Pulcherrimins A – D, novel diterpene dibenzoates from Caesalpinia pulcherrima with selective activity against DNA repair-deficient yeast mutants
Bioassay-guided fractionation of the MeOH/CH 2Cl 2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B, C and D (1–4). The structures of these compounds including their absolute configuration were established by interpretation of spectral data...
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Published in | Tetrahedron Vol. 53; no. 5; pp. 1583 - 1592 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
03.02.1997
Elsevier |
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Abstract | Bioassay-guided fractionation of the MeOH/CH
2Cl
2 extract of the roots of
Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B, C and D (1–4). The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B (1 and 2) were found to be active in DNA repair-deficient yeast mutant.
Bioassay-guided fractionation of the MeOH/CH
2Cl
2 extract of the roots of
Caesalpinia pulcherrima yielded four novel dibenzoate tetracyclic diterpenes, pulcherrimins A, B, C and D (
1–4_. The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B (
1 and
2)_ were found to be active in DNA repair-deficient yeast mutant. |
---|---|
AbstractList | Bioassay-guided fractionation of the MeOH/CH2Cl2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B, C and D (1-4). The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B (1 and 2) were found to be active in DNA repair-deficient yeast mutant. (C) 1997, Elsevier Science Ltd. Bioassay-guided fractionation of the MeOH/CH 2Cl 2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B, C and D (1–4). The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B (1 and 2) were found to be active in DNA repair-deficient yeast mutant. Bioassay-guided fractionation of the MeOH/CH 2Cl 2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate tetracyclic diterpenes, pulcherrimins A, B, C and D ( 1–4_. The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B ( 1 and 2)_ were found to be active in DNA repair-deficient yeast mutant. |
Author | Reichwein, Rex Freyer, Alan J. Johnson, Randall K. Zuber, Gary Faucette, Leo Lee Webb, R. Bean, Mark F. Patil, Ashok D. |
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Cites_doi | 10.1016/S0031-9422(00)94522-9 10.1021/np50089a014 10.1016/S0031-9422(00)97708-2 10.1351/pac199466102219 |
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Snippet | Bioassay-guided fractionation of the MeOH/CH
2Cl
2 extract of the roots of
Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A,... Bioassay-guided fractionation of the MeOH/CH2Cl2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B,... |
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Title | Pulcherrimins A – D, novel diterpene dibenzoates from Caesalpinia pulcherrima with selective activity against DNA repair-deficient yeast mutants |
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