Association of the Nicotinic Receptor α7 Subunit Gene (CHRNA7) with Schizophrenia and Visual Backward Masking
The nicotinic system is involved in the pathophysiology of schizophrenia. However, very little is known about its genetic basis and how it relates to clinical symptoms and potentially pharmacological intervention. Here, we investigated five single nucleotide polymorphisms (SNPs) [rs3826029] [rs23375...
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| Published in | Frontiers in psychiatry Vol. 4; p. 133 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-0640 1664-0640 |
| DOI | 10.3389/fpsyt.2013.00133 |
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| Abstract | The nicotinic system is involved in the pathophysiology of schizophrenia. However, very little is known about its genetic basis and how it relates to clinical symptoms and potentially pharmacological intervention. Here, we investigated five single nucleotide polymorphisms (SNPs) [rs3826029] [rs2337506] [rs982574] [rs904952] [rs2337980] of the cholinergic nicotinic receptor gene, alpha 7 subunit (CHRNA7) and their association to schizophrenia. We found an association with rs904952 (p = 0.009) in a German sample of 224 schizophrenic patients and 224 healthy control subjects. The same trend was shown in an independent Georgian sample of 50 schizophrenic patients, 57 first order unaffected relatives, and 51 healthy controls. In addition, visual backward masking (VBM), a sensitive test for early visual information processing, was assessed in the Georgian sample. In line with prior studies, VBM performance deficits were much more pronounced in schizophrenic patients and their unaffected relatives compared to healthy controls (schizophrenic patients: 156 ms; unaffected relatives: 60 ms; healthy controls: 33 ms). VBM was strongly correlated with SNP rs904952 (H[2] = 7.3, p = 0.026). Our results further support the notion that changes in the nicotinic system are involved in schizophrenia and open the avenue for pharmacological intervention. |
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| AbstractList | The nicotinic system is involved in the pathophysiology of schizophrenia. However, very little is known about its genetic basis and how it relates to clinical symptoms and potentially pharmacological intervention. Here, we investigated five single nucleotide polymorphisms (SNPs) [rs3826029] [rs2337506] [rs982574] [rs904952] [rs2337980] of the cholinergic nicotinic receptor gene, alpha 7 subunit (CHRNA7) and their association to schizophrenia. We found an association with rs904952 (p=0.009) in a German sample of 224 schizophrenic patients and 224 healthy control subjects. The same trend was shown in an independent Georgian sample of 50 schizophrenic patients, 57 first order unaffected relatives, and 51 healthy controls. In addition, visual backward masking (VBM), a sensitive test for early visual information processing, was assessed in the Georgian sample. In line with prior studies, VBM performance deficits were much more pronounced in schizophrenic patients and their unaffected relatives compared to healthy controls (schizophrenic patients: 156 ms; unaffected relatives: 60 ms; healthy controls: 33 ms). VBM was strongly correlated with SNP rs904952 (H[2]=7.3, p=0.026). Our results further support the notion that changes in the nicotinic system are involved in schizophrenia and open the avenue for pharmacological intervention. The nicotinic system is involved in the pathophysiology of schizophrenia. However, very little is known about its genetic basis and how it relates to clinical symptoms and potentially pharmacological intervention. Here, we investigated five single nucleotide polymorphisms (SNPs) [rs3826029] [rs2337506] [rs982574] [rs904952] [rs2337980] of the cholinergic nicotinic receptor gene, alpha 7 subunit (CHRNA7) and their association to schizophrenia. We found an association with rs904952 ( p = 0.009) in a German sample of 224 schizophrenic patients and 224 healthy control subjects. The same trend was shown in an independent Georgian sample of 50 schizophrenic patients, 57 first order unaffected relatives, and 51 healthy controls. In addition, visual backward masking (VBM), a sensitive test for early visual information processing, was assessed in the Georgian sample. In line with prior studies, VBM performance deficits were much more pronounced in schizophrenic patients and their unaffected relatives compared to healthy controls (schizophrenic patients: 156 ms; unaffected relatives: 60 ms; healthy controls: 33 ms). VBM was strongly correlated with SNP rs904952 (H[2] = 7.3, p = 0.026). Our results further support the notion that changes in the nicotinic system are involved in schizophrenia and open the avenue for pharmacological intervention. The nicotinic system is involved in the pathophysiology of schizophrenia. However, very little is known about its genetic basis and how it relates to clinical symptoms and potentially pharmacological intervention. Here, we investigated five single nucleotide polymorphisms (SNPs) [rs3826029] [rs2337506] [rs982574] [rs904952] [rs2337980] of the cholinergic nicotinic receptor gene, alpha 7 subunit (CHRNA7) and their association to schizophrenia. We found an association with rs904952 (p = 0.009) in a German sample of 224 schizophrenic patients and 224 healthy control subjects. The same trend was shown in an independent