Studies towards the synthesis of Fipronil® analogues: improved decarboxylation of α-hydrazonoacid derivatives
The Mannich reaction of hydrazones coupled with a [4+1] cycloaddition with isocyanides has been used for the synthesis of aminopyrazole analogues of Fipronil®. The starting cyanohydrazone was prepared with new experimental conditions for efficient diazonium coupling in fluorinated solvents followed...
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Published in | Tetrahedron letters Vol. 43; no. 46; pp. 8319 - 8321 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
11.11.2002
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The Mannich reaction of hydrazones coupled with a [4+1] cycloaddition with isocyanides has been used for the synthesis of aminopyrazole analogues of Fipronil®. The starting cyanohydrazone was prepared with new experimental conditions for efficient diazonium coupling in fluorinated solvents followed by a new sodium cyanide catalysed decarboxylation.
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(02)01977-9 |