Pulcherrimins A – D, novel diterpene dibenzoates from Caesalpinia pulcherrima with selective activity against DNA repair-deficient yeast mutants

Bioassay-guided fractionation of the MeOH/CH 2Cl 2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B, C and D (1–4). The structures of these compounds including their absolute configuration were established by interpretation of spectral data...

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Published inTetrahedron Vol. 53; no. 5; pp. 1583 - 1592
Main Authors Patil, Ashok D., Freyer, Alan J., Lee Webb, R., Zuber, Gary, Reichwein, Rex, Bean, Mark F., Faucette, Leo, Johnson, Randall K.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 03.02.1997
Elsevier
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Abstract Bioassay-guided fractionation of the MeOH/CH 2Cl 2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B, C and D (1–4). The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B (1 and 2) were found to be active in DNA repair-deficient yeast mutant. Bioassay-guided fractionation of the MeOH/CH 2Cl 2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate tetracyclic diterpenes, pulcherrimins A, B, C and D ( 1–4_. The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B ( 1 and 2)_ were found to be active in DNA repair-deficient yeast mutant.
AbstractList Bioassay-guided fractionation of the MeOH/CH2Cl2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B, C and D (1-4). The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B (1 and 2) were found to be active in DNA repair-deficient yeast mutant. (C) 1997, Elsevier Science Ltd.
Bioassay-guided fractionation of the MeOH/CH 2Cl 2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B, C and D (1–4). The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B (1 and 2) were found to be active in DNA repair-deficient yeast mutant. Bioassay-guided fractionation of the MeOH/CH 2Cl 2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate tetracyclic diterpenes, pulcherrimins A, B, C and D ( 1–4_. The structures of these compounds including their absolute configuration were established by interpretation of spectral data and CD measurements. Pulcherrimins A and B ( 1 and 2)_ were found to be active in DNA repair-deficient yeast mutant.
Author Reichwein, Rex
Freyer, Alan J.
Johnson, Randall K.
Zuber, Gary
Faucette, Leo
Lee Webb, R.
Bean, Mark F.
Patil, Ashok D.
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Cites_doi 10.1016/S0031-9422(00)94522-9
10.1021/np50089a014
10.1016/S0031-9422(00)97708-2
10.1351/pac199466102219
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Snippet Bioassay-guided fractionation of the MeOH/CH 2Cl 2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A,...
Bioassay-guided fractionation of the MeOH/CH2Cl2 extract of the roots of Caesalpinia pulcherrima yielded four novel dibenzoate diterpenes, pulcherrimins A, B,...
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SubjectTerms Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Title Pulcherrimins A – D, novel diterpene dibenzoates from Caesalpinia pulcherrima with selective activity against DNA repair-deficient yeast mutants
URI https://dx.doi.org/10.1016/S0040-4020(96)01135-0
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