miR-194 Accelerates Apoptosis of Aβ1–42-Transduced Hippocampal Neurons by Inhibiting Nrn1 and Decreasing PI3K/Akt Signaling Pathway Activity

• Published in: Genes Vol. 10; no. 4; p. 313
• Main Authors: Wang, Tingting, Cheng, Yaling, Han, Haibin, Liu, Jie, Tian, Bo, Liu, Xiaocui
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 21.04.2019; MDPI
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Alzheimer's disease; Apoptosis; BAX protein; Bcl-2 protein; Binding sites; Caspase-3; Cell cycle; Flow cytometry; Hippocampus; Immunofluorescence; MicroRNAs; Neurons; Pathogenesis; Peptides; Signal transduction; United Kingdom > UK; United States > US; Japan

This article explores the mechanism of miR-194 on the proliferation and apoptosis of Aβ1–42-transduced hippocampal neurons. Aβ1–42-transduced hippocampal neuron model was established by inducing hippocampal neurons with Aβ1–42. MTT assay and flow cytometry were used to detect the viability and apopt...