Georgian sample of 50 schizophrenic patients, 57 first order unaffected relatives, and 51 healthy controls. In addition, visual backward masking (VBM), a sensitive test for early visual information processing, was assessed in the Georgian sample. In line with prior studies, VBM performance deficits were much more pronounced in schizophrenic patients and their unaffected relatives compared to healthy controls (schizophrenic patients: 156 ms; unaffected relatives: 60 ms; healthy controls: 33 ms). VBM was strongly correlated with SNP rs904952 (H[2] = 7.3, p = 0.026). Our results further support the notion that changes in the nicotinic system are involved in schizophrenia and open the avenue for pharmacological intervention.The nicotinic system is involved in the pathophysiology of schizophrenia. However, very little is known about its genetic basis and how it relates to clinical symptoms and potentially pharmacological intervention. Here, we investigated five single nucleotide polymorphisms (SNPs) [rs3826029] [rs2337506] [rs982574] [rs904952] [rs2337980] of the cholinergic nicotinic receptor gene, alpha 7 subunit (CHRNA7) and their association to schizophrenia. We found an association with rs904952 (p = 0.009) in a German sample of 224 schizophrenic patients and 224 healthy control subjects. The same trend was shown in an independent Georgian sample of 50 schizophrenic patients, 57 first order unaffected relatives, and 51 healthy controls. In addition, visual backward masking (VBM), a sensitive test for early visual information processing, was assessed in the Georgian sample. In line with prior studies, VBM performance deficits were much more pronounced in schizophrenic patients and their unaffected relatives compared to healthy controls (schizophrenic patients: 156 ms; unaffected relatives: 60 ms; healthy controls: 33 ms). VBM was strongly correlated with SNP rs904952 (H[2] = 7.3, p = 0.026). Our results further support the notion that changes in the nicotinic system are involved in schizophrenia and open the avenue for pharmacological intervention. |
| Author | Roinishvili, Maya Richter, Sarina Neumann, Konrad Brand, Andreas Bakanidze, George Chkonia, Eka Kitzrow, Werner Herzog, Michael H. Puls, Imke |
| AuthorAffiliation | 4 Department of Psychiatry, Tbilisi State Medical University , Tbilisi , Georgia 2 Department of Behaviour and Cognitive Functions, I. Beritashvili Institute of Physiology , Tbilisi , Georgia 5 Institute of Biometry and Clinical Epidemiology, CCM, Charite University , Berlin , Germany 3 Institute of Cognitive Neurosciences, Agricultural University of Georgia , Tbilisi , Georgia 6 Laboratory of Psychophysics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL) , Lausanne , Switzerland 7 Center for Psychiatry and Psychotherapy, Klinikum Bremen-Ost , Bremen , Germany 1 Genetic Section, Department of Psychiatry and Psychotherapy, CCM, Charité University Medicine , Berlin , Germany |
| AuthorAffiliation_xml | – name: 2 Department of Behaviour and Cognitive Functions, I. Beritashvili Institute of Physiology , Tbilisi , Georgia – name: 1 Genetic Section, Department of Psychiatry and Psychotherapy, CCM, Charité University Medicine , Berlin , Germany – name: 3 Institute of Cognitive Neurosciences, Agricultural University of Georgia , Tbilisi , Georgia – name: 5 Institute of Biometry and Clinical Epidemiology, CCM, Charite University , Berlin , Germany – name: 6 Laboratory of Psychophysics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL) , Lausanne , Switzerland – name: 4 Department of Psychiatry, Tbilisi State Medical University , Tbilisi , Georgia – name: 7 Center for Psychiatry and Psychotherapy, Klinikum Bremen-Ost , Bremen , Germany |
| Author_xml | – sequence: 1 givenname: George surname: Bakanidze fullname: Bakanidze, George – sequence: 2 givenname: Maya surname: Roinishvili fullname: Roinishvili, Maya – sequence: 3 givenname: Eka surname: Chkonia fullname: Chkonia, Eka – sequence: 4 givenname: Werner surname: Kitzrow fullname: Kitzrow, Werner – sequence: 5 givenname: Sarina surname: Richter fullname: Richter, Sarina – sequence: 6 givenname: Konrad surname: Neumann fullname: Neumann, Konrad – sequence: 7 givenname: Michael H. surname: Herzog fullname: Herzog, Michael H. – sequence: 8 givenname: Andreas surname: Brand fullname: Brand, Andreas – sequence: 9 givenname: Imke surname: Puls fullname: Puls, Imke |
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| Copyright | Copyright © 2013 Bakanidze, Roinishvili, Chkonia, Kitzrow, Richter, Neumann, Herzog, Brand and Puls. 2013 |
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| Keywords | genetics of schizophrenia visual masking nicotinic receptor endophenotypes CHRNA7 verniers |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Filippo Drago, University of Catania, Italy This article was submitted to Molecular Psychiatry, a section of the journal Frontiers in Psychiatry. Reviewed by: Ju Wang, University of Virginia, USA; Emilio Clementi, University of Milano, Italy |
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| SubjectTerms | CHRNA7 Endophenotypes genetics of schizophrenia nicotinic receptor Psychiatry Verniers Visual Masking |
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| Title | Association of the Nicotinic Receptor α7 Subunit Gene (CHRNA7) with Schizophrenia and Visual Backward Masking |
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