Development of red-luminescent hybrids as contrast agents for cell imaging: A correlation among surface, luminescence, and biological properties
TTA (2-thenoyltrifluoroacetone), DBM (dibenzoylmethane), and EPHEN (5,6-Epoxy-5,6-dihydro- [1,10] phenanthroline) have generated europium complexes with excellent red emission properties. However, for bio applications, these complexes have been grafted on the surface of silica nanoparticles (SNP), b...
Saved in:
| Published in | Optical materials Vol. 139; p. 113759 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.05.2023
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | TTA (2-thenoyltrifluoroacetone), DBM (dibenzoylmethane), and EPHEN (5,6-Epoxy-5,6-dihydro- [1,10] phenanthroline) have generated europium complexes with excellent red emission properties. However, for bio applications, these complexes have been grafted on the surface of silica nanoparticles (SNP), by different approaches, due to their low water solubility. Here, we report how three approaches influence the surface, luminescent, and biological properties of 50 and 170 nm-SNP functionalized with carboxylic acid or phenanthroline ligands, useful to anchor TTA and DBM-Eu-complexes. TTA-hybrids exhibited better photophysical properties over the DBM ones, although intermolecular interactions between TTA and silica surface groups are likely to influence their properties. Aiming at such biological application, approach 3 resulted in the luminescent PHEN-hybrids with the highest values of intrinsic (φEuEu) and absolute quantum yields (φEuL), color purity of 100%, and high sensibilization efficiency (η). However, depending on the approach used, different surface charges were observed for the hybrids that directly impacted their cytotoxicity in Huh 7.5 cells. The larger the size of the nanoparticle or the more positive its surface charge is, the lower the toxicity of the hybrid. Even considering the presence of the protein corona effect, estimated in DMEM medium, the initial surface charge, observed in the buffer solution, plays an important role in the nanoparticle-cell interaction. Confocal microscopy images revealed that the hybrids were internalized by cells regardless of their size and surface charge, and their luminescence was also detectable, making them promising candidates for cell imaging applications as luminescent contrast agents. |
|---|---|
| AbstractList | TTA (2-thenoyltrifluoroacetone), DBM (dibenzoylmethane), and EPHEN (5,6-Epoxy-5,6-dihydro- [1,10] phenanthroline) have generated europium complexes with excellent red emission properties. However, for bio applications, these complexes have been grafted on the surface of silica nanoparticles (SNP), by different approaches, due to their low water solubility. Here, we report how three approaches influence the surface, luminescent, and biological properties of 50 and 170 nm-SNP functionalized with carboxylic acid or phenanthroline ligands, useful to anchor TTA and DBM-Eu-complexes. TTA-hybrids exhibited better photophysical properties over the DBM ones, although intermolecular interactions between TTA and silica surface groups are likely to influence their properties. Aiming at such biological application, approach 3 resulted in the luminescent PHEN-hybrids with the highest values of intrinsic (φEuEu) and absolute quantum yields (φEuL), color purity of 100%, and high sensibilization efficiency (η). However, depending on the approach used, different surface charges were observed for the hybrids that directly impacted their cytotoxicity in Huh 7.5 cells. The larger the size of the nanoparticle or the more positive its surface charge is, the lower the toxicity of the hybrid. Even considering the presence of the protein corona effect, estimated in DMEM medium, the initial surface charge, observed in the buffer solution, plays an important role in the nanoparticle-cell interaction. Confocal microscopy images revealed that the hybrids were internalized by cells regardless of their size and surface charge, and their luminescence was also detectable, making them promising candidates for cell imaging applications as luminescent contrast agents. |
| ArticleNumber | 113759 |
| Author | da Costa, Paulo Inácio Brito, Lorrane Davi Pires, Ana Maria Lima, Sergio Antonio Marques Santos, João Antonio Oliveira |
| Author_xml | – sequence: 1 givenname: João Antonio Oliveira surname: Santos fullname: Santos, João Antonio Oliveira organization: São Paulo State University (UNESP), Institute of Chemistry, Araraquara, 14800-900, São Paulo, Brazil – sequence: 2 givenname: Lorrane Davi surname: Brito fullname: Brito, Lorrane Davi organization: School of Pharmaceutical Sciences, São Paulo State University, Department of Clinical Analysis, Araraquara, 14800-903, São Paulo, Brazil – sequence: 3 givenname: Paulo Inácio surname: da Costa fullname: da Costa, Paulo Inácio organization: School of Pharmaceutical Sciences, São Paulo State University, Department of Clinical Analysis, Araraquara, 14800-903, São Paulo, Brazil – sequence: 4 givenname: Ana Maria surname: Pires fullname: Pires, Ana Maria organization: São Paulo State University (UNESP), Institute of Chemistry, Araraquara, 14800-900, São Paulo, Brazil – sequence: 5 givenname: Sergio Antonio Marques surname: Lima fullname: Lima, Sergio Antonio Marques email: sergio.lima@unesp.br organization: São Paulo State University (UNESP), Institute of Chemistry, Araraquara, 14800-900, São Paulo, Brazil |
