Novel ether derivatives of 11-azaartemisinins with high order antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice
[Display omitted] This study investigates cutting-edge synthetic chemistry approaches for designing and producing innovative antimalarial drugs with improved efficacy and fewer adverse effects. Novel amino (–NH2) and hydroxy (–OH) functionalized 11-azaartemisinins 9, 12, and 14 were synthesized alon...
Saved in:
Published in | Bioorganic & medicinal chemistry letters Vol. 103; p. 129700 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
01.05.2024
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | [Display omitted]
This study investigates cutting-edge synthetic chemistry approaches for designing and producing innovative antimalarial drugs with improved efficacy and fewer adverse effects. Novel amino (–NH2) and hydroxy (–OH) functionalized 11-azaartemisinins 9, 12, and 14 were synthesized along with their derivatives 11a, 13a-e, and 15a-b through ART and were tested for their AMA (antimalarial activity) against Plasmodium yoelii via intramuscular (i.m.) and oral routes in Swiss mice. Ether derivative 13c was the most active compound by i.m. route, it has shown 100 % protection at the dose of 12 mg/kg × 4 days and showed 100 % clearance of parasitaemia on day 4 at dose of 6 mg/kg. Amine 11a, ether derivatives 13d, 13e and ether 15a also showed promising antimalarial activity. β-Arteether gave 100 % protection at the dose of 48 mg/kg × 4 days and 20 % protection at 24 mg/kg × 4 days dose by oral route, while it showed 100 % protection at 6 mg/kg × 4 days and no protection at 3 mg/kg × 4 days by i.m. route. |
---|---|
AbstractList | This study investigates cutting-edge synthetic chemistry approaches for designing and producing innovative antimalarial drugs with improved efficacy and fewer adverse effects. Novel amino (-NH2) and hydroxy (-OH) functionalized 11-azaartemisinins 9, 12, and 14 were synthesized along with their derivatives 11a, 13a-e, and 15a-b through ART and were tested for their AMA (antimalarial activity) against Plasmodium yoelii via intramuscular (i.m.) and oral routes in Swiss mice. Ether derivative 13c was the most active compound by i.m. route, it has shown 100 % protection at the dose of 12 mg/kg × 4 days and showed 100 % clearance of parasitaemia on day 4 at dose of 6 mg/kg. Amine 11a, ether derivatives 13d, 13e and ether 15a also showed promising antimalarial activity. β-Arteether gave 100 % protection at the dose of 48 mg/kg × 4 days and 20 % protection at 24 mg/kg × 4 days dose by oral route, while it showed 100 % protection at 6 mg/kg × 4 days and no protection at 3 mg/kg × 4 days by i.m. route. This study investigates cutting-edge synthetic chemistry approaches for designing and producing innovative antimalarial drugs with improved efficacy and fewer adverse effects. Novel amino (-NH ) and hydroxy (-OH) functionalized 11-azaartemisinins 9, 12, and 14 were synthesized along with their derivatives 11a, 13a-e, and 15a-b through ART and were tested for their AMA (antimalarial activity) against Plasmodium yoelii via intramuscular (i.m.) and oral routes in Swiss mice. Ether derivative 13c was the most active compound by i.m. route, it has shown 100 % protection at the dose of 12 mg/kg × 4 days and showed 100 % clearance of parasitaemia on day 4 at dose of 6 mg/kg. Amine 11a, ether derivatives 13d, 13e and ether 15a also showed promising antimalarial activity. β-Arteether gave 100 % protection at the dose of 48 mg/kg × 4 days and 20 % protection at 24 mg/kg × 4 days dose by oral route, while it showed 100 % protection at 6 mg/kg × 4 days and no protection at 3 mg/kg × 4 days by i.m. route. [Display omitted] This study investigates cutting-edge synthetic chemistry approaches for designing and producing innovative antimalarial drugs with improved efficacy and fewer adverse effects. Novel amino (–NH2) and hydroxy (–OH) functionalized 11-azaartemisinins 9, 12, and 14 were synthesized along with their derivatives 11a, 13a-e, and 15a-b through ART and were tested for their AMA (antimalarial activity) against Plasmodium yoelii via intramuscular (i.m.) and oral routes in Swiss mice. Ether derivative 13c was the most active compound by i.m. route, it has shown 100 % protection at the dose of 12 mg/kg × 4 days and showed 100 % clearance of parasitaemia on day 4 at dose of 6 mg/kg. Amine 11a, ether derivatives 13d, 13e and ether 15a also showed promising antimalarial activity. β-Arteether gave 100 % protection at the dose of 48 mg/kg × 4 days and 20 % protection at 24 mg/kg × 4 days dose by oral route, while it showed 100 % protection at 6 mg/kg × 4 days and no protection at 3 mg/kg × 4 days by i.m. route. This study investigates cutting-edge synthetic chemistry approaches for designing and producing innovative antimalarial drugs with improved efficacy and fewer adverse effects. Novel amino (-NH2) and hydroxy (-OH) functionalized 11-azaartemisinins 9, 12, and 14 were synthesized along with their derivatives 11a, 13a-e, and 15a-b through ART and were tested for their AMA (antimalarial activity) against Plasmodium yoelii via intramuscular (i.m.) and oral routes in Swiss mice. Ether derivative 13c was the most active compound by i.m. route, it has shown 100 % protection at the dose of 12 mg/kg x 4 days and showed 100 % clearance of parasitaemia on day 4 at dose of 6 mg/kg. Amine 11a, ether derivatives 13d, 13e and ether 15a also showed promising antimalarial activity. beta-Arteether gave 100 % protection at the dose of 48 mg/kg x 4 days and 20 % protection at 24 mg/kg x 4 days dose by oral route, while it showed 100 % protection at 6 mg/kg x 4 days and no protection at 3 mg/kg x 4 days by i.m. route. |
