Regiochemical observations on the lithiation of 1,2,4-trichlorobenzene and reaction with DMF and oxamide electrophiles in THF

Unusual regiochemistry is observed in the products arising from the reaction of lithiated 1,2,4-trichlorobenzene with N, N-dimethylformamide and tetraalkyloxamides. Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 44; no. 30; pp. 5653 - 5656
Main Authors Burton, Andrew J., Cardwell, Kevin S., Fuchter, Matthew J., Lindvall, Mika K., Patel, Rajnikant, Packham, Terry W., Prodger, Jeremy C., Schilling, Mark B., Walker, Matthew D.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 21.07.2003
Elsevier
Subjects
1,2,4-trichlorobenzene
2,3,5-trichlorobenzaldehyde
Chemistry
Chemistry, Organic
organolithium
Physical Sciences
Science & Technology
α-keto amide
2,3,5-trichlorobenzaldehyde
organolithium
α-keto amide
1,2,4-trichlorobenzene
alpha-keto amide
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Summary:Unusual regiochemistry is observed in the products arising from the reaction of lithiated 1,2,4-trichlorobenzene with N, N-dimethylformamide and tetraalkyloxamides. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(03)01360-1