α1-3/4 fucosylation at Asn 241 of β-haptoglobin is a novel marker for colon cancer: A combinatorial approach for development of glycan biomarkers

• Published in: International journal of cancer Vol. 130; no. 10; pp. 2366 - 2376
• Main Authors: Park, Seung-Yeol, Lee, Sung-Hyeon, Kawasaki, Nana, Itoh, Satsuki, Kang, Keunsoo, Hee Ryu, Soo, Hashii, Noritaka, Kim, Jin-Man, Kim, Ji-Yeon, Hoe Kim, Jung
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.05.2012; Wiley-Blackwell
• Subjects: Aged; Asparagine; Biological and medical sciences; Biomarkers, Tumor - analysis; Colon - metabolism; colon cancer; Colonic Neoplasms - diagnosis; Colonic Neoplasms - metabolism; Female; Fucose - metabolism; Gastroenterology. Liver. Pancreas. Abdomen; Glycosylation; haptoglobin; Haptoglobins - chemistry; Haptoglobins - metabolism; Humans; Inflammatory Bowel Diseases - metabolism; lectin blotting; Male; mass spectrometry; Medical sciences; microarray; Polysaccharides - metabolism; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Human; Biological marker; Exploration; Malignant tumor; Carcinogenesis; Glycan; Colonic disease; lectin blotting; microarray; Colon cancer; Cancerology; Haptoglobin; Tumor progression; Fucosylation; Digestive diseases; Intestinal disease; Mass spectrometry; Cancer

Aberrant glycosylation has been observed in many types of cancer, but the mechanism of glycosylation change is still poorly understood. To elucidate relationships between glycosylation and colon cancer progression, we analyzed glycosylation status of β‐haptoglobin (β‐Hp) obtained from 46 cancer pati...