ArticleNumber | 129700 |
Author | Rathi, Komal Hassam, Mohammad Singh, Chandan Jat, Jawahar L. Puri, Sunil K. Prakash Verma, Ved |
Author_xml | – sequence: 1 givenname: Komal surname: Rathi fullname: Rathi, Komal organization: Department of Chemistry, Banasthali University, Banasthali Newai 304022, Rajasthan, India – sequence: 2 givenname: Mohammad surname: Hassam fullname: Hassam, Mohammad organization: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India – sequence: 3 givenname: Chandan surname: Singh fullname: Singh, Chandan organization: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India – sequence: 4 givenname: Sunil K. surname: Puri fullname: Puri, Sunil K. organization: Parasitology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India – sequence: 5 givenname: Jawahar L. surname: Jat fullname: Jat, Jawahar L. organization: Department of Chemistry, Babasaheb Bhimrao Ambedkar University (A Central University) Vidya Vihar, Raebareli Road, Lucknow 226025, Uttar Pradesh, India – sequence: 6 givenname: Ved surname: Prakash Verma fullname: Prakash Verma, Ved email: vedprakash079@gmail.com organization: Department of Chemistry, Banasthali University, Banasthali Newai 304022, Rajasthan, India |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38479483$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkU2rEzEUQIM88X3oH3AhWQoy9WYmnWbAjZTnBzxUUMFduJO5bW-ZmTyTTEv9E_5lU1rfUswmm3Mu3HuuxcXoRxLiuYKZAlW_3s7awfWzEko9U2WzAHgkrpSudVFpmF-IK2hqKEyjf1yK6xi3AEqD1k_EZWX0otGmuhK_P_kd9ZLShoLsKPAOE-8oSr-SShX4CzEkGjjyyGOUe04bueH1RvqQaYlj4gF7DIy9RJdVTgeJa8xwksPUJ-7CtC4CRY4p0_JLj3HwHU-DPHjqmSWP8uueY5QDO3oqHq-wj_Ts_N-I7-9uvy0_FHef339cvr0rXAWLVJQacK6MIqiwhFa3iAZd54wyuuqqmty8bHQNGusWqJkvlGsarLJW1di28-pGvDzNvQ_-50Qx2byjo77HkfwUbXl0agMLk9HyhLrgYwy0svchLx0OVoE9hrBbewxhjyHsKUSWXpznT-1A3YPy9_IZeHUC9tT6VXRMo6MHLKcqIaPaQH4q0-b_6SWnHNGPSz-NKatvTirlc-6Ygj3rHQdyyXae_7XIH9G_vuc |
Cites_doi | 10.1021/ol802238d 10.1002/ptr.5958 10.1111/jcmm.17940 10.1016/j.bmcl.2021.128522 10.1002/cmdc.200700065 10.1021/jm801484v 10.1016/j.sajb.2022.12.017 10.1155/2022/5628601 10.1016/j.drudis.2009.05.008 10.1016/j.ejmech.2018.12.007 10.1021/jm020142z 10.1021/jm0109816 10.1002/med.21837 10.1021/jm030947m 10.1016/j.bmc.2017.04.041 10.1021/jm030571c 10.1021/jacs.1c02249 10.1021/jm020461q 10.1186/s12936-019-2955-z 10.1021/jm401774f 10.1002/med.10066 10.1128/mr.60.2.301-315.1996 10.1006/expr.1999.4465 10.1126/science.3887571 10.1016/0040-4039(94)02419-C 10.1021/jm00026a012 |
ContentType | Journal Article |
Copyright | 2024 Elsevier Ltd Copyright © 2024 Elsevier Ltd. All rights reserved. |
Copyright_xml | – notice: 2024 Elsevier Ltd – notice: Copyright © 2024 Elsevier Ltd. All rights reserved. |
DBID | 1KM BLEPL DTL NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.bmcl.2024.129700 |
DatabaseName | Index Chemicus Web of Science Core Collection Science Citation Index Expanded PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | Web of Science PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic PubMed Web of Science |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 1KM name: Index Chemicus url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC sourceTypes: Enrichment Source Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology Chemistry |
EISSN | 1464-3405 |
EndPage | 129700 |
ExternalDocumentID | 10_1016_j_bmcl_2024_129700 38479483 001208474800001 S0960894X24001021 |
Genre | Journal Article |
GrantInformation_xml | – fundername: DST-SERB; Department of Science & Technology (India); Science Engineering Research Board (SERB), India grantid: EEQ/2019/000078 – fundername: Department of Science and Technology, New Delhi, India; Department of Science & Technology (India) |
GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATCM AAXUO ABBQC ABFNM ABGSF ABJNI ABLVK ABMAC ABMZM ABUDA ABYKQ ABZDS ACDAQ ACGFS ACIUM ACRLP ADBBV ADECG ADEZE ADUVX AEBSH AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AFZHZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJOXV AJRQY AJSZI AKRWK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CS3 D0L DOVZS EBS EFJIC EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA IHE J1W KOM LCYCR MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SEW SPC SPCBC SSH SSK SSP SSU SSZ T5K YK3 ZMT ~02 ~G- 1KM AAXKI BLEPL DTL LZ2 M29 M2Z M34 M41 AFJKZ NPM .HR 53G 6TJ AAQXK AAYXX ABTAH ABXDB ACNNM ADMUD AFFNX AGRDE AHHHB ASPBG AVWKF AZFZN CITATION EJD FEDTE FGOYB G-2 HEA HMK HMO HMS HMT HVGLF HZ~ R2- SAE SCB SOC SPT WUQ XPP Y6R ZY4 7X8 |
ID | FETCH-LOGICAL-c307t-240a5181e03a20b4baa8acdc81843d36ec5294604a6b0e9571c99a324036abb53 |
IEDL.DBID | AIKHN |
ISICitedReferencesCount | 1 |
ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=001208474800001 |
ISSN | 0960-894X |
IngestDate | Wed Aug 07 11:52:09 EDT 2024 Thu Sep 26 15:33:24 EDT 2024 Wed Oct 23 10:12:53 EDT 2024 Wed Sep 18 07:35:18 EDT 2024 Fri Oct 18 19:59:16 EDT 2024 Sat Apr 06 16:25:37 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | Multidrug-resistant Antimalarial activity rt ART AMA Artemisinin AZA i.m 11-Azaartemisnin HYDROXY-FUNCTIONALIZED 11-AZAARTEMISININS ANTICANCER PEROXIDES STABILITY |
Language | English |
License | Copyright © 2024 Elsevier Ltd. All rights reserved. |
LinkModel | DirectLink |
LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
MergedId | FETCHMERGED-LOGICAL-c307t-240a5181e03a20b4baa8acdc81843d36ec5294604a6b0e9571c99a324036abb53 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0003-2142-2459 |