| BookMark | eNp9kMtKxDAUhoMoOF7ewEUewI65tGnrQhjGKwhudB3S5KRmaJOSRMG38JFtGcGdq8O5_D_n_07QoQ8eELqgZE0JFVe7dZjyqPKaEcbXlPK6ag_QijY1Lyir2CFakZZVBS9FfYxOUtoRQlglxAp938InDGEawWccLI5giuFjdB6SXkbvX110JmGVsA4-R5UyVv28SdiGiDUMA3aj6p3vr_FmvokRBpVd8FiNwfc4fUSrNFziP9elU97gzoUh9E6rAU8xTBCzg3SGjqwaEpz_1lP0dn_3un0snl8enrab50JzInJhq7IUglrRgWlLZk1TW9J0Zc1MSdoWqq4xVLddQ7gSumaUV6Khtq45K5VhLT9F5d5Xx5BSBCunOAeJX5ISuVCVO7mnKheqck91lt3sZTD_9ukgyqTdEsm4CDpLE9z_Bj9j9odh |
| CitedBy_id | crossref_primary_10_3390_ma16175869 crossref_primary_10_1007_s00604_024_06446_6 |
| Cites_doi | 10.1063/1.1669896 10.1016/j.ccr.2014.10.013 10.1186/s11671-018-2728-6 10.1021/jp2075836 10.1186/s12989-021-00415-0 10.1016/j.nantod.2015.07.002 10.3390/ma13235494 10.1016/j.actbio.2013.04.026 10.3390/nano11113068 10.1039/a808692c 10.1016/j.jallcom.2020.155811 10.1088/1361-6528/ab5bc8 10.1515/pac-2014-1117 10.1021/acs.nanolett.0c02163 10.1039/C4TC01072H 10.1016/j.ccr.2015.02.015 10.1021/acsami.0c15514 10.1016/j.jlumin.2015.06.038 10.1016/j.optmat.2019.02.019 10.1021/acsabm.0c00814 10.1016/j.biomaterials.2004.07.050 10.1186/s11671-020-03344-7 10.1016/j.msec.2016.09.016 10.1021/jp048927z 10.1039/c3ta11463e 10.1039/C8NJ04560G 10.1039/C6DT03833F 10.1016/j.jnoncrysol.2020.120152 10.1016/0022-1759(83)90303-4 10.1002/smll.200901158 10.1002/jcc.23542 10.1155/2013/918369 10.1016/j.physb.2021.413470 10.1016/j.optmat.2022.113157 10.7150/ntno.65530 10.3390/molecules25092089 10.1038/srep02534 10.1039/D1MA01243F 10.1080/14686996.2019.1590731 10.1038/s41467-020-15889-3 10.1039/c3dt52238e 10.1007/s10971-021-05678-9 10.1016/j.msec.2017.02.028 |
| ContentType | Journal Article |
| Copyright | 2023 Elsevier B.V. |
| Copyright_xml | – notice: 2023 Elsevier B.V. |
| DBID | AAYXX CITATION |
| DOI | 10.1016/j.optmat.2023.113759 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Physics |
| EISSN | 1873-1252 |
| ExternalDocumentID | 10_1016_j_optmat_2023_113759 S0925346723003312 |
| GroupedDBID | --K --M .DC .~1 0R~ 123 1B1 1RT 1~. 1~5 29N 4.4 457 4G. 53G 5VS 7-5 71M 8P~ 9JN AABXZ AACTN AAEDT AAEDW AAEPC AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABFNM ABJNI ABMAC ABNEU ABTAH ABXDB ABXRA ABYKQ ACDAQ ACFVG ACGFS ACNNM ACRLP ADBBV ADEZE AEBSH AEKER AENEX AEZYN AFFNX AFKWA AFRZQ AFTJW AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AIVDX AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BBWZM BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMV HVGLF HZ~ IHE J1W KOM M24 M38 M41 MAGPM MO0 N9A NDZJH O-L O9- OAUVE OGIMB OZT P-8 P-9 P2P PC. Q38 R2- RIG RNS ROL RPZ SDF SDG SES SEW SMS SPC SPCBC SPD SPG SSM SSQ SSZ T5K UHS WUQ XPP ZMT ZY4 ~G- AAXKI AAYXX AFJKZ AKRWK CITATION |
| ID | FETCH-LOGICAL-c306t-f544661f6bed942fd87f08b472d4099e5b8d1c9b803a6c72135681f77324ad293 |
| IEDL.DBID | AIKHN |
| ISSN | 0925-3467 |
| IngestDate | Thu Sep 26 17:41:16 EDT 2024 Fri Feb 23 02:36:13 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Cytotoxicity Confocal microscopy Luminescent contrast agent Surface charge Cell imaging Europium complexes |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c306t-f544661f6bed942fd87f08b472d4099e5b8d1c9b803a6c72135681f77324ad293 |
| ParticipantIDs | crossref_primary_10_1016_j_optmat_2023_113759 elsevier_sciencedirect_doi_10_1016_j_optmat_2023_113759 |
| PublicationCentury | 2000 |
| PublicationDate | May 2023 2023-05-00 |
| PublicationDateYYYYMMDD | 2023-05-01 |
| PublicationDate_xml | – month: 05 year: 2023 text: May 2023 |
| PublicationDecade | 2020 |
| PublicationTitle | Optical materials |
| PublicationYear | 2023 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Aguiar, Costa, Espínola, Faustino, Moura, Brito, Paolini, Felinto, Teotonio (bib11) 2016; 170 (bib39) 2009 Foroozandeh, Aziz (bib49) 2018; 13 Yang, Li, Cao, Zeng, Cai (bib33) 2011; 115 Thommes, Kaneko, Neimark, Olivier, Rodriguez-Reinoso, Rouquerol, Sing (bib30) 2015; 87 Forest, Cottier, Pourchez (bib45) 2015; 10 (bib36) 2003 Silva, Botas, Brandão, Bastos, Oliveira, Debasu, Ferreira, Brites, Carlos (bib2) 2022; 626 Zhang, O’brien, Grimm (bib7) 2022; 6 Woo, Kim, Kim, Cheon, Yoon, Oh, Park (bib19) 2021; 11 Lechevallier, Jorge, Silveira, Ratel-Ramond, Neumeyer, Menu, Gressier, Marçal, Rocha, Martines, Magdeleine, Dexpert-Ghys, Verelst (bib37) 2013; 2013 Binnemans (bib34) 2015; 295 Carnall, Fields, Rajnak (bib12) 1968; 49 Mutti, Santos, Cavalcante, Gomes, Job, Pires, Lima (bib15) 2019; 90 Wang, Wu, Wu, Lei (bib3) 2022; 134 Gnoatto, de Oliveira, Arndt, Busatto, Ruiz, da Cunha, Moura, dos Santos (bib31) 2020; 542 . Mukherjee, Mullick, Reddy, Das, Raichur (bib23) 2020; 3 Felício, Nunes, Vaz, Botas, Ribeiro-Claro, Ferreira, Freire, Vaz, Carlos, Nunes, Nolasco (bib28) 2014; 2 Zhang, Zhao, Ma, Liu, Huang, Fu, Peng, Wang, Yang, Zhang, Ding, Yu, Zhu, Yan, Yang (bib42) 2022; 20 Yin Win, Feng (bib48) 2005; 26 Chinnathambi, Shirahata (bib8) 2019; 20 Trupp, Marchi, Barja (bib38) 2022; 102 Beeby, Clarkson, Dickins, Faulkner, Parker, Royle, De Sousa, Williams, Woods (bib35) 1999; 2 Reddy, Divya, Pavithran (bib4) 2013; 42 Ezquerro, López, Serrano, Alfaro-Arnedo, Lalinde, Larráyoz, Pichel, García-Martínez, Berenguer (bib18) 2022 Dutra, Bispo, Freire (bib26) 2014; 35 Inoue, Sakamoto, Suzuki, Nakai, Ando, Shiraki, Nakahara, Omura, Enomoto, Nakase, Sawada, Hashimoto (bib41) 2021; 18 Nolasco, Vaz, Freitas, Lima, André, Ferreira, Vaz, Ribeiro-Claro, Carlos (bib10) 2013; 1 Bünzli (bib13) 2015; 293–294 Socrates (bib27) 2001 Rasmussen, Pedersen, Marie (bib21) 2020; 11 Mutti, Santos, Cavalcante, Gomes, Job, Teixeira, Pires, Lima (bib14) 2019; 14 Forest, Pourchez (bib20) 2017; 70 Kurtz-Chalot, Villiers, Pourchez, Boudard, Martini, Marche, Cottier, Forest (bib22) 2017; 75 Rasband, W. ImageJ; Version 1.53e; Java 1.8.0_112 (64 Bit); National Institute of Health: Bethesda, MD, USA; Available online Soenen, Manshian, Doak, De Smedt, Braeckmans (bib50) 2013; 9 Yu, Li, Wang, Yu, Wang, Zhou, Li (bib44) 2020; 15 Gao, Yang, Zhang, Cao, Shen, Pang, Jiang (bib47) 2013; 3 Piñol, Zeler, Brites, Gu, Téllez, Carneiro Neto, Da Silva, Moreno-Loshuertos, Fernandez-Silva, Gallego, Martinez-Lostao, Martínez, Carlos, Millán (bib6) 2020; 20 Villanueva-Flores, Castro-Lugo, Ramírez, Palomares (bib40) 2020; 31 Cantarano, Yao, Matulionyte, Lifante, Benayas, Ortgies, Vetrone, Ibanez, Gérardin, Jaque, Dantelle (bib9) 2020; 12 Costa, Bispo-Jr, Lima, Pires (bib17) 2020; 843 Hasan, Iftikhar (bib24) 2019; 43 Monteiro (bib1) 2020; 25 Mosmann (bib25) 1983; 65 Ek, Iiskola, Niinistö, Vaittinen, Pakkanen, Root (bib32) 2004; 108 Santos, Mutti, Bispo-Jr, Pires, Lima (bib16) 2020; 13 Verma, Stellacci (bib43) 2010; 6 Augustine, Hasan, Primavera, Wilson, Thakor, Kevadiya (bib46) 2020; 25 George, Krishna, Reddy (bib5) 2016; 45 Wang (10.1016/j.optmat.2023.113759_bib3) 2022; 134 Yin Win (10.1016/j.optmat.2023.113759_bib48) 2005; 26 Thommes (10.1016/j.optmat.2023.113759_bib30) 2015; 87 Gao (10.1016/j.optmat.2023.113759_bib47) 2013; 3 Reddy (10.1016/j.optmat.2023.113759_bib4) 2013; 42 Yang (10.1016/j.optmat.2023.113759_bib33) 2011; 115 Ezquerro (10.1016/j.optmat.2023.113759_bib18) 2022 Chinnathambi (10.1016/j.optmat.2023.113759_bib8) 2019; 20 Inoue (10.1016/j.optmat.2023.113759_bib41) 2021; 18 Ek (10.1016/j.optmat.2023.113759_bib32) 2004; 108 Augustine (10.1016/j.optmat.2023.113759_bib46) 2020; 25 Mosmann (10.1016/j.optmat.2023.113759_bib25) 1983; 65 Felício (10.1016/j.optmat.2023.113759_bib28) 2014; 2 Soenen (10.1016/j.optmat.2023.113759_bib50) 2013; 9 Costa (10.1016/j.optmat.2023.113759_bib17) 2020; 843 Mukherjee (10.1016/j.optmat.2023.113759_bib23) 2020; 3 Zhang (10.1016/j.optmat.2023.113759_bib7) 2022; 6 Santos (10.1016/j.optmat.2023.113759_bib16) 2020; 13 Mutti (10.1016/j.optmat.2023.113759_bib15) 2019; 90 Mutti (10.1016/j.optmat.2023.113759_bib14) 2019; 14 Socrates (10.1016/j.optmat.2023.113759_bib27) 2001 Silva (10.1016/j.optmat.2023.113759_bib2) 2022; 626 George (10.1016/j.optmat.2023.113759_bib5) 2016; 45 Villanueva-Flores (10.1016/j.optmat.2023.113759_bib40) 2020; 31 Beeby (10.1016/j.optmat.2023.113759_bib35) 1999; 2 Kurtz-Chalot (10.1016/j.optmat.2023.113759_bib22) 2017; 75 10.1016/j.optmat.2023.113759_bib29 Piñol (10.1016/j.optmat.2023.113759_bib6) 2020; 20 Yu (10.1016/j.optmat.2023.113759_bib44) 2020; 15 Carnall (10.1016/j.optmat.2023.113759_bib12) 1968; 49 Gnoatto (10.1016/j.optmat.2023.113759_bib31) 2020; 542 Aguiar (10.1016/j.optmat.2023.113759_bib11) 2016; 170 Dutra (10.1016/j.optmat.2023.113759_bib26) 2014; 35 Rasmussen (10.1016/j.optmat.2023.113759_bib21) 2020; 11 Verma (10.1016/j.optmat.2023.113759_bib43) 2010; 6 Lechevallier (10.1016/j.optmat.2023.113759_bib37) 2013; 2013 Cantarano (10.1016/j.optmat.2023.113759_bib9) 2020; 12 Monteiro (10.1016/j.optmat.2023.113759_bib1) 2020; 25 Trupp (10.1016/j.optmat.2023.113759_bib38) 2022; 102 Zhang (10.1016/j.optmat.2023.113759_bib42) 2022; 20 Foroozandeh (10.1016/j.optmat.2023.113759_bib49) 2018; 13 Woo (10.1016/j.optmat.2023.113759_bib19) 2021; 11 Nolasco (10.1016/j.optmat.2023.113759_bib10) 2013; 1 Bünzli (10.1016/j.optmat.2023.113759_bib13) 2015; 293–294 (10.1016/j.optmat.2023.113759_bib36) 2003 Forest (10.1016/j.optmat.2023.113759_bib45) 2015; 10 Binnemans (10.1016/j.optmat.2023.113759_bib34) 2015; 295 Hasan (10.1016/j.optmat.2023.113759_bib24) 2019; 43 Forest (10.1016/j.optmat.2023.113759_bib20) 2017; 70 (10.1016/j.optmat.2023.113759_bib39) 2009 |
| References_xml | – volume: 25 year: 2020 ident: bib1 article-title: Recent advances in luminescence imaging of biological systems using lanthanide(III) luminescent complexes publication-title: Molecules contributor: fullname: Monteiro – year: 2009 ident: bib39 article-title: Biological Evaluation of Medical Devices - Part 5: Tests for in Vitro Cytotoxicity – start-page: 1 year: 2001 end-page: 347 ident: bib27 article-title: Infrared and Raman Characteristic Group Frequencies contributor: fullname: Socrates – volume: 75 start-page: 16 year: 2017 end-page: 24 ident: bib22 article-title: Impact of silica nanoparticle surface chemistry on protein corona formation and consequential interactions with biological cells publication-title: Mater. Sci. Eng. C contributor: fullname: Forest – volume: 108 start-page: 11454 year: 2004 end-page: 11463 ident: bib32 article-title: A 29 Si and 13 C CP/MAS NMR study on the surface species of gas-phase-deposited γ-aminopropylalkoxysilanes on heat-treated silica publication-title: J. Phys. Chem. B contributor: fullname: Root – year: 2003 ident: bib36 publication-title: Spectra Lux Software v.2.0, Ponto Quântico Nanodispositivos/RENAMI, 2003 – volume: 35 start-page: 772 year: 2014 end-page: 775 ident: bib26 article-title: LUMPAC lanthanide luminescence software: efficient and user friendly publication-title: J. Comput. Chem. contributor: fullname: Freire – volume: 11 start-page: 1 year: 2021 end-page: 15 ident: bib19 article-title: Charge-modulated synthesis of highly stable iron oxide nanoparticles for in vitro and in vivo toxicity evaluation publication-title: Nanomaterials contributor: fullname: Park – volume: 20 start-page: 1 year: 2022 end-page: 19 ident: bib42 article-title: Mechanistic study of silica nanoparticles on the size-dependent retinal toxicity in vitro and in vivo publication-title: J. Nanobiotechnol. contributor: fullname: Yang – volume: 13 start-page: 1 year: 2020 end-page: 17 ident: bib16 article-title: Red-emitting hybrid based on eu3+-dbm complex anchored on silica nanoparticles surface by carboxylic acid for biomarker application publication-title: Materials contributor: fullname: Lima – volume: 31 year: 2020 ident: bib40 article-title: Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices publication-title: Nanotechnology contributor: fullname: Palomares – volume: 2 start-page: 493 year: 1999 end-page: 503 ident: bib35 article-title: Non-radiative deactivation of the excited states of europium, terbium and ytterbium complexes by proximate energy-matched OH, NH and CH oscillators: an improved luminescence method for establishing solution hydration states publication-title: J. Chem. Soc. Perkin Trans. contributor: fullname: Woods – volume: 3 year: 2013 ident: bib47 article-title: Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization publication-title: Sci. Rep. contributor: fullname: Jiang – volume: 295 start-page: 1 year: 2015 end-page: 45 ident: bib34 article-title: Interpretation of europium(III) spectra publication-title: Coord. Chem. Rev. contributor: fullname: Binnemans – volume: 293–294 start-page: 19 year: 2015 end-page: 47 ident: bib13 article-title: On the design of highly luminescent lanthanide complexes publication-title: Coord. Chem. Rev. contributor: fullname: Bünzli – volume: 42 year: 2013 ident: bib4 article-title: Visible-light sensitized luminescent europium(iii)-β-diketonate complexes: bioprobes for cellular imaging publication-title: Dalton Trans. contributor: fullname: Pavithran – volume: 65 start-page: 55 year: 1983 end-page: 63 ident: bib25 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods contributor: fullname: Mosmann – start-page: 3582 year: 2022 end-page: 3592 ident: bib18 article-title: Highly emissive hybrid mesoporous organometallo-silica nanoparticles for bioimaging publication-title: Mater. Adv. contributor: fullname: Berenguer – volume: 1 start-page: 7339 year: 2013 end-page: 7350 ident: bib10 article-title: Engineering highly efficient Eu(iii)-based tri-ureasil hybrids toward luminescent solar concentrators publication-title: J. Mater. Chem. A. contributor: fullname: Carlos – volume: 87 start-page: 1051 year: 2015 end-page: 1069 ident: bib30 article-title: Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report) publication-title: Pure Appl. Chem. contributor: fullname: Sing – volume: 626 year: 2022 ident: bib2 article-title: 3D sub-cellular localization of upconverting nanoparticles through hyperspectral microscopy publication-title: Phys. B Condens. Matter contributor: fullname: Carlos – volume: 90 start-page: 57 year: 2019 end-page: 63 ident: bib15 article-title: Decorated silica particles with terbium complexes as luminescent biomarker for cell imaging publication-title: Opt. Mater. contributor: fullname: Lima – volume: 26 start-page: 2713 year: 2005 end-page: 2722 ident: bib48 article-title: Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs publication-title: Biomaterials contributor: fullname: Feng – volume: 2013 year: 2013 ident: bib37 article-title: Luminescence properties of mesoporous silica nanoparticles encapsulating different europium complexes: application for biolabelling publication-title: J. Nanomater. contributor: fullname: Verelst – volume: 10 start-page: 677 year: 2015 end-page: 680 ident: bib45 article-title: Electrostatic interactions favor the binding of positive nanoparticles on cells: a reductive theory publication-title: Nano Today contributor: fullname: Pourchez – volume: 134 year: 2022 ident: bib3 article-title: Yi shen, F. Li, LiGa5O8:Cr3+@PEG nanomaterials with near-infrared-persistent luminescence for bioimaging applications publication-title: Opt. Mater. contributor: fullname: Lei – volume: 70 start-page: 889 year: 2017 end-page: 896 ident: bib20 article-title: Preferential binding of positive nanoparticles on cell membranes is due to electrostatic interactions: a too simplistic explanation that does not take into account the nanoparticle protein corona publication-title: Mater. Sci. Eng. C contributor: fullname: Pourchez – volume: 115 start-page: 21056 year: 2011 end-page: 21062 ident: bib33 article-title: Origin of blue emission from silicon nanoparticles: direct transition and interface recombination publication-title: J. Phys. Chem. C contributor: fullname: Cai – volume: 843 year: 2020 ident: bib17 article-title: Multicolor-emitting luminescent Y2O3:RE3+@SiO2-[RE3+(β-diketone)3] core@shell hybrids featuring dual RE3+ activator centers publication-title: J. Alloys Compd. contributor: fullname: Pires – volume: 11 start-page: 1 year: 2020 end-page: 8 ident: bib21 article-title: Size and surface charge characterization of nanoparticles with a salt gradient publication-title: Nat. Commun. contributor: fullname: Marie – volume: 43 start-page: 2479 year: 2019 end-page: 2489 ident: bib24 article-title: Synthesis, crystal structure and photoluminescence studies of [Eu(dbm)3(impy)] and its polymer-based hybrid film publication-title: New J. Chem. contributor: fullname: Iftikhar – volume: 14 year: 2019 ident: bib14 article-title: Design of a red-emitter hybrid material for bioimaging: europium complexes grafted on silica particles publication-title: Mater. Today Chem. contributor: fullname: Lima – volume: 13 year: 2018 ident: bib49 article-title: Insight into cellular uptake and intracellular trafficking of nanoparticles publication-title: Nanoscale Res. Lett. contributor: fullname: Aziz – volume: 45 start-page: 18719 year: 2016 end-page: 18729 ident: bib5 article-title: A lysosome targetable luminescent bioprobe based on a europium β-diketonate complex for cellular imaging applications publication-title: Dalton Trans. contributor: fullname: Reddy – volume: 170 start-page: 538 year: 2016 end-page: 546 ident: bib11 article-title: Luminescent hybrid materials functionalized with lanthanide ethylenodiaminotetraacetate complexes containing β-diketonate as antenna ligands publication-title: J. Lumin. contributor: fullname: Teotonio – volume: 102 start-page: 63 year: 2022 end-page: 85 ident: bib38 article-title: Lanthanide–based luminescent hybrid silica materials prepared by sol-gel methodologies: a review publication-title: J. Sol. Gel Sci. Technol. contributor: fullname: Barja – volume: 9 start-page: 9183 year: 2013 end-page: 9193 ident: bib50 article-title: Fluorescent non-porous silica nanoparticles for long-term cell monitoring: cytotoxicity and particle functionality publication-title: Acta Biomater. contributor: fullname: Braeckmans – volume: 12 start-page: 51273 year: 2020 end-page: 51284 ident: bib9 article-title: Autofluorescence-free in vivo imaging using polymer-stabilized Nd3+-doped YAG nanocrystals publication-title: ACS Appl. Mater. Interfaces contributor: fullname: Dantelle – volume: 542 year: 2020 ident: bib31 article-title: Hybrid nanosilicas produced by the Stöber sol-gel process: in vitro evaluation in MRC-5 cells publication-title: J. Non-Cryst. Solids contributor: fullname: dos Santos – volume: 6 start-page: 12 year: 2010 end-page: 21 ident: bib43 article-title: Effect of surface properties on nanoparticle-cell interactions publication-title: Small contributor: fullname: Stellacci – volume: 6 start-page: 184 year: 2022 end-page: 194 ident: bib7 article-title: Biomedical applications of lanthanide nanomaterials, for imaging, sensing and therapy publication-title: Nanotheranostics contributor: fullname: Grimm – volume: 3 start-page: 7598 year: 2020 end-page: 7610 ident: bib23 article-title: Galactose functionalized mesoporous silica nanoparticles as delivery vehicle in the treatment of hepatitis C infection publication-title: ACS Appl. Bio Mater. contributor: fullname: Raichur – volume: 18 start-page: 1 year: 2021 end-page: 20 ident: bib41 article-title: Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages, Part publication-title: Fibre Toxicol contributor: fullname: Hashimoto – volume: 20 start-page: 337 year: 2019 end-page: 355 ident: bib8 article-title: Recent advances on fluorescent biomarkers of near-infrared quantum dots for in vitro and in vivo imaging publication-title: Sci. Technol. Adv. Mater. contributor: fullname: Shirahata – volume: 25 year: 2020 ident: bib46 article-title: Cellular uptake and retention of nanoparticles: insights on particle properties and interaction with cellular components publication-title: Mater. Today Commun. contributor: fullname: Kevadiya – volume: 2 start-page: 9701 year: 2014 end-page: 9711 ident: bib28 article-title: Modelling the luminescence of extended solids: an example of a highly luminescent MCM-41 impregnated with a Eu3+ β-diketonate complex publication-title: J. Mater. Chem. C contributor: fullname: Nolasco – volume: 49 start-page: 4450 year: 1968 end-page: 4455 ident: bib12 article-title: Electronic energy levels of the trivalent lanthanide aquo ions. IV. Eu 3+ publication-title: J. Chem. Phys. contributor: fullname: Rajnak – volume: 15 year: 2020 ident: bib44 article-title: Reactive oxygen species-related nanoparticle toxicity in the biomedical field publication-title: Nanoscale Res. Lett. contributor: fullname: Li – volume: 20 start-page: 6466 year: 2020 end-page: 6472 ident: bib6 article-title: Real-time intracellular temperature imaging using lanthanide-bearing polymeric micelles publication-title: Nano Lett. contributor: fullname: Millán – volume: 49 start-page: 4450 year: 1968 ident: 10.1016/j.optmat.2023.113759_bib12 article-title: Electronic energy levels of the trivalent lanthanide aquo ions. IV. Eu 3+ publication-title: J. Chem. Phys. doi: 10.1063/1.1669896 contributor: fullname: Carnall – volume: 293–294 start-page: 19 year: 2015 ident: 