A cascaded enzyme system based on the catalase-like activity of Ti3C2Tx MXene nanosheets for the efficient combination cancer therapy
Catalytic therapy with enzymes and nanozymes is a promising approach to cancer treatment. However, it often proves inadequate when used as a standalone treatment. This work presents the catalase (CAT)-like activity of Ti3C2Tx MXene, a kind of two-dimensional (2D) material with photothermal capabilit...
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| Published in | Nano today Vol. 54; p. 102059 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ltd
01.02.2024
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| Subjects | |
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| Abstract | Catalytic therapy with enzymes and nanozymes is a promising approach to cancer treatment. However, it often proves inadequate when used as a standalone treatment. This work presents the catalase (CAT)-like activity of Ti3C2Tx MXene, a kind of two-dimensional (2D) material with photothermal capability. Ti3C2Tx nanosheets were then used to load glucose oxidase (GOx) and the anticancer drug doxorubicin hydrochloride (DOX), and modified with polyethylene glycol (PEG) to obtain an enzyme cascade system, named Ti3C2Tx-GOx/DOX-PEG, for anticancer purposes. Ti3C2Tx-GOx/DOX-PEG exhibited a photothermal conversion efficiency of ∼28.7% at 808 nm, enabling its use for near-infrared light-based photothermal therapy (PTT). In addition, Ti3C2Tx could decompose H2O2 to O2 in cancer cells, thereby enhancing starvation therapy by sensitizing GOx. Furthermore, alleviation of hypoxia could sensitize the chemotherapy of DOX. The decomposition of glucose by GOx could also generate H2O2 for the production of O2 by Ti3C2Tx. Ultimately, the cycling of the enzyme cascade reaction could alleviate tumor hypoxia and enable enhanced chemo/starvation/photothermal combination therapy. The CAT-like behavior of Ti3C2Tx as well as various enzymatic reactions catalyzed by Ti3C2Tx-GOx/DOX-PEG were systematically investigated by intra- and extracellular experiments. Results from both in vitro and in vivo studies demonstrated the effective anticancer capability of Ti3C2Tx-GOx/DOX-PEG. This enzyme cascade system has the potential to enhance material utilization and reduce side effects, thus opening up new opportunities for designing efficient and safe anticancer systems.
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•The CAT-like activity of Ti3C2Tx MXene is reported and well-studied.•The enzyme cascade system Ti3C2Tx-GOx/DOX-PEG is prepared with Ti3C2Tx, GOx, and DOX.•The cycling of the enzyme cascade reaction can enable enhanced combination therapy.•Ti3C2Tx-GOx/DOX-PEG shows a good anticancer effect with low side effects. |
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| AbstractList | Catalytic therapy with enzymes and nanozymes is a promising approach to cancer treatment. However, it often proves inadequate when used as a standalone treatment. This work presents the catalase (CAT)-like activity of Ti3C2Tx MXene, a kind of two-dimensional (2D) material with photothermal capability. Ti3C2Tx nanosheets were then used to load glucose oxidase (GOx) and the anticancer drug doxorubicin hydrochloride (DOX), and modified with polyethylene glycol (PEG) to obtain an enzyme cascade system, named Ti3C2Tx-GOx/DOX-PEG, for anticancer purposes. Ti3C2Tx-GOx/DOX-PEG exhibited a photothermal conversion efficiency of ∼28.7% at 808 nm, enabling its use for near-infrared light-based photothermal therapy (PTT). In addition, Ti3C2Tx could decompose H2O2 to O2 in cancer cells, thereby enhancing starvation therapy by sensitizing GOx. Furthermore, alleviation of hypoxia could sensitize the chemotherapy of DOX. The decomposition of glucose by GOx could also generate H2O2 for the production of O2 by Ti3C2Tx. Ultimately, the cycling of the enzyme cascade reaction could alleviate tumor hypoxia and enable enhanced chemo/starvation/photothermal combination therapy. The CAT-like behavior of Ti3C2Tx as well as various enzymatic reactions catalyzed by Ti3C2Tx-GOx/DOX-PEG were systematically investigated by intra- and extracellular experiments. Results from both in vitro and in vivo studies demonstrated the effective anticancer capability of Ti3C2Tx-GOx/DOX-PEG. This enzyme cascade system has the potential to enhance material utilization and reduce side effects, thus opening up new opportunities for designing efficient and safe anticancer systems.
[Display omitted]
•The CAT-like activity of Ti3C2Tx MXene is reported and well-studied.•The enzyme cascade system Ti3C2Tx-GOx/DOX-PEG is prepared with Ti3C2Tx, GOx, and DOX.•The cycling of the enzyme cascade reaction can enable enhanced combination therapy.•Ti3C2Tx-GOx/DOX-PEG shows a good anticancer effect with low side effects. |
| ArticleNumber | 102059 |
| Author | Li, Cao Qiao, Qianqian Guo, Yuhao Chen, Jiahao Kuang, Ying Ji, Tianjiao Wang, Jinyu Long, Kai Xu, Ziqiang Li, Linwei |
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| Keywords | Combination cancer therapy Enzyme cascade system Nanozyme Catalase-like activity MXene |
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| SubjectTerms | Catalase-like activity Combination cancer therapy Enzyme cascade system MXene Nanozyme |
| Title | A cascaded enzyme system based on the catalase-like activity of Ti3C2Tx MXene nanosheets for the efficient combination cancer therapy |
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