PMID | 38479483 |
PQID | 2957168078 |
PQPubID | 23479 |
PageCount | 4 |
ParticipantIDs | proquest_miscellaneous_2957168078 webofscience_primary_001208474800001 webofscience_primary_001208474800001CitationCount crossref_primary_10_1016_j_bmcl_2024_129700 pubmed_primary_38479483 elsevier_sciencedirect_doi_10_1016_j_bmcl_2024_129700 |
PublicationCentury | 2000 |
PublicationDate | 2024-05-01 |
PublicationDateYYYYMMDD | 2024-05-01 |
PublicationDate_xml | – month: 05 year: 2024 text: 2024-05-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | OXFORD |
PublicationPlace_xml | – name: OXFORD – name: England |
PublicationTitle | Bioorganic & medicinal chemistry letters |
PublicationTitleAbbrev | BIOORG MED CHEM LETT |
PublicationTitleAlternate | Bioorg Med Chem Lett |
PublicationYear | 2024 |
Publisher | Elsevier Ltd Elsevier |
Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
References | Zyad, Tilaoui, Jaafari, Oukerrou, Mouse (b0090) 2018; 32 Kumari, Karnatak, Singh (b0050) 2019; 163 WHO World Malaria Report 2023. https://www.who.int/news-room/fact-sheets/detail/malaria (accessed March 29, 2023). Klayman (b0015) 1985; 228 O’Neill, Posner (b0035) 2004; 47 Hindley, Ward, Storr (b0070) 2002; 45 (a) 100% suppression of parasitaemia means no parasites were detected in 50 oil immersion microscopic fields, parasites if at all presents were below the detection limit. The parasites present below the detection limit could multiply and eventually could be detected during observation on subsequent days. In such cases though the drug was providing near 100% suppression of the parasitaemia on day 4 but would not provide full protection to the treated mice in the 28 days survival assay. Multidrug-resistant Puri, Singh (b0155) 2000; 94 White (b0030) 2019; 18 Sharifi-Rad, Herrera-Bravo, Semwal (b0100) 2022; 2022 Torok, Ziffer, Meshnick, Pan, Ager (b0110) 1995; 38 Lee, Weyers, Haynes, van der Kooy (b0055) 2023; 153 Singh, Verma, Hassam, Singh, Naikade, Puri (b0135) 2014; 57 used in this study is resistant to chloroquine, mefloquine and halofantrine. (b) 100% protection means all the treated mice survived till day 28. Similarly, 60% protection means three out of five treated mice survived till day 28. were prepared in groundnut oil so as to contain the required amount of the drug (0.3 mg for a dose of 24 mg/kg, 0.15 mg for a dose of 12 mg/kg and 0.075 mg for a dose of 6 mg/kg) in 0.1 ml and administered via oral and intramuscular routes for each dose. Parasitaemia level were recorded from thin blood smears on day 4 and subsequently twice a week till day 28. The treated mice surviving beyond day 28 were recorded as Swiss mice protected by the drug. Torok, Ziffer (b0105) 1995; 36 and Jambou, Legrand, Khim (b0060) 2005; 366 Singh, Verma, Hassam, Krishna, Puri, Singh (b0130) 2008; 10 Posner, Paik, Sur (b0080) 2003; 46 Academic Press: London Meshnick, Taylor, Kamchonwongpaisan (b0065) 1996; 60 Karnatak, Hassam, Singh (b0140) 2022; 58 Grellepois, Chorki, Ourevitch (b0085) 2004; 47 Rosenthal, Chen, Liu (b0095) 2009; 52 The Swiss albino mice used for the present experiments were duly noted and approved by the Institutional Animal Ethics Committee of Central drug research institute (CDRI), Lucknow, UP, India and the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Government of India. Mice were procured from animal breeding facilities at CDRI Lucknow. (a) Peters, W. Techniques for the study of drug response in experimental malaria. In Muraleedharan, Avery (b0045) 2009; 14 Meshnick, Taylor, Kamchonwongpaisan (b0020) 1996; 60 Akash, Abdelkrim, Bayil (b0005) 2023; 27 parasitized RBC on day zero and treatment was administered to a group of five mice at each dose, from day 0 to 3, in two divided doses daily. The drug dilution of compounds Avery, Alvim-Gaston, Vroman (b0075) 2002; 45 Meng, Ma, Lyu (b0025) 2021; 41 Haynes, Wong, Lee (b0115) 2007; 2 , All compounds screened for their biological activity, the purity level of all compounds were above 99%. pp 64-136. (b) In vivo test procedure: The colony bred Swiss albino mice (25 ± 1g) were inoculated with 1X10 Yaremenko, Belyakova, Radulov (b0120) 2021; 143 Jana, Iram, Joice, Liekens, Dehaen (b0125) 2017; 25 Mice treated with β-arteether served as positive control. Tang, Dong, Vennerstrom (b0040) 2004; 24 Avery, MA (WOS:000177913500023) 2002; 45 White, NJ (WOS:000495679000002) 2019; 18 Singh, AS (WOS:000261294300036) 2008; 10 Rosenthal, AS (WOS:000263530200029) 2009; 52 Singh, C (WOS:000333578400023) 2014; 57 TOROK, DS (WOS:A1995QF82700010) 1995; 36 Grellepois, F (WOS:000220038700014) 2004; 47 Jambou, R (WOS:000233777900024) 2005; 366 Meng, YQ (WOS:000663614900001) 2021; 41 (001208474800001.2) 2023 Yaremenko, IA (WOS:000648704100040) 2021; 143 Zyad, A (WOS:000424287300003) 2018; 32 Hindley, S (WOS:000173985400008) 2002; 45 Torok, DS (WOS:A1995TM54500012) 1995; 38 Kumari, A (WOS:000458597300059) 2019; 163 Posner, GH (WOS:000181399100019) 2003; 46 The Swiss albino mice used for the present experiments were duly noted and approved by the Institutional Animal Ethics Committee of Central drug research institute (CDRI), Lucknow, UP, India and the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Government of India. Mice were procured from animal breeding facilities at CDRI Lucknow (001208474800001.29) 1970 Akash, S (WOS:001069360200001) 2023; 27 Muraleedharan, KM (WOS:000269243000010) 2009; 14 Jana, S (WOS:000404087700010) 2017; 25 O'Neill, PM (WOS:000221740900001) 2004; 47 Tang, YQ (WOS:000222199300002) 2004; 24 KLAYMAN, DL (WOS:A1985AHU5100009) 1985; 228 Sharifi-Rad, J (WOS:000860025600002) 2022; 2022 Karnatak, M (WOS:000783518600006) 2022; 58 Haynes, RK (WOS:000250283300009) 2007; 2 Meshnick, SR (WOS:A1996UP08000003) 1996; 60 Lee, BJ (WOS:000906229000001) 2023; 153 Puri, SK (WOS:000084774700002) 2000; 94 Puri (10.1016/j.bmcl.2024.129700_b0155) 2000; 94 10.1016/j.bmcl.2024.129700_b0150 Jana (10.1016/j.bmcl.2024.129700_b0125) 2017; 25 Sharifi-Rad (10.1016/j.bmcl.2024.129700_b0100) 2022; 2022 Hindley (10.1016/j.bmcl.2024.129700_b0070) 2002; 45 10.1016/j.bmcl.2024.129700_b0010 Singh (10.1016/j.bmcl.2024.129700_b0135) 2014; 57 Muraleedharan (10.1016/j.bmcl.2024.129700_b0045) 2009; 14 Zyad (10.1016/j.bmcl.2024.129700_b0090) 2018; 32 Yaremenko (10.1016/j.bmcl.2024.129700_b0120) 2021; 143 Tang (10.1016/j.bmcl.2024.129700_b0040) 2004; 24 Torok (10.1016/j.bmcl.2024.129700_b0110) 1995; 38 Singh (10.1016/j.bmcl.2024.129700_b0130) 2008; 10 10.1016/j.bmcl.2024.129700_b0145 O’Neill (10.1016/j.bmcl.2024.129700_b0035) 2004; 47 Akash (10.1016/j.bmcl.2024.129700_b0005) 2023; 27 Haynes (10.1016/j.bmcl.2024.129700_b0115) 2007; 2 Lee (10.1016/j.bmcl.2024.129700_b0055) 2023; 153 Posner (10.1016/j.bmcl.2024.129700_b0080) 2003; 46 10.1016/j.bmcl.2024.129700_b0160 Avery (10.1016/j.bmcl.2024.129700_b0075) 2002; 45 Rosenthal (10.1016/j.bmcl.2024.129700_b0095) 2009; 52 Kumari (10.1016/j.bmcl.2024.129700_b0050) 2019; 163 Jambou (10.1016/j.bmcl.2024.129700_b0060) 2005; 366 White (10.1016/j.bmcl.2024.129700_b0030) 2019; 18 Meshnick (10.1016/j.bmcl.2024.129700_b0020) 1996; 60 Torok (10.1016/j.bmcl.2024.129700_b0105) 1995; 36 Karnatak (10.1016/j.bmcl.2024.129700_b0140) 2022; 58 Meng (10.1016/j.bmcl.2024.129700_b0025) 2021; 41 Meshnick (10.1016/j.bmcl.2024.129700_b0065) 1996; 60 Grellepois (10.1016/j.bmcl.2024.129700_b0085) 2004; 47 Klayman (10.1016/j.bmcl.2024.129700_b0015) 1985; 228 |
References_xml | – volume: 27 start-page: 3168 year: 2023 end-page: 3188 ident: b0005 article-title: Antimalarial drug discovery against malaria parasites through haplopine modification: an advanced computational approach publication-title: J Cell Mol Med contributor: fullname: Bayil – volume: 52 start-page: 1198 year: 2009 ident: b0095 article-title: Malaria-infected mice are cured by a single Oral dose of new Dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells publication-title: J Med Chem contributor: fullname: Liu – volume: 58 year: 2022 ident: b0140 article-title: Novel hydrazone derivatives of N-amino-11-azaartemisinin with high order of antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in swiss mice via intramuscular route publication-title: Bioorg Med Chem Lett contributor: fullname: Singh – volume: 41 start-page: 3156 year: 2021 end-page: 3181 ident: b0025 article-title: Recent pharmacological advances in the repurposing of artemisinin drugs publication-title: Med Res Rev contributor: fullname: Lyu – volume: 18 start-page: 1 year: 2019 end-page: 3 ident: b0030 article-title: Triple artemisinin-containing combination anti-malarial treatments should be implemented now to delay the emergence of resistance publication-title: Malar J contributor: fullname: White – volume: 47 start-page: 2945 year: 2004 end-page: 2964 ident: b0035 article-title: A medicinal chemistry perspective on artemisinin and related endoperoxides publication-title: J Med Chem contributor: fullname: Posner – volume: 25 start-page: 3671 year: 2017 end-page: 3676 ident: b0125 article-title: Synthesis and anticancer activity of novel aza-artemisinin derivatives publication-title: Bioorg Med Chem Lett contributor: fullname: Dehaen – volume: 46 start-page: 1060 year: 2003 end-page: 1065 ident: b0080 article-title: Orally active, antimalarial, anticancer, artemisinin-derived trioxane Dimers with high stability and efficacy publication-title: J Med Chem contributor: fullname: Sur – volume: 57 start-page: 2489 year: 2014 end-page: 2497 ident: b0135 article-title: New orally active amino-and hydroxy-functionalized 11-Azaartemisinins and their derivatives with high order of Antimalarial activity against multidrug-resistant Plasmodium yoelii in swiss Mice1 publication-title: J Med Chem contributor: fullname: Puri – volume: 32 start-page: 216 year: 2018 end-page: 229 ident: b0090 article-title: More insights into the pharmacological effects of artemisinin publication-title: Phytother Res contributor: fullname: Mouse – volume: 2 start-page: 1464 year: 2007 end-page: 1479 ident: b0115 article-title: Preparation of N-sulphonyl- and N-carbonyl-11-azaartemisinins with greatly enhanced thermal stabilities: in vitro antimalarial activities publication-title: ChemMedChem contributor: fullname: Lee – volume: 143 start-page: 6634 year: 2021 end-page: 6648 ident: b0120 article-title: Marriage of peroxides and nitrogen heterocycles: selective three-component assembly, peroxide-preserving Rearrangement, and stereoelectronic source of unusual stability of bridged azaozonides publication-title: J Am Chem Soc contributor: fullname: Radulov – volume: 14 start-page: 793 year: 2009 end-page: 803 ident: b0045 article-title: Progress in the development of peroxide-based antiparasitic agents publication-title: Drug Discov Today contributor: fullname: Avery – volume: 153 start-page: 21 year: 2023 end-page: 27 ident: b0055 article-title: Discovery of artemisinin in Artemisia annua, its current production, and relevance to sub-Saharan Africa publication-title: S Afr J Bot contributor: fullname: van der Kooy – volume: 366 start-page: 1960 year: 2005 