10.1016/j.optmat.2023.113759_bib13 article-title: On the design of highly luminescent lanthanide complexes publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2014.10.013 contributor: fullname: Bünzli – volume: 13 year: 2018 ident: 10.1016/j.optmat.2023.113759_bib49 article-title: Insight into cellular uptake and intracellular trafficking of nanoparticles publication-title: Nanoscale Res. Lett. doi: 10.1186/s11671-018-2728-6 contributor: fullname: Foroozandeh – volume: 115 start-page: 21056 year: 2011 ident: 10.1016/j.optmat.2023.113759_bib33 article-title: Origin of blue emission from silicon nanoparticles: direct transition and interface recombination publication-title: J. Phys. Chem. C doi: 10.1021/jp2075836 contributor: fullname: Yang – volume: 18 start-page: 1 year: 2021 ident: 10.1016/j.optmat.2023.113759_bib41 article-title: Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages, Part publication-title: Fibre Toxicol doi: 10.1186/s12989-021-00415-0 contributor: fullname: Inoue – start-page: 1 year: 2001 ident: 10.1016/j.optmat.2023.113759_bib27 contributor: fullname: Socrates – volume: 10 start-page: 677 year: 2015 ident: 10.1016/j.optmat.2023.113759_bib45 article-title: Electrostatic interactions favor the binding of positive nanoparticles on cells: a reductive theory publication-title: Nano Today doi: 10.1016/j.nantod.2015.07.002 contributor: fullname: Forest – volume: 13 start-page: 1 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib16 article-title: Red-emitting hybrid based on eu3+-dbm complex anchored on silica nanoparticles surface by carboxylic acid for biomarker application publication-title: Materials doi: 10.3390/ma13235494 contributor: fullname: Santos – volume: 9 start-page: 9183 year: 2013 ident: 10.1016/j.optmat.2023.113759_bib50 article-title: Fluorescent non-porous silica nanoparticles for long-term cell monitoring: cytotoxicity and particle functionality publication-title: Acta Biomater. doi: 10.1016/j.actbio.2013.04.026 contributor: fullname: Soenen – volume: 11 start-page: 1 year: 2021 ident: 10.1016/j.optmat.2023.113759_bib19 article-title: Charge-modulated synthesis of highly stable iron oxide nanoparticles for in vitro and in vivo toxicity evaluation publication-title: Nanomaterials doi: 10.3390/nano11113068 contributor: fullname: Woo – volume: 2 start-page: 493 issue: 2 year: 1999 ident: 10.1016/j.optmat.2023.113759_bib35 article-title: Non-radiative deactivation of the excited states of europium, terbium and ytterbium complexes by proximate energy-matched OH, NH and CH oscillators: an improved luminescence method for establishing solution hydration states publication-title: J. Chem. Soc. Perkin Trans. doi: 10.1039/a808692c contributor: fullname: Beeby – volume: 843 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib17 article-title: Multicolor-emitting luminescent Y2O3:RE3+@SiO2-[RE3+(β-diketone)3] core@shell hybrids featuring dual RE3+ activator centers publication-title: J. Alloys Compd. doi: 10.1016/j.jallcom.2020.155811 contributor: fullname: Costa – volume: 31 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib40 article-title: Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices publication-title: Nanotechnology doi: 10.1088/1361-6528/ab5bc8 contributor: fullname: Villanueva-Flores – volume: 87 start-page: 1051 year: 2015 ident: 10.1016/j.optmat.2023.113759_bib30 article-title: Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report) publication-title: Pure Appl. Chem. doi: 10.1515/pac-2014-1117 contributor: fullname: Thommes – volume: 20 start-page: 6466 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib6 article-title: Real-time intracellular temperature imaging using lanthanide-bearing polymeric micelles publication-title: Nano Lett. doi: 10.1021/acs.nanolett.0c02163 contributor: fullname: Piñol – ident: 10.1016/j.optmat.2023.113759_bib29 – volume: 2 start-page: 9701 year: 2014 ident: 10.1016/j.optmat.2023.113759_bib28 article-title: Modelling the luminescence of extended solids: an example of a highly luminescent MCM-41 impregnated with a Eu3+ β-diketonate complex publication-title: J. Mater. Chem. C doi: 10.1039/C4TC01072H contributor: fullname: Felício – volume: 295 start-page: 1 year: 2015 ident: 10.1016/j.optmat.2023.113759_bib34 article-title: Interpretation of europium(III) spectra publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2015.02.015 contributor: fullname: Binnemans – volume: 12 start-page: 51273 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib9 article-title: Autofluorescence-free in vivo imaging using polymer-stabilized Nd3+-doped YAG nanocrystals publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.0c15514 contributor: fullname: Cantarano – volume: 170 start-page: 538 year: 2016 ident: 10.1016/j.optmat.2023.113759_bib11 article-title: Luminescent hybrid materials functionalized with lanthanide ethylenodiaminotetraacetate complexes containing β-diketonate as antenna ligands publication-title: J. Lumin. doi: 10.1016/j.jlumin.2015.06.038 contributor: fullname: Aguiar – volume: 90 start-page: 57 year: 2019 ident: 10.1016/j.optmat.2023.113759_bib15 article-title: Decorated silica particles with terbium complexes as luminescent biomarker for cell imaging publication-title: Opt. Mater. doi: 