Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study

• Published in: Alzheimer disease and associated disorders Vol. 31; no. 2; p. 107
• Main Authors: Koenig, Aaron M, Mechanic-Hamilton, Dawn, Xie, Sharon X, Combs, Martha F, Cappola, Anne R, Xie, Long, Detre, John A, Wolk, David A, Arnold, Steven E
• Format: Journal Article
• Language: English
• Published: United States 01.04.2017
• Subjects: Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - drug therapy; Cognitive Dysfunction - cerebrospinal fluid; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - drug therapy; Cross-Over Studies; Diabetes Mellitus, Type 2 - drug therapy; Female; Humans; Hypoglycemic Agents - therapeutic use; Male; Metformin - therapeutic use; Neuropsychological Tests - statistics & numerical data

Epidemiological studies have identified a robust association between type II diabetes mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with AD. Given this association, we hypothesized that the cen...