end-page: 1963 ident: b0060 article-title: Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6 publication-title: Res Lett contributor: fullname: Khim – volume: 60 start-page: 301 year: 1996 end-page: 315 ident: b0065 article-title: Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy publication-title: Microbiol Rev contributor: fullname: Kamchonwongpaisan – volume: 45 start-page: 1052 year: 2002 end-page: 1063 ident: b0070 article-title: Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues publication-title: J Med Chem contributor: fullname: Storr – volume: 36 start-page: 829 year: 1995 end-page: 832 ident: b0105 article-title: Synthesis and reactions of 11-Azaartemisinin and derivatives publication-title: Tetrahedron Lett contributor: fullname: Ziffer – volume: 24 start-page: 425 year: 2004 end-page: 448 ident: b0040 article-title: Synthetic peroxides as antimalarials publication-title: Med Res Rev contributor: fullname: Vennerstrom – volume: 38 start-page: 5045 year: 1995 end-page: 5050 ident: b0110 article-title: Synthesis and Antimalarial activities of N-substituted 11-Azaartemisinins publication-title: J Med Chem contributor: fullname: Ager – volume: 45 start-page: 4321 year: 2002 end-page: 4335 ident: b0075 article-title: Structure-activity relationships of the antimalarial agent artemisinin. direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates publication-title: J Med Chem contributor: fullname: Vroman – volume: 10 start-page: 5461 year: 2008 end-page: 5464 ident: b0130 article-title: Amino-and hydroxy-functionalized 11-azaartemisinins and their derivatives publication-title: Org Lett contributor: fullname: Singh – volume: 60 start-page: 301 year: 1996 end-page: 315 ident: b0020 article-title: Artemisinin and the antimalarial endoperoxides: from herbal remedyto targeted chemotherapy publication-title: Microbiol Rev contributor: fullname: Kamchonwongpaisan – volume: 163 start-page: 804 year: 2019 end-page: 829 ident: b0050 article-title: Current scenario of artemisinin and its analogues for antimalarial activity publication-title: Eur J Med Chem contributor: fullname: Singh – volume: 94 start-page: 8 year: 2000 end-page: 14 ident: b0155 article-title: Azithromycin: antimalarial profile against blood and sporozoite-induced infections in mice and monkeys publication-title: Expl. Parasitol. contributor: fullname: Singh – volume: 2022 start-page: 23 year: 2022 ident: b0100 article-title: Artemisia spp.: an update on its chemical composition, pharmacological and toxicological profiles publication-title: Oxid Med Cell Longev contributor: fullname: Semwal – volume: 47 start-page: 1423 year: 2004 end-page: 1433 ident: b0085 article-title: Orally active antimalarials: hydrolytically stable derivatives of 10-trifluromethyl anhydrodihydroartemisinin publication-title: J Med Chem contributor: fullname: Ourevitch – volume: 228 start-page: 1049 year: 1985 end-page: 1055 ident: b0015 article-title: Qinghaosu (artemisinin): an antimalarial drug from China publication-title: Science contributor: fullname: Klayman – volume: 228 start-page: 1049 year: 1985 ident: WOS:A1985AHU5100009 article-title: QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA publication-title: SCIENCE contributor: fullname: KLAYMAN, DL – volume: 24 start-page: 425 year: 2004 ident: WOS:000222199300002 article-title: Synthetic peroxides as antimalarials publication-title: MEDICINAL RESEARCH REVIEWS contributor: fullname: Tang, YQ – volume: 10 start-page: 5461 year: 2008 ident: WOS:000261294300036 article-title: Amino- and Hydroxy-Functionalized 11-Azaartemisinins and Their Derivatives publication-title: ORGANIC LETTERS doi: 10.1021/ol802238d contributor: fullname: Singh, AS – volume: 32 start-page: 216 year: 2018 ident: WOS:000424287300003 article-title: More insights into the pharmacological effects of artemisinin publication-title: PHYTOTHERAPY RESEARCH doi: 10.1002/ptr.5958 contributor: fullname: Zyad, A – volume: 366 start-page: 1960 year: 2005 ident: WOS:000233777900024 article-title: Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6 publication-title: LANCET contributor: fullname: Jambou, R – volume: 38 start-page: 5045 year: 1995 ident: WOS:A1995TM54500012 article-title: Syntheses and antimalarial activities of N-substituted 11-azaartemisinins publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: Torok, DS – volume: 27 start-page: 3168 year: 2023 ident: WOS:001069360200001 article-title: Antimalarial drug discovery against malaria parasites through haplopine modification: An advanced computational approach publication-title: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE doi: 10.1111/jcmm.17940 contributor: fullname: Akash, S – volume: 58 start-page: ARTN 128522 year: 2022 ident: WOS:000783518600006 article-title: Novel hydrazone derivatives of N-amino-11-azaartemisinin with high order of antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice via intramuscular route publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS doi: 10.1016/j.bmcl.2021.128522 contributor: fullname: Karnatak, M – start-page: 64 year: 1970 ident: 001208474800001.29 article-title: Techniques for the study of drug response in experimental malaria publication-title: Chemotherapy and drug resistance in malaria contributor: fullname: The Swiss albino mice used for the present experiments were duly noted and approved by the Institutional Animal Ethics Committee of Central drug research institute (CDRI), Lucknow, UP, India and the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Government of