Role of Catestatin in the Cardiovascular System and Metabolic Disorders

Catestatin is a multifunctional peptide that is involved in the regulation of the cardiovascular and immune systems as well as metabolic homeostatis. It mitigates detrimental, excessive activity of the sympathetic nervous system by inhibiting catecholamine secretion. Based on and studies, catestatin...

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Bibliographic Details
Published inFrontiers in cardiovascular medicine Vol. 9; p. 909480
Main Authors Zalewska, Ewa, Kmieć, Piotr, Sworczak, Krzysztof
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.05.2022
Subjects
Cardiovascular Medicine
cardiovascular system
catestatin
coronary artery disease
heart failure
hypertension
immunometabolism
coronary artery disease
heart failure
cardiovascular system
immunometabolism
metabolic disorder
catestatin
hypertension
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Summary:Catestatin is a multifunctional peptide that is involved in the regulation of the cardiovascular and immune systems as well as metabolic homeostatis. It mitigates detrimental, excessive activity of the sympathetic nervous system by inhibiting catecholamine secretion. Based on and studies, catestatin was shown to reduce adipose tissue, inhibit inflammatory response, prevent macrophage-driven atherosclerosis, and regulate cytokine production and release. Clinical studies indicate that catestatin may influence the processes leading to hypertension, affect the course of coronary artery diseases and heart failure. This review presents up-to-date research on catestatin with a particular emphasis on cardiovascular diseases based on a literature search.
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Reviewed by: Teresa Pasqua, University of Calabria, Italy; Geert Van Den Bogaart, University of Groningen, Netherlands
Edited by: Jian Shi, University of Leeds, United Kingdom
This article was submitted to Cardiovascular Metabolism, a section of the journal Frontiers in Cardiovascular Medicine
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2022.909480