Exploring calcium ion-dependent effect on the intermolecular interaction between human secreted phospholipase A2 and its peptide inhibitors in coronary artery disease

• Published in: Journal of molecular graphics & modelling Vol. 93; p. 107449
• Main Authors: Bo, Guanggan, Cao, Fang, Li, Min, Xing, Junwu, Su, Xiaoye, Zhu, Yunxian, Wu, Dingkun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2019
• Subjects: Calcium ion-dependent effect; Coronary artery disease; Human secreted phospholipase A2; Intermolecular interaction; Peptide inhibitor; Calcium ion-dependent effect; Intermolecular interaction; Human secreted phospholipase A2; Peptide inhibitor; Coronary artery disease; Human secreted phospholipase A

Human secreted phospholipase A2 (hsPLA2) is a small calcium ion (Ca2+)-regulatory protein secreting from platelets, eosinophils and T-lymphocytes, which has been established as an important biomarker and potential target for the diagnosis and therapy of coronary artery disease. Short peptide inhibit...