India. Mice were procured from animal breeding facilities at CDRI Lucknow – volume: 2 start-page: 1464 year: 2007 ident: WOS:000250283300009 article-title: Preparation of N-sulfonyl- and N-carbonyl-11-azaartemisinins with greatly enhanced thermal stabilities:: in vitro antimalarial activities publication-title: CHEMMEDCHEM doi: 10.1002/cmdc.200700065 contributor: fullname: Haynes, RK – volume: 36 start-page: 829 year: 1995 ident: WOS:A1995QF82700010 article-title: SYNTHESIS AND REACTIONS OF 11-AZAARTEMISININ AND DERIVATIVES publication-title: TETRAHEDRON LETTERS contributor: fullname: TOROK, DS – volume: 52 start-page: 1198 year: 2009 ident: WOS:000263530200029 article-title: Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm801484v contributor: fullname: Rosenthal, AS – volume: 153 start-page: 1 year: 2023 ident: WOS:000906229000001 article-title: Discovery of artemisinin in Artemisia annua, its current production, and relevance to sub-Saharan Africa publication-title: SOUTH AFRICAN JOURNAL OF BOTANY doi: 10.1016/j.sajb.2022.12.017 contributor: fullname: Lee, BJ – volume: 2022 start-page: ARTN 5628601 year: 2022 ident: WOS:000860025600002 article-title: Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles publication-title: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY doi: 10.1155/2022/5628601 contributor: fullname: Sharifi-Rad, J – volume: 60 start-page: 301 year: 1996 ident: WOS:A1996UP08000003 article-title: Artemisinin and the antimalarial endoperoxides: From herbal remedy to targeted chemotherapy publication-title: MICROBIOLOGICAL REVIEWS contributor: fullname: Meshnick, SR – volume: 94 start-page: 8 year: 2000 ident: WOS:000084774700002 article-title: Azithromycin: Antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys publication-title: EXPERIMENTAL PARASITOLOGY contributor: fullname: Puri, SK – volume: 14 start-page: 793 year: 2009 ident: WOS:000269243000010 article-title: Progress in the development of peroxide-based anti-parasitic agents publication-title: DRUG DISCOVERY TODAY doi: 10.1016/j.drudis.2009.05.008 contributor: fullname: Muraleedharan, KM – volume: 163 start-page: 804 year: 2019 ident: WOS:000458597300059 article-title: Current scenario of artemisinin and its analogues for antimalarial activity publication-title: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1016/j.ejmech.2018.12.007 contributor: fullname: Kumari, A – volume: 45 start-page: 4321 year: 2002 ident: WOS:000177913500023 article-title: Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm020142z contributor: fullname: Avery, MA – year: 2023 ident: 001208474800001.2 publication-title: WHO World Malaria Report – volume: 45 start-page: 1052 year: 2002 ident: WOS:000173985400008 article-title: Mechanism-based design of parasite-targeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm0109816 contributor: fullname: Hindley, S – volume: 41 start-page: 3156 year: 2021 ident: WOS:000663614900001 article-title: Recent pharmacological advances in the repurposing of artemisinin drugs publication-title: MEDICINAL RESEARCH REVIEWS doi: 10.1002/med.21837 contributor: fullname: Meng, YQ – volume: 47 start-page: 1423 year: 2004 ident: WOS:000220038700014 article-title: Orally active antimalarials:: Hydrolytically stable derivatives of 10-trifluoromethyl anhydrodihydroartemisinin publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm030947m contributor: fullname: Grellepois, F – volume: 25 start-page: 3671 year: 2017 ident: WOS:000404087700010 article-title: Synthesis and anticancer activity of novel aza-artemisinin derivatives publication-title: BIOORGANIC & MEDICINAL CHEMISTRY doi: 10.1016/j.bmc.2017.04.041 contributor: fullname: Jana, S – volume: 47 start-page: 2945 year: 2004 ident: WOS:000221740900001 article-title: A medicinal chemistry perspective on artemisinin and related endoperoxides publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm030571c contributor: fullname: O'Neill, PM – volume: 143 start-page: 6634 year: 2021 ident: WOS:000648704100040 article-title: Marriage of Peroxides and Nitrogen Heterocycles: Selective Three-Component Assembly, Peroxide-Preserving Rearrangement, and Stereoelectronic Source of Unusual Stability of Bridged Azaozonides publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/jacs.1c02249 contributor: fullname: Yaremenko, IA – volume: 46 start-page: 1060 year: 2003 ident: WOS:000181399100019 article-title: Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm020461q contributor: fullname: Posner, GH – volume: 18 start-page: ARTN 338 year: 2019 ident: WOS:000495679000002 article-title: Triple artemisinin-containing combination anti-malarial treatments should be implemented now to delay the emergence of resistance publication-title: MALARIA JOURNAL doi: 10.1186/s12936-019-2955-z contributor: fullname: White, NJ – volume: 57 start-page: 2489 year: 2014 ident: WOS:000333578400023 article-title: New Orally Active Amino- and Hydroxy-Functionalized 11-Azaartemisinins and Their Derivatives with High Order of Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii in Swiss Mice publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm401774f contributor: fullname: Singh, C – volume: 24 start-page: 425 year: 2004 ident: 10.1016/j.bmcl.2024.129700_b0040 article-title: Synthetic peroxides as antimalarials publication-title: Med Res Rev doi: 10.1002/med.10066 contributor: fullname: Tang – volume: 47 start-page: 2945 year: 2004 ident: 10.1016/j.bmcl.2024.129700_b0035 article-title: A medicinal chemistry perspective on artemisinin and related endoperoxides