Photo-Crosslinkable Double-Network Hyaluronic Acid Based Hydrogel Dressing

Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility and enzymatic degradability. In this paper a photo-crosslinking double-network hyaluronic acid-based hydrogel dressing was proposed. Hyaluronic acid can be UV-crosslinked by modifi...

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Published inMaterials science forum Vol. 982; pp. 59 - 66
Main Authors Zhang, Hong Bo, Ding, Yu Long, Yin, Rui Xue, Zhang, Wen Jun
Format Journal Article
LanguageEnglish
Published Pfaffikon Trans Tech Publications Ltd 01.03.2020
Subjects
Acids
Biocompatibility
Biological effects
Biomedical materials
Crosslinking
Degradation
Fibroblasts
Hyaluronic acid
Hydrogels
Rheological properties
Storage modulus
Swelling ratio
Biocompatibility
Double Network Cross-Linking
Biodegradable
Hyaluronic Acid
Photocrosslinking
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Abstract Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility and enzymatic degradability. In this paper a photo-crosslinking double-network hyaluronic acid-based hydrogel dressing was proposed. Hyaluronic acid can be UV-crosslinked by modification with methacrylic anhydride (HA-MA) and disulfide-crosslinked by modification with 3,3'-dithiobis (propionylhydrazide) (DTP) (HA-SH). The mixings of these two materials at different ratios were produced. All the samples can be quickly gelled at 365 nm for 10 s. The rheological tests show that the storage modulus (G') of the double network (HA-SH/HA-MA) hydrogel is increased with the increase of HA-SH content. The HA-SH/HA-MA hydrogel has porous structure, high swelling ratio and Controlled degradation rate. In vitro degradation tests show that the ratio of HA-SH/HA-MA ratio was 9:1 (S9M1) in 100 U/ml hyaluronidase (Hase) degraded by 89.91±2.26% at 11d. The cytocompatibility of HA-SH/HA-MA hydrogels was proved by Live/Dead stainings and CCK-8 assays in the human dermis fibroblasts (HDF) cells test. All these results highlight the biological potential of the HA-SH/HA-MA hydrogels for DFU intervention.
AbstractList Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility and enzymatic degradability. In this paper a photo-crosslinking double-network hyaluronic acid-based hydrogel dressing was proposed. Hyaluronic acid can be UV-crosslinked by modification with methacrylic anhydride (HA-MA) and disulfide-crosslinked by modification with 3,3'-dithiobis (propionylhydrazide) (DTP) (HA-SH). The mixings of these two materials at different ratios were produced. All the samples can be quickly gelled at 365 nm for 10 s. The rheological tests show that the storage modulus (G') of the double network (HA-SH/HA-MA) hydrogel is increased with the increase of HA-SH content. The HA-SH/HA-MA hydrogel has porous structure, high swelling ratio and Controlled degradation rate. In vitro degradation tests show that the ratio of HA-SH/HA-MA ratio was 9:1 (S9M1) in 100 U/ml hyaluronidase (Hase) degraded by 89.91±2.26% at 11d. The cytocompatibility of HA-SH/HA-MA hydrogels was proved by Live/Dead stainings and CCK-8 assays in the human dermis fibroblasts (HDF) cells test. All these results highlight the biological potential of the HA-SH/HA-MA hydrogels for DFU intervention.
Author Zhang, Hong Bo
Yin, Rui Xue
Zhang, Wen Jun
Ding, Yu Long
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  fullname: Zhang, Hong Bo
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  organization: East China University of Science and Technology
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  surname: Ding
  fullname: Ding, Yu Long
  email: 1105388050@qq.com
  organization: East China University of Science and Technology
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  fullname: Yin, Rui Xue
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  organization: East China University of Science and Technology
– givenname: Wen Jun
  surname: Zhang
  fullname: Zhang, Wen Jun
  email: wjz485@mail.usask.ca
  organization: University of Saskatchewan
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10.1016/j.biomaterials.2004.04.024
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10.1021/acsami.8b07120
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10.1039/c7tb01026e
10.1016/j.bbadis.2013.10.009
10.1016/S0094-1298(02)00070-6
10.18433/j3k89d
10.3390/jfb9020038
10.1163/156856200743805
10.1016/j.biomaterials.2012.01.007
10.5935/0103-5053.20150115
10.1021/bm025603c
10.1016/j.bioactmat.2017.09.002
10.3390/ma11112128
10.1016/j.ijbiomac.2015.10.057
10.1016/j.biomaterials.2005.01.003
10.1016/j.injury.2006.02.035
10.1016/s0142-9612(02)00100-x
10.1016/j.biomaterials.2016.04.036
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Keywords Biocompatibility
Double Network Cross-Linking
Biodegradable
Hyaluronic Acid
Photocrosslinking
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  doi: 10.1016/j.biomaterials.2005.01.003
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  doi: 10.1016/j.injury.2006.02.035
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  doi: 10.1016/s0142-9612(02)00100-x
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SubjectTerms Acids
Biocompatibility
Biological effects
Biomedical materials
Crosslinking
Degradation
Fibroblasts
Hyaluronic acid
Hydrogels
Rheological properties
Storage modulus
Swelling ratio
Title Photo-Crosslinkable Double-Network Hyaluronic Acid Based Hydrogel Dressing
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