Microwave-assisted synthesis of α-hydroxy ketone and α-diketone and pyrazine derivatives from α-halo and α,α′-dibromo ketone

A novel reaction of α-halo ketone (α-bromo and α-chloro ketone) with irradiation under microwave gave the corresponding α-hydroxyketone and pyrazine derivative in good yields. In the case of α,α′-dibromo ketone, α-diketone was obtained. This reaction affords a new, clean and convenient synthetic met...

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Bibliographic Details
Published inTetrahedron letters Vol. 47; no. 52; pp. 9359 - 9364
Main Authors Utsukihara, Takamitsu, Nakamura, Hiroaki, Watanabe, Masashige, Akira Horiuchi, C.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 25.12.2006
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
OXIDATION
PHOTOIRRADIATION
REDUCTION
SILYL ENOL ETHERS
CARBONYL-COMPOUNDS
IODINATION
STEP SYNTHESIS
TITANIUM
AZIDO KETONES
METAL PEROXIDE REACTIONS
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Summary:A novel reaction of α-halo ketone (α-bromo and α-chloro ketone) with irradiation under microwave gave the corresponding α-hydroxyketone and pyrazine derivative in good yields. In the case of α,α′-dibromo ketone, α-diketone was obtained. This reaction affords a new, clean and convenient synthetic method for α-hydroxyketone, α-diketone, α-chloro ketone and pyrazine derivative.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.10.087