Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study

• Published in: Journal of clinical psychopharmacology Vol. 38; no. 4; p. 349
• Main Authors: Guo, Michael Y, Etminan, Mahyar, Procyshyn, Ric M, Kim, David D, Samii, Ali, Kezouh, Abbas, Carleton, Bruce C
• Format: Journal Article
• Language: English
• Published: United States 01.08.2018
• Subjects: Antidepressive Agents - adverse effects; Basal Ganglia Diseases - chemically induced; Basal Ganglia Diseases - epidemiology; Bupropion - adverse effects; Case-Control Studies; Citalopram - adverse effects; Duloxetine Hydrochloride - adverse effects; Female; Fluoxetine - adverse effects; Humans; Male; Mianserin - adverse effects; Mianserin - analogs & derivatives; Middle Aged; Paroxetine - adverse effects; Pharmacoepidemiology; Sertraline - adverse effects; United States - epidemiology; Venlafaxine Hydrochloride - adverse effects

Antidepressants are one of the most prescribed classes of medications. A number of case reports have linked these drugs to extrapyramidal symptoms (EPSs), but no large epidemiologic study to date has examined this association. We sought to quantify the association of EPSs with different antidepressa...