume: 19
  start-page: 19
  year: 2019
  ident: 10.1016/j.celrep.2024.114364_bib13
  article-title: The immunological anatomy of the skin
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-018-0084-5
  contributor:
    fullname: Kabashima
– volume: 16
  start-page: 143
  year: 2018
  ident: 10.1016/j.celrep.2024.114364_bib16
  article-title: The human skin microbiome
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2017.157
  contributor:
    fullname: Byrd
– volume: 454
  start-page: 470
  year: 2008
  ident: 10.1016/j.celrep.2024.114364_bib18
  article-title: Integration of metabolism and inflammation by lipid-activated nuclear receptors
  publication-title: Nature
  doi: 10.1038/nature07202
  contributor:
    fullname: Bensinger
– volume: 182
  start-page: 5836
  year: 2009
  ident: 10.1016/j.celrep.2024.114364_bib9
  article-title: Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0802999
  contributor:
    fullname: van der Fits
– volume: 22
  start-page: 1538
  year: 2021
  ident: 10.1016/j.celrep.2024.114364_bib42
  article-title: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-021-01067-0
  contributor:
    fullname: Mayer
– volume: 14
  start-page: 564
  year: 2013
  ident: 10.1016/j.celrep.2024.114364_bib23
  article-title: Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2584
  contributor:
    fullname: Roediger
– volume: 214
  start-page: 3015
  year: 2017
  ident: 10.1016/j.celrep.2024.114364_bib46
  article-title: PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20162069
  contributor:
    fullname: Nobs
– volume: 84
  start-page: 205
  year: 2016
  ident: 10.1016/j.celrep.2024.114364_bib15
  article-title: Skin-Specific Unsaturated Fatty Acids Boost the Staphylococcus aureus Innate Immune Response
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.00822-15
  contributor:
    fullname: Nguyen
– volume: 49
  start-page: 271
  year: 2008
  ident: 10.1016/j.celrep.2024.114364_bib17
  article-title: Thematic review series: Skin Lipids. Sebaceous gland lipids: friend or foe?
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.R700015-JLR200
  contributor:
    fullname: Smith
– volume: 134
  start-page: 261
  year: 2007
  ident: 10.1016/j.celrep.2024.114364_bib50
  article-title: Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles
  publication-title: Development
  doi: 10.1242/dev.02721
  contributor:
    fullname: Kurek
– volume: 201
  start-page: 2947
  year: 2018
  ident: 10.1016/j.celrep.2024.114364_bib41
  article-title: IL-4 and IL-13 Guide Early Thymic Progenitors To Mature toward Dendritic Cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1701186
  contributor:
    fullname: Barik
– volume: 371
  year: 2021
  ident: 10.1016/j.celrep.2024.114364_bib19
  article-title: Developmental cell programs are co-opted in inflammatory skin disease
  publication-title: Science
  doi: 10.1126/science.aba6500
  contributor:
    fullname: Reynolds
– volume: 200
  start-page: 1249
  year: 2018
  ident: 10.1016/j.celrep.2024.114364_bib37
  article-title: Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1700596
  contributor:
    fullname: Soare
– volume: 202
  start-page: 135
  year: 2005
  ident: 10.1016/j.celrep.2024.114364_bib7
  article-title: Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20050500
  contributor:
    fullname: Nestle
– volume: 323
  start-page: 1945
  year: 2020
  ident: 10.1016/j.celrep.2024.114364_bib6
  article-title: Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review
  publication-title: JAMA
  doi: 10.1001/jama.2020.4006
  contributor:
    fullname: Armstrong
– volume: 17
  start-page: 171
  year: 2012
  ident: 10.1016/j.celrep.2024.114364_bib31
  article-title: Thiazolidinediones for plaque psoriasis: a systematic review and meta-analysis
  publication-title: Evid. Based. Med.
