Uptake of a cell permeable G7-18NATE construct into cells and binding with the Grb7-SH2 domain

• Published in: Peptide Science Vol. 96; no. 2; pp. 181 - 188
• Main Authors: Ambaye, Nigus D., Lim, Reece C. C., Clayton, Daniel J., Gunzburg, Menachem J., Price, John T., Pero, Stephanie C., Krag, David N., Wilce, Matthew C. J., Aguilar, Marie-Isabel, Perlmutter, Patrick, Wilce, Jacqueline A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 2011
• Subjects: breast cancer cells; cell uptake; co-localisation; Grb7 adapter protein; non-phosphorylated cyclic peptide; penetratin; peptide inhibitor; SH2 domain
• ISSN: 0006-3525; 1097-0282
• DOI: 10.1002/bip.21403

Grb7 is an adapter protein found to be overexpressed in several breast and other cancer cell types along with ErbB2. Grb7 is normally an interaction partner with focal adhesion kinase and in cancer cells also aberrantly interacts with ErbB2. It is thus implicated in the migratory and proliferative p...