publication-title: J Med Chem doi: 10.1021/jm030571c contributor: fullname: O’Neill – volume: 143 start-page: 6634 year: 2021 ident: 10.1016/j.bmcl.2024.129700_b0120 article-title: Marriage of peroxides and nitrogen heterocycles: selective three-component assembly, peroxide-preserving Rearrangement, and stereoelectronic source of unusual stability of bridged azaozonides publication-title: J Am Chem Soc doi: 10.1021/jacs.1c02249 contributor: fullname: Yaremenko – volume: 46 start-page: 1060 year: 2003 ident: 10.1016/j.bmcl.2024.129700_b0080 article-title: Orally active, antimalarial, anticancer, artemisinin-derived trioxane Dimers with high stability and efficacy publication-title: J Med Chem doi: 10.1021/jm020461q contributor: fullname: Posner – volume: 60 start-page: 301 year: 1996 ident: 10.1016/j.bmcl.2024.129700_b0065 article-title: Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy publication-title: Microbiol Rev doi: 10.1128/mr.60.2.301-315.1996 contributor: fullname: Meshnick – ident: 10.1016/j.bmcl.2024.129700_b0145 – volume: 2022 start-page: 23 year: 2022 ident: 10.1016/j.bmcl.2024.129700_b0100 article-title: Artemisia spp.: an update on its chemical composition, pharmacological and toxicological profiles publication-title: Oxid Med Cell Longev doi: 10.1155/2022/5628601 contributor: fullname: Sharifi-Rad – volume: 10 start-page: 5461 year: 2008 ident: 10.1016/j.bmcl.2024.129700_b0130 article-title: Amino-and hydroxy-functionalized 11-azaartemisinins and their derivatives publication-title: Org Lett doi: 10.1021/ol802238d contributor: fullname: Singh – volume: 58 year: 2022 ident: 10.1016/j.bmcl.2024.129700_b0140 article-title: Novel hydrazone derivatives of N-amino-11-azaartemisinin with high order of antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in swiss mice via intramuscular route publication-title: Bioorg Med Chem Lett doi: 10.1016/j.bmcl.2021.128522 contributor: fullname: Karnatak – volume: 14 start-page: 793 year: 2009 ident: 10.1016/j.bmcl.2024.129700_b0045 article-title: Progress in the development of peroxide-based antiparasitic agents publication-title: Drug Discov Today doi: 10.1016/j.drudis.2009.05.008 contributor: fullname: Muraleedharan – ident: 10.1016/j.bmcl.2024.129700_b0160 – volume: 57 start-page: 2489 year: 2014 ident: 10.1016/j.bmcl.2024.129700_b0135 article-title: New orally active amino-and hydroxy-functionalized 11-Azaartemisinins and their derivatives with high order of Antimalarial activity against multidrug-resistant Plasmodium yoelii in swiss Mice1 publication-title: J Med Chem doi: 10.1021/jm401774f contributor: fullname: Singh – volume: 163 start-page: 804 year: 2019 ident: 10.1016/j.bmcl.2024.129700_b0050 article-title: Current scenario of artemisinin and its analogues for antimalarial activity publication-title: Eur J Med Chem doi: 10.1016/j.ejmech.2018.12.007 contributor: fullname: Kumari – volume: 45 start-page: 1052 year: 2002 ident: 10.1016/j.bmcl.2024.129700_b0070 article-title: Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues publication-title: J Med Chem doi: 10.1021/jm0109816 contributor: fullname: Hindley – volume: 153 start-page: 21 year: 2023 ident: 10.1016/j.bmcl.2024.129700_b0055 article-title: Discovery of artemisinin in Artemisia annua, its current production, and relevance to sub-Saharan Africa publication-title: S Afr J Bot doi: 10.1016/j.sajb.2022.12.017 contributor: fullname: Lee – volume: 32 start-page: 216 year: 2018 ident: 10.1016/j.bmcl.2024.129700_b0090 article-title: More insights into the pharmacological effects of artemisinin publication-title: Phytother Res doi: 10.1002/ptr.5958 contributor: fullname: Zyad – ident: 10.1016/j.bmcl.2024.129700_b0150 – volume: 47 start-page: 1423 year: 2004 ident: 10.1016/j.bmcl.2024.129700_b0085 article-title: Orally active antimalarials: hydrolytically stable derivatives of 10-trifluromethyl anhydrodihydroartemisinin publication-title: J Med Chem doi: 10.1021/jm030947m contributor: fullname: Grellepois – volume: 366 start-page: 1960 year: 2005 ident: 10.1016/j.bmcl.2024.129700_b0060 article-title: Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6 publication-title: Res Lett contributor: fullname: Jambou – volume: 27 start-page: 3168 year: 2023 ident: 10.1016/j.bmcl.2024.129700_b0005 article-title: Antimalarial drug discovery against malaria parasites through haplopine modification: an advanced computational approach publication-title: J Cell Mol Med doi: 10.1111/jcmm.17940 contributor: fullname: Akash – volume: 94 start-page: 8 year: 2000 ident: 10.1016/j.bmcl.2024.129700_b0155 article-title: Azithromycin: antimalarial profile against blood and sporozoite-induced infections in mice and monkeys publication-title: Expl. Parasitol. doi: 10.1006/expr.1999.4465 contributor: fullname: Puri – volume: 52 start-page: 1198 year: 2009 ident: 10.1016/j.bmcl.2024.129700_b0095 article-title: Malaria-infected mice are cured by a single Oral dose of new Dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells publication-title: J Med Chem doi: 10.1021/jm801484v contributor: fullname: Rosenthal – volume: 45 start-page: 4321 year: 2002 ident: 10.1016/j.bmcl.2024.129700_b0075 article-title: Structure-activity relationships of the antimalarial agent artemisinin. direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates publication-title: J Med Chem doi: 10.1021/jm020142z contributor: fullname: Avery – volume: 18 start-page: 1 year: 2019 ident: 10.1016/j.bmcl.2024.129700_b0030 article-title: Triple artemisinin-containing combination anti-malarial treatments