Genotype × Environment Interaction in Psychiatric Genetics: Deep Truth or Thin Ice?

• Published in: Twin research and human genetics Vol. 20; no. 3; pp. 187 - 196
• Main Author: Eaves, Lindon
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.06.2017
• Subjects: Behavior; Check lists; Computer Simulation; Diseases in Twins - genetics; Diseases in Twins - physiopathology; Endorsements; Environmental factors; Epidemiology; Gene-Environment Interaction; Genetic analysis; Genetic transformation; Genotype; Genotype & phenotype; Genotype-environment interactions; Genotypes; Humans; Liability; Mental disorders; Mental Disorders - genetics; Mental Disorders - physiopathology; Models, Theoretical; Random variables; Risk Factors; Twins; Twins, Dizygotic - genetics; Twins, Monozygotic - genetics; psychometrics; twins; G × E interaction; psychiatric genetics

Background: There continues to be significant investment in the detection of genotype × environment interaction (G × E) in psychiatric genetics. The implications of the method of assessment for the genetic analysis of psychiatric disorders are examined for simulated twin data on symptom scores and e...