Nitric oxide donor agents for the treatment of ischemia/reperfusion injury in human subjects: a systematic review

• Published in: Shock (Augusta, Ga.) Vol. 39; no. 3; p. 229
• Main Authors: Roberts, Brian W, Mitchell, Jessica, Kilgannon, J Hope, Chansky, Michael E, Trzeciak, Stephen
• Format: Journal Article
• Language: English
• Published: United States 01.03.2013
• Subjects: Cardiopulmonary Bypass - adverse effects; Humans; Myocardial Infarction - complications; Nitric Oxide Donors - therapeutic use; Organ Transplantation - adverse effects; Reperfusion Injury - drug therapy; Reperfusion Injury - etiology

In animal models, administration of nitric oxide (NO) donor agents has been shown to reduce ischemia/reperfusion (I/R) injury. Our aim was to systematically analyze the biomedical literature to determine the effects of NO-donor agent administration on I/R injury in human subjects. We hypothesized th...