should be implemented now to delay the emergence of resistance publication-title: Malar J doi: 10.1186/s12936-019-2955-z contributor: fullname: White – volume: 25 start-page: 3671 year: 2017 ident: 10.1016/j.bmcl.2024.129700_b0125 article-title: Synthesis and anticancer activity of novel aza-artemisinin derivatives publication-title: Bioorg Med Chem Lett doi: 10.1016/j.bmc.2017.04.041 contributor: fullname: Jana – volume: 228 start-page: 1049 year: 1985 ident: 10.1016/j.bmcl.2024.129700_b0015 article-title: Qinghaosu (artemisinin): an antimalarial drug from China publication-title: Science doi: 10.1126/science.3887571 contributor: fullname: Klayman – volume: 41 start-page: 3156 year: 2021 ident: 10.1016/j.bmcl.2024.129700_b0025 article-title: Recent pharmacological advances in the repurposing of artemisinin drugs publication-title: Med Res Rev doi: 10.1002/med.21837 contributor: fullname: Meng – volume: 2 start-page: 1464 year: 2007 ident: 10.1016/j.bmcl.2024.129700_b0115 article-title: Preparation of N-sulphonyl- and N-carbonyl-11-azaartemisinins with greatly enhanced thermal stabilities: in vitro antimalarial activities publication-title: ChemMedChem doi: 10.1002/cmdc.200700065 contributor: fullname: Haynes – ident: 10.1016/j.bmcl.2024.129700_b0010 – volume: 60 start-page: 301 year: 1996 ident: 10.1016/j.bmcl.2024.129700_b0020 article-title: Artemisinin and the antimalarial endoperoxides: from herbal remedyto targeted chemotherapy publication-title: Microbiol Rev doi: 10.1128/mr.60.2.301-315.1996 contributor: fullname: Meshnick – volume: 36 start-page: 829 year: 1995 ident: 10.1016/j.bmcl.2024.129700_b0105 article-title: Synthesis and reactions of 11-Azaartemisinin and derivatives publication-title: Tetrahedron Lett doi: 10.1016/0040-4039(94)02419-C contributor: fullname: Torok – volume: 38 start-page: 5045 year: 1995 ident: 10.1016/j.bmcl.2024.129700_b0110 article-title: Synthesis and Antimalarial activities of N-substituted 11-Azaartemisinins publication-title: J Med Chem doi: 10.1021/jm00026a012 contributor: fullname: Torok |
SSID | ssj0014044 |
Score | 2.4818845 |
Snippet | [Display omitted]
This study investigates cutting-edge synthetic chemistry approaches for designing and producing innovative antimalarial drugs with improved... This study investigates cutting-edge synthetic chemistry approaches for designing and producing innovative antimalarial drugs with improved efficacy and fewer... |
Source | Web of Science |
SourceID | proquest crossref pubmed webofscience elsevier |
SourceType | Aggregation Database Index Database Enrichment Source Publisher |
StartPage | 129700 |
SubjectTerms | 11-Azaartemisnin Antimalarial activity Artemisinin Chemistry Chemistry, Medicinal Chemistry, Organic Life Sciences & Biomedicine Multidrug-resistant Pharmacology & Pharmacy Physical Sciences Science & Technology |
Title | Novel ether derivatives of 11-azaartemisinins with high order antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice |
URI | https://dx.doi.org/10.1016/j.bmcl.2024.129700 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=001208474800001 https://www.ncbi.nlm.nih.gov/pubmed/38479483 https://search.proquest.com/docview/2957168078 |
Volume | 103 |
WOS | 001208474800001 |
WOSCitedRecordID | wos001208474800001 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9RAEB_aK6gvolc_zo8yQvFF0svHJtk8HoflVHoItXBvYXeTlJQmKb1cpT74L_gvO7NJDsUi4mOSXdhkJjO_3Zn5DcChil2ppI4dTwvaoGhTOFqRMRQ6ck2SSxPb1gkny2hxJj6uwtUOzIdaGE6r7G1_Z9Otte7vTPuvOb0qy-kpg2-ZiBVnQXKD6l3YI3ckxAj2Zh8-LZbbYIJwbU9XHu_whL52pkvz0pXhCIQvjsjzxVzodrd_-hN_3umqrFs6fgQPezyJs27Jj2Enr8ewP6tpL13d4lu0GZ726HwM9-dDd7cx3Dvpg-r78GPZ3OSXaCt_MSONvLFk4GtsCvQ8R31TnPdJE7mXxBr55BaZ5RgtbSeSaMpK0QaZNBm5TIK7UaA6VzS4RZuwmF1vzh3a1zNWrVv8TIi9arJyU-Ftk1-WJZY1nn4lFcCK7NYTODt-_2W-cPo-DY4hC9FygEaFhBRyN1C-q4VWSiqTGcm9ZLIgyk3oJyJyhYq0mydh7JkkUZYJMFJah8FTGNVNnT8HdJVfFIUxoSTY4RWR1ISHstgr_EiGIosn8G6QTnrV0XGkQ57aRcqyTFmWaSfLCYSDANPflColf_HXeW8Gaaf0dTmEouq82axTn1cfMUf_BJ51arBdRyCZrV8GEzj8VS-2z22dMo0R0oZUJuD9y7B5T9XOFAXti_98oZfwgK-6RM1XMGqvN_lrAlOtPoDdo-_eQf_L_AQ1Ah4X |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa9RAEB5qBeuL6FXr-XOF4ouklx-bZPNYDsupvUNoC_e27G42JdIkpZer1Af_Bf9lZzbJoVhEfL1sYC8zmfk28803APsq9YUSOvUCzfGAok3haYXBkOvEN5kVJnWjE-aLZHbGPy7j5RZMh14YolX2sb-L6S5a979M-qc5uSzLyQmBb5HxJbEgaUD1HbhLaIB4XQffNzwPko9xGlK42qPlfedMR_LSlaH6Q8gPMO-l1OZ2e3b6E33emqhcUjp6CA96NMkOuw0_gi1bj2D3sMaTdHXD3jLH73QfzkewMx1mu43g3rwvqe_Cj0VzbS-Y6_tlOfrjtZMCX7GmYEHgqW-KWJ94I02SWDH6bstI45g50U6Ghikrhcdj9GNGTRI0i4Kpc4WLW-boivnV-tzDUz0h1bplnxGvV01erit209iLsmRlzU6-ogOwCqPWYzg7en86nXn9lAbPYHxoqTyjYsQJ1o9U6GuulRLK5EbQJJk8SqyJw4wnPleJ9m0Wp4HJMuV0ABOldRw9ge26qe1TYL4Ki6IwJhYIOoIiERrRUJ4GRZiImOfpGN4N1pGXnRiHHFhqXyTZUpItZWfLMcSDAeVvLiUxW_z1vjeDtSU-XSqgqNo265UMafcJKfSPYa9zg80-IkFa_SIaw_6vfrG57rqUcQ0XrqAyhuBflk17oXYSKGif_ecfeg07s9P5sTz-sPj0HO7TlY6y-QK226u1fYmwqtWv3GvzE8WXHuw |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+ether+derivatives+of+11-azaartemisinins+with+high+order+antimalarial+activity+against+multidrug-resistant+Plasmodium+yoelii+in+Swiss+mice&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.au=Rathi%2C+Komal&rft.au=Hassam%2C+Mohammad&rft.au=Singh%2C+Chandan&rft.au=Puri%2C+Sunil+K.&rft.date=2024-05-01&rft.pub=Elsevier+Ltd&rft.issn=0960-894X&rft.eissn=1464-3405&rft.volume=103&rft_id=info:doi/10.1016%2Fj.bmcl.2024.129700&rft.externalDocID=S0960894X24001021 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0960-894X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0960-894X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0960-894X&client=summon |