Synthesis, conformational properties, and synthetic applications of novel optically pure alpha,alpha-disubstituted (R)- and (S)-glycines ('alpha-chimeras') combining side chains of Asp, Glu, Leu, Phe, Ser, and Val

• Published in: Helvetica chimica acta Vol. 79; no. 5; pp. 1315 - 1337
• Main Authors: Obrecht, D, Abrecht, C, Altorfer, M, Bohdal, U, Grieder, A, Kleber, M, Pfyffer, P, Muller, K
• Format: Journal Article
• Language: English
• Published: BASEL NEW SWISS CHEMICAL SOC 07.08.1996
• Subjects: Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; BETA-TURNS; AMINO-ACIDS; SECONDARY STRUCTURE; EXTENDED STRUCTURES; L-ALA-OME; LINEAR PEPTIDES; DISUBSTITUTED GLYCINES; TRIPEPTIDE MODELS; SOLID-STATE; METHYL-ESTER

A series of novel open-chain and cyclic conformationally constrained alpha,alpha-disubstituted (R)- and (S)-glycine derivatives ('alpha-chimeras') combining side chains of Asp, Glu, Leu, Phe, Ser, and Val have been efficiently synthesized by using alpha-alkylation of racemic 4-monosubstitu...