  doi: 10.1136/ebmed-2011-100388
  contributor:
    fullname: Malhotra
– volume: 133
  start-page: 1
  year: 2012
  ident: 10.1016/j.celrep.2024.114364_bib2
  article-title: Targeting chemokine receptors in chronic inflammatory diseases: An extensive review
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2011.06.008
  contributor:
    fullname: Koelink
– volume: 19
  start-page: 1093
  year: 2018
  ident: 10.1016/j.celrep.2024.114364_bib38
  article-title: Tissue signals imprint ILC2 identity with anticipatory function
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0201-4
  contributor:
    fullname: Ricardo-Gonzalez
– volume: 176
  start-page: 4385
  year: 2006
  ident: 10.1016/j.celrep.2024.114364_bib48
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.176.7.4385
  contributor:
    fullname: Paintlia
– volume: 1841
  start-page: 295
  year: 2014
  ident: 10.1016/j.celrep.2024.114364_bib14
  article-title: The important role of stratum corneum lipids for the cutaneous barrier function
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbalip.2013.11.006
  contributor:
    fullname: van Smeden
– volume: 34
  start-page: 174
  year: 2013
  ident: 10.1016/j.celrep.2024.114364_bib1
  article-title: The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2012.11.005
  contributor:
    fullname: Lowes
– volume: 17
  start-page: 2108
  year: 2003
  ident: 10.1016/j.celrep.2024.114364_bib49
  article-title: GATA-3: an unexpected regulator of cell lineage determination in skin
  publication-title: Genes Dev.
  doi: 10.1101/gad.1115203
  contributor:
    fullname: Kaufman
– volume: 49
  start-page: 1137
  year: 2008
  ident: 10.1016/j.celrep.2024.114364_bib51
  article-title: Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.D700041-JLR200
  contributor:
    fullname: Matyash
– volume: 89
  start-page: 12360
  year: 2017
  ident: 10.1016/j.celrep.2024.114364_bib59
  article-title: Validating Quantitative Untargeted Lipidomics Across Nine Liquid Chromatography-High-Resolution Mass Spectrometry Platforms
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.7b03404
  contributor:
    fullname: Cajka
– volume: 23
  start-page: 61
  year: 2022
  ident: 10.1016/j.celrep.2024.114364_bib30
  article-title: Dupilumab Facial Redness/Dupilumab Facial Dermatitis: A Guide for Clinicians
  publication-title: Am. J. Clin. Dermatol.
  doi: 10.1007/s40257-021-00646-z
  contributor:
    fullname: Muzumdar
– volume: 9
  start-page: 40
  year: 2003
  ident: 10.1016/j.celrep.2024.114364_bib27
  article-title: Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
  publication-title: Nat. Med.
  doi: 10.1038/nm804
  contributor:
    fullname: Ghoreschi
– volume: 13
  start-page: 399
  year: 2020
  ident: 10.1016/j.celrep.2024.114364_bib35
  article-title: The role of innate lymphoid cells in response to microbes at mucosal surfaces
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-020-0265-y
  contributor:
    fullname: Seo
– volume: 140
  start-page: 1490
  year: 2004
  ident: 10.1016/j.celrep.2024.114364_bib24
  article-title: Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors
  publication-title: Arch. Dermatol.
  doi: 10.1001/archderm.140.12.1490
  contributor:
    fullname: Gilliet
– volume: 11
  year: 2020
  ident: 10.1016/j.celrep.2024.114364_bib40
  article-title: Neural Regulation of Interactions Between Group 2 Innate Lymphoid Cells and Pulmonary Immune Cells
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.576929
  contributor:
    fullname: Chen
– volume: 49
  start-page: W388
  year: 2021
  ident: 10.1016/j.celrep.2024.114364_bib55
  article-title: MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab382
  contributor:
    fullname: Pang
– volume: 9
  start-page: 671
  year: 2012
  ident: 10.1016/j.celrep.2024.114364_bib52
  article-title: NIH Image to ImageJ: 25 years of image analysis
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2089
  contributor:
    fullname: Schneider
– volume: 7
  year: 2017
  ident: 10.1016/j.celrep.2024.114364_bib60
  article-title: QuPath: Open source software for digital pathology image analysis
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-17204-5
  contributor:
    fullname: Bankhead
– volume: 175
  start-page: 661
  year: 2006
  ident: 10.1016/j.celrep.2024.114364_bib22
  article-title: Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200605057
  contributor:
    fullname: de Guzman Strong
– volume: 84
  start-page: 1339
  year: 2021
  ident: 10.1016/j.celrep.2024.114364_bib29
  article-title: Facial and neck erythema associated with dupilumab treatment: A systematic review
  publication-title: J. Am. Acad. Dermatol.