10.1016/j.optmat.2019.02.019 contributor: fullname: Mutti – volume: 3 start-page: 7598 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib23 article-title: Galactose functionalized mesoporous silica nanoparticles as delivery vehicle in the treatment of hepatitis C infection publication-title: ACS Appl. Bio Mater. doi: 10.1021/acsabm.0c00814 contributor: fullname: Mukherjee – volume: 26 start-page: 2713 year: 2005 ident: 10.1016/j.optmat.2023.113759_bib48 article-title: Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs publication-title: Biomaterials doi: 10.1016/j.biomaterials.2004.07.050 contributor: fullname: Yin Win – volume: 15 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib44 article-title: Reactive oxygen species-related nanoparticle toxicity in the biomedical field publication-title: Nanoscale Res. Lett. doi: 10.1186/s11671-020-03344-7 contributor: fullname: Yu – volume: 25 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib46 article-title: Cellular uptake and retention of nanoparticles: insights on particle properties and interaction with cellular components publication-title: Mater. Today Commun. contributor: fullname: Augustine – year: 2003 ident: 10.1016/j.optmat.2023.113759_bib36 – volume: 70 start-page: 889 year: 2017 ident: 10.1016/j.optmat.2023.113759_bib20 article-title: Preferential binding of positive nanoparticles on cell membranes is due to electrostatic interactions: a too simplistic explanation that does not take into account the nanoparticle protein corona publication-title: Mater. Sci. Eng. C doi: 10.1016/j.msec.2016.09.016 contributor: fullname: Forest – volume: 108 start-page: 11454 year: 2004 ident: 10.1016/j.optmat.2023.113759_bib32 article-title: A 29 Si and 13 C CP/MAS NMR study on the surface species of gas-phase-deposited γ-aminopropylalkoxysilanes on heat-treated silica publication-title: J. Phys. Chem. B doi: 10.1021/jp048927z contributor: fullname: Ek – volume: 1 start-page: 7339 year: 2013 ident: 10.1016/j.optmat.2023.113759_bib10 article-title: Engineering highly efficient Eu(iii)-based tri-ureasil hybrids toward luminescent solar concentrators publication-title: J. Mater. Chem. A. doi: 10.1039/c3ta11463e contributor: fullname: Nolasco – volume: 43 start-page: 2479 year: 2019 ident: 10.1016/j.optmat.2023.113759_bib24 article-title: Synthesis, crystal structure and photoluminescence studies of [Eu(dbm)3(impy)] and its polymer-based hybrid film publication-title: New J. Chem. doi: 10.1039/C8NJ04560G contributor: fullname: Hasan – volume: 45 start-page: 18719 year: 2016 ident: 10.1016/j.optmat.2023.113759_bib5 article-title: A lysosome targetable luminescent bioprobe based on a europium β-diketonate complex for cellular imaging applications publication-title: Dalton Trans. doi: 10.1039/C6DT03833F contributor: fullname: George – volume: 542 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib31 article-title: Hybrid nanosilicas produced by the Stöber sol-gel process: in vitro evaluation in MRC-5 cells publication-title: J. Non-Cryst. Solids doi: 10.1016/j.jnoncrysol.2020.120152 contributor: fullname: Gnoatto – volume: 14 year: 2019 ident: 10.1016/j.optmat.2023.113759_bib14 article-title: Design of a red-emitter hybrid material for bioimaging: europium complexes grafted on silica particles publication-title: Mater. Today Chem. contributor: fullname: Mutti – volume: 65 start-page: 55 year: 1983 ident: 10.1016/j.optmat.2023.113759_bib25 article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays publication-title: J. Immunol. Methods doi: 10.1016/0022-1759(83)90303-4 contributor: fullname: Mosmann – volume: 6 start-page: 12 year: 2010 ident: 10.1016/j.optmat.2023.113759_bib43 article-title: Effect of surface properties on nanoparticle-cell interactions publication-title: Small doi: 10.1002/smll.200901158 contributor: fullname: Verma – volume: 35 start-page: 772 year: 2014 ident: 10.1016/j.optmat.2023.113759_bib26 article-title: LUMPAC lanthanide luminescence software: efficient and user friendly publication-title: J. Comput. Chem. doi: 10.1002/jcc.23542 contributor: fullname: Dutra – volume: 2013 year: 2013 ident: 10.1016/j.optmat.2023.113759_bib37 article-title: Luminescence properties of mesoporous silica nanoparticles encapsulating different europium complexes: application for biolabelling publication-title: J. Nanomater. doi: 10.1155/2013/918369 contributor: fullname: Lechevallier – volume: 626 year: 2022 ident: 10.1016/j.optmat.2023.113759_bib2 article-title: 3D sub-cellular localization of upconverting nanoparticles through hyperspectral microscopy publication-title: Phys. B Condens. Matter doi: 10.1016/j.physb.2021.413470 contributor: fullname: Silva – volume: 134 year: 2022 ident: 10.1016/j.optmat.2023.113759_bib3 article-title: Yi shen, F. Li, LiGa5O8:Cr3+@PEG nanomaterials with near-infrared-persistent luminescence for bioimaging applications publication-title: Opt. Mater. doi: 10.1016/j.optmat.2022.113157 contributor: fullname: Wang – volume: 6 start-page: 184 year: 2022 ident: 10.1016/j.optmat.2023.113759_bib7 article-title: Biomedical applications of lanthanide nanomaterials, for imaging, sensing and therapy publication-title: Nanotheranostics doi: 10.7150/ntno.65530 contributor: fullname: Zhang – volume: 25 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib1 