Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status

• Published in: The American journal of surgical pathology Vol. 36; no. 7; p. e1
• Main Authors: Thway, Khin, Fisher, Cyril
• Format: Journal Article
• Language: English
• Published: United States 01.07.2012
• Subjects: Animals; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Gastrointestinal Neoplasms - genetics; Genetic Predisposition to Disease; Histiocytoma, Malignant Fibrous - genetics; Humans; Lung Neoplasms - genetics; Myoepithelioma - genetics; Neoplasms - chemistry; Neoplasms - genetics; Neoplasms - pathology; Oncogene Proteins, Fusion - genetics; Phenotype; Prognosis; Salivary Gland Neoplasms - genetics; Sarcoma, Clear Cell - genetics; Soft Tissue Neoplasms - genetics

EWSR1-CREB1 and EWSR1-ATF1 are gene fusions of which one or both have now been consistently described in 5 histopathologically and behaviorally diverse neoplasms: angiomatoid fibrous histiocytoma, conventional clear cell sarcoma (of tendons and aponeuroses), clear cell sarcoma-like tumor of the gast...