  doi: 10.1016/j.jaad.2021.01.012
  contributor:
    fullname: Jo
– volume: 52
  start-page: 620
  year: 2020
  ident: 10.1016/j.celrep.2024.114364_bib45
  article-title: Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2020.03.003
  contributor:
    fullname: Karagiannis
– volume: 26
  start-page: 380
  year: 2008
  ident: 10.1016/j.celrep.2024.114364_bib11
  article-title: Emollients, moisturizers, and keratolytic agents in psoriasis
  publication-title: Clin. Dermatol.
  doi: 10.1016/j.clindermatol.2008.01.015
  contributor:
    fullname: Fluhr
SSID ssj0000601194
Score 2.455695
Snippet Immunoregulatory mechanisms established in the lymphoid organs are vital for preventing autoimmunity. However, the presence of similar mechanisms in...
SourceID doaj
proquest
crossref
pubmed
elsevier
SourceType Open Website
Aggregation Database
Index Database
Publisher
StartPage 114364
SubjectTerms CP: Immunology
fatty acid metabolism
LXR
PPARγ
psoriasis
tonic type 2 immunity
SummonAdditionalLinks – databaseName: Elsevier Free Content
  dbid: IXB
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhEMiltGnabB9BhVzNxnpZOjahISm0lyaw5CKsV3BT7GXXe8i_74xsb9lDKORoYT2YkWa-keZByJkAO9bVZSh8kAoMlOALHTDvrVa8TEyxssZA4R8_1fWd-L6Qiz1yOcXCoFvlKPsHmZ6l9dgyH6k5XzbN_BcD2wW0U4VekMowlMNcnuMuv1lcbO9ZMN9Imesh4v8Fdpgi6LKbl49_VhETVzKBeXO5EjsaKify31FUzwHRrJCuXpNXI5KkX4fFviF7sT0iB0Ntyae35P4Wk95SvGKljDY5DKR_os2a1tSP9Q1on8lOgXH-cdk1bU9H13UMUqf1pu_-dWwpYEW6fmzaY3J39e328roYCykUHo5wXwCoCkqC5cKjAnXvjNQVk0EnD6ziTkddJmmSAmVWK2Uqhk8mlYzGh5ikcPwd2W-7Np4Q6tW5096YVHojHJg7jgOk0byWSTAWqhkpJuLZ5ZAvw06OZL_tQGyLxLYDsWfkAim8_RezXeeGbvVgR3bbWKaKc1ED3HBCBOUqr4NwqVQuiCBhkGrij93ZPDBU85_pv0zstHCu8LGkbmO3WVuUhQAepTIz8n7g83aRAPIQ2skPL573IznEL7wkZvwT2e9Xm_gZ0E3vTvP2_QuBP_TT
  priority: 102
  providerName: Elsevier
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LSxxBEG58EPAiMTFxjYYWvI5k-jU9BwlRlCWwnlyQXJrpl4wuM7o7C-6_t2oeihDJJddhuqepmur6qrvqK0KOBcSxtkh94rxUEKB4l2iPvLda8TQyxdICC4UnV2o8Fb9v5M0aGXq29gJc_DW0w35S0_ns5Olx9RMM_vQ1V8uF2Twg-yQTSH7LlVgnmwx8IyZ5TXrA3-3NyHEmhhq6dwa_8VEtlf8bV_UeFG1d0uVHst1jSfqrU_4OWQvVJ_Kh6y65-kz-XCPtLcVDVspo2RaCNCtaLmhBXd_hgDat4Cmozt0_1GXV0D55HcvUabFs6teBFQW0SBf3ZbVLppcX1-fjpG-lkDgw4iYBWOWVhNiFBwUO3-ZSZ0x6HR0oi1sddBplHhW4s0KpPGN4aZLJkDsfohSWfyEbVV2FPUKd-mG1y_OYulxYCHgsB1CjeSGjYMxnI5IMwjMPHWOGGVLJ7kwnbIPCNp2wR-QMJfzyLvJdtw_q-a3pzceENGaciwIAhxXCK5s57YWNqbJeeAmTZIN-TA8dOkgAU5X_-PzRoE4DloXXJUUV6uXC4G4I8FGqfES-dnp-WSTAPAR3cv9_LP4b2cIF4Ykx4wdko5kvwyFAncZ-b__eZzT3-4U
  priority: 102
