Antioxidant properties of gold nanozyme: A review

• Published in: Journal of molecular liquids Vol. 297; p. 112004
• Main Authors: Sharifi, Majid, Faryabi, Kousar, Talaei, Amir Jouya, Shekha, Mudhir Sabir, Ale-Ebrahim, Mahsa, Salihi, Abbas, Nanakali, Nadir Mustafa Qadir, Aziz, Falah Mohammad, Rasti, Behnam, Hasan, Anwarul, Falahati, Mojtaba
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2020
• Subjects: Au nanozymes; Catalase-like activity; Enzymatic mimic; Oxidase-like activity; Peroxidase-like activity; Physicochemical properties; Superoxide dismutase-like activity; Glucose oxidase; Enzymatic mimic; Reactive oxygen species; Horseradish peroxidase; Superoxide dismutase; Iron; Cerium oxide; Gold nanocluster; Limit of detection; Catalase; Surface-enhanced Raman scattering; Platinum; Oxidase-like activity; Peroxidase-like activity; Gold nanoparticle; Palladium; Silver; Au nanozymes; Superoxide dismutase-like activity; Graphene oxide; Surface plasmon resonance; Single-wall carbon nanotubes; Copper oxide; Physicochemical properties; Catalase-like activity
• DOI: 10.1016/j.molliq.2019.112004
• ISSN: 0167-7322

AuNPs with enzyme-like features have received strong attention in different areas, although limited data is available in literature on their biological/industrial functions. NPs especially Au counterparts have been shown to functionally mimic the activity of antioxidant enzyme. Indeed, due to low cytotoxicity and SPR characteristics of AuNPs, there are a great number of reports in which Au nanozymes yield promising responses in biomedical applications. In this review, we aim to overview the enzymatic activity of Au nanozymes along with their regulatory and controlling mechanisms. We have reviewed the effect of various factors such as dimension, morphology, functionalization and presence of hybrid materials on the catalytic activity of Au nanozymes as well as a detail survey on the oxidase, peroxidase, SOD, and CAT-like activities of Au nanozyme. Finally, the significance of Au nanozymes in mitigating oxidative stress followed by conclusion and challenges were reported. Based on this paper, we envision that Au nanozymes can be used as a promising material to prevent oxidative stress-stimulated disorders. •Antioxidant-like activities of Au nanozymes.•Oxidase-like activity of Au nanozymes.•Peroxidase-like activity of Au nanozymes.•Superoxide dismutase-like activity of Au nanozymes.•Catalase-like activity of Au nanozymes.