article-title: Recent advances in luminescence imaging of biological systems using lanthanide(III) luminescent complexes publication-title: Molecules doi: 10.3390/molecules25092089 contributor: fullname: Monteiro – volume: 3 year: 2013 ident: 10.1016/j.optmat.2023.113759_bib47 article-title: Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization publication-title: Sci. Rep. doi: 10.1038/srep02534 contributor: fullname: Gao – start-page: 3582 year: 2022 ident: 10.1016/j.optmat.2023.113759_bib18 article-title: Highly emissive hybrid mesoporous organometallo-silica nanoparticles for bioimaging publication-title: Mater. Adv. doi: 10.1039/D1MA01243F contributor: fullname: Ezquerro – volume: 20 start-page: 1 year: 2022 ident: 10.1016/j.optmat.2023.113759_bib42 article-title: Mechanistic study of silica nanoparticles on the size-dependent retinal toxicity in vitro and in vivo publication-title: J. Nanobiotechnol. contributor: fullname: Zhang – volume: 20 start-page: 337 year: 2019 ident: 10.1016/j.optmat.2023.113759_bib8 article-title: Recent advances on fluorescent biomarkers of near-infrared quantum dots for in vitro and in vivo imaging publication-title: Sci. Technol. Adv. Mater. doi: 10.1080/14686996.2019.1590731 contributor: fullname: Chinnathambi – volume: 11 start-page: 1 year: 2020 ident: 10.1016/j.optmat.2023.113759_bib21 article-title: Size and surface charge characterization of nanoparticles with a salt gradient publication-title: Nat. Commun. doi: 10.1038/s41467-020-15889-3 contributor: fullname: Rasmussen – volume: 42 year: 2013 ident: 10.1016/j.optmat.2023.113759_bib4 article-title: Visible-light sensitized luminescent europium(iii)-β-diketonate complexes: bioprobes for cellular imaging publication-title: Dalton Trans. doi: 10.1039/c3dt52238e contributor: fullname: Reddy – volume: 102 start-page: 63 year: 2022 ident: 10.1016/j.optmat.2023.113759_bib38 article-title: Lanthanide–based luminescent hybrid silica materials prepared by sol-gel methodologies: a review publication-title: J. Sol. Gel Sci. Technol. doi: 10.1007/s10971-021-05678-9 contributor: fullname: Trupp – volume: 75 start-page: 16 year: 2017 ident: 10.1016/j.optmat.2023.113759_bib22 article-title: Impact of silica nanoparticle surface chemistry on protein corona formation and consequential interactions with biological cells publication-title: Mater. Sci. Eng. C doi: 10.1016/j.msec.2017.02.028 contributor: fullname: Kurtz-Chalot – year: 2009 ident: 10.1016/j.optmat.2023.113759_bib39 |
| SSID | ssj0002566 |
| Score | 2.4277356 |
| Snippet | TTA (2-thenoyltrifluoroacetone), DBM (dibenzoylmethane), and EPHEN (5,6-Epoxy-5,6-dihydro- [1,10] phenanthroline) have generated europium complexes with... |
| SourceID | crossref elsevier |
| SourceType | Aggregation Database Publisher |
| StartPage | 113759 |
| SubjectTerms | Cell imaging Confocal microscopy Cytotoxicity Europium complexes Luminescent contrast agent Surface charge |
| Title | Development of red-luminescent hybrids as contrast agents for cell imaging: A correlation among surface, luminescence, and biological properties |
| URI | https://dx.doi.org/10.1016/j.optmat.2023.113759 |
| Volume | 139 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEA7rLoIX8Ylv5uDRuG3Tp7dFlFXRiwreSp64grtLWw9e_A3-ZGf68AHiwWNKEspMMvMl-WaGsUPPyBj3s8ezRAtOKc5xS0U-F7HVcRaaUCsKFL6-icf34eVD9NBjp10sDNEqW9vf2PTaWrdfhq00h_PJZHjrZUEkcJ8jiPaEoErDA3RHQdpng9HF1fjm0yCjV6-fLLE_pwFdBF1N85rNK4SGx1RFnOqbJJS09DcP9c3rnK-w5RYuwqj5o1XWs9M1tljTNnW5zt6_cX5g5qCwhqO1ISo7sS7h8ZUCskqQJdScdFlWICmYqgQEq0C39jB5rgsVncAI-xRFS46DugoRlC-Fk9oewdes1JJTA036JtIxzOlGv6DUrBvs_vzs7nTM2xoLXONhoeIuogdd38XKmiwMnEkT56UqTAKDJ7_MRio1vs5U6gkZazwuCspY5pIEgZg0iBU2WX86m9otBkJaESmHAqeZAl_5oQqstQhqnNUy2Wa8k2s-b1Jp5B3H7Clv9JCTHvJGD9ss6YSf_1gSOVr7P0fu_HvkLluiVsNo3GP9qnix-4g6KnXAFo7f_IN2bX0AB6TZmw |
| link.rule.ids | 315,783,787,4509,24128,27936,27937,45597,45691 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JTsMwELUQCMEFsYqyzoEjpkmcpeFWIVBLoRdA4hZ5FUWirZJw4C_4ZGaysEiIA8ckthXNeMbP9psZxk48I2O0Z4-niRacUpyjSUU-F7HVcRqaUCsKFL4dx4OH8PoxelxgF20sDNEqG99f-_TKWzdvuo00u_PJpHvnpUEk0M4RRHtCUKXhJUQDKVrnUn84Gow_HTKu6tWVJbbn1KGNoKtoXrN5idDwjKqIU32ThJKW_rZCfVt1rtbZWgMXoV__0QZbsNNNtlzRNnWxxd6_cX5g5iC3hqO3ISo7sS7h6Y0CsgqQBVScdFmUICmYqgAEq0Cn9jB5qQoVnUMf2-R5Q46DqgoRFK-5k9qewteo9CSnBur0TaRjmNOJfk6pWbfZw9Xl_cWANzUWuMbNQsldRBe6vouVNWkYONNLnNdTYRIY3PmlNlI94-tU9TwhY43bRUEZy1ySIBCTBrHCDluczqZ2l4GQVkTKocBppMBXfqgCay2CGme1TDqMt3LN5nUqjazlmD1ntR4y0kNW66HDklb42Y8pkaG3_7Pn3r97HrOVwf3tTXYzHI_22Sp9qdmNB2yxzF_tISKQUh01M-wDTfzbjw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Development+of+red-luminescent+hybrids+as+contrast+agents+for+cell+imaging%3A+A+correlation+among+surface%2C+luminescence%2C+and+biological+properties&rft.jtitle=Optical+materials&rft.au=Santos%2C+Jo%C3%A3o+Antonio+Oliveira&rft.au=Brito%2C+Lorrane+Davi&rft.au=da+Costa%2C+Paulo+In%C3%A1cio&rft.au=Pires%2C+Ana+Maria&rft.date=2023-05-01&rft.pub=Elsevier+B.V&rft.issn=0925-3467&rft.eissn=1873-1252&rft.volume=139&rft_id=info:doi/10.1016%2Fj.optmat.2023.113759&rft.externalDocID=S0925346723003312 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0925-3467&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0925-3467&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0925-3467&client=summon |