AS101 regulates the Teff/Treg balance to alleviate rabbit autoimmune dacryoadenitis through modulating NFATc2

• Published in: Experimental eye research Vol. 244; p. 109937
• Main Authors: Wang, Xiu, Li, Na, Zhang, Jiawen, Wang, Jiali, Wei, Yankai, Yang, Jun, Sun, Deming, Liu, Lin, Nian, Hong, Wei, Ruihua
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2024
• Subjects: Animals; AS101; Autoimmune dacryoadenitis; Autoimmune Diseases - drug therapy; Autoimmune Diseases - immunology; Autoimmune Diseases - metabolism; Blotting, Western; Cytokines - metabolism; Dacryocystitis - drug therapy; Dacryocystitis - metabolism; Disease Models, Animal; Female; Gene Expression Regulation; Lacrimal Apparatus - metabolism; Lacrimal Apparatus - pathology; NFATC Transcription Factors - genetics; NFATC Transcription Factors - metabolism; NFATc2; Rabbits; Real-Time Polymerase Chain Reaction; Sjogren's Syndrome - drug therapy; T-Lymphocytes, Regulatory - immunology; Th1; Th17; Treg; NFATc2; AS101; Autoimmune dacryoadenitis; Th1; Th17; Treg

Sjögren's syndrome (SS) dry eye can cause ocular surface inflammation and lacrimal gland (LG) damage, leading to discomfort and potential vision problems. The existing treatment options for SS dry eye are currently constrained. We investigated the possible therapeutic effect and the underlying...