  providerName: Scholars Portal
Title Tonic type 2 immunity is a critical tissue checkpoint controlling autoimmunity in the skin
URI https://dx.doi.org/10.1016/j.celrep.2024.114364
https://www.ncbi.nlm.nih.gov/pubmed/38900635
https://www.proquest.com/docview/3070839569
https://doaj.org/article/e1f7334a224b44d6b7c8d4bf16bd4d54
Volume 43
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1JS8UwEA4iCF7E3edGBK9Fm63pUUVRQU8KDy-h2aAqffJe38F_70zTuhzEi5ccSpdhpsl8k8x8Q8ixgDjWVrnPnJcKAhTvMu2R91YrnkemWF5hofDdvbp-FLdjOf7W6gtzwhI9cFLcSchjwbmowNVYIbyyhdNe2Jgr64WXiQn0lH0LptIajFxmYqiV6xK6XHidBqSoZAIZcrkSP3xRR9n_wyX9Bjk713O1SlZ6zEjPkqxrZCE062QpdZF83yBPD0hvS3EzlTJadwUf7TutZ7Siru9kQNtOwRRM5F7eJnXT0j5JHcvRaTVvJ18PNhRQIZ291M0meby6fLi4zvqWCZmDydpmAJ-8khCj8KDAsdtS6oJJr6MDo3Crg86jLKMCt1UpVRYMD0cKGUrnQ5TC8i2y2EyasEOoU6dWu7KMuSuFhcDGcgAvmlcyCsZ8MSLZoDzzlpgxzJAy9mySsg0q2yRlj8g5avjzXuS17i6AtU1vbfOXtUekGOxjeoiQXD-8qv7j80eDOQ3MIDwWqZowmc8MrnoAE6UqR2Q72flTSIBzCOLk7n8Iv0eWUSDcGWZ8nyy203k4AEjT2sPu74XxZnwO453QHwmg9EY
link.rule.ids 314,780,784,864,2102,2221,3506,24318,27924,27925,45874
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqIgQXxJvlaSSu0RK_Yh9pRbWFthe20oqLFb9QKEpWu9lD_z0zTrJoDwiJqxMn1kwy84098w0hHwTEsa4uQ-GDVBCgBF_ogLy3WvEyMcXKGguFL6_U4lp8WcnVETmdamEwrXK0_YNNz9Z6HJmP0pyvm2b-jUHsAt6pwixIZRjY4TtC6goJ9M9XJ_uNFiQcKXNDRJxQ4IyphC7nefn4axORuZIJJM7lShy4qMzkf-Cp_oZEs0c6e0gejFCSfhpW-4gcxfYxuTs0l7x9Qr4vkfWW4h4rZbTJdSD9LW22tKZ-bHBA-yx3CprzN-uuaXs65q5jlTqtd333Z2JLASzS7U3TPiXXZ5-Xp4ti7KRQePiH-wJQVVASQhceFfh7Z0BOTAadPOiKOx11maRJCrxZrZSpGJ6ZVDIaH2KSwvFn5Ljt2viCUK8-Ou2NSaU3wkG84zhgGs1rmQRjoZqRYhKeXQ-EGXbKJPtpB2FbFLYdhD0jJyjh_b1Id50Hus0PO-rbxjJVnIsa8IYTIihXeR2ES6VyQQQJD6km_diDrwce1fzj9e8ndVr4sfC0pG5jt9taNIaAHqUyM_J80PN-kYDyENvJl__93nfk3mJ5eWEvzq--viL38QruGDP-mhz3m118A1Cnd2_zp_wb8a_3_A
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tonic+type+2+immunity+is+a+critical+tissue+checkpoint+controlling+autoimmunity+in+the+skin&rft.jtitle=Cell+reports+%28Cambridge%29&rft.au=Jeong-Eun+Lee&rft.au=Mina+Kim&rft.au=Sotaro+Ochiai&rft.au=Sung-Hee+Kim&rft.date=2024-07-23&rft.pub=Elsevier&rft.eissn=2211-1247&rft.volume=43&rft.issue=7&rft.spage=114364&rft_id=info:doi/10.1016%2Fj.celrep.2024.114364&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_e1f7334a224b44d6b7c8d4bf16bd4d54
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2211-1247&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2211-1247&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2211-1247&client=summon