Coagulation, Fibrinolysis and Inhibitors in Failing Filters during Continuous Venovenous Hemofiltration in Critically Ill Patients with Acute Kidney Injury: Effect of Anticoagulation Modalities

• Published in: Blood purification Vol. 39; no. 4; pp. 297 - 305
• Main Authors: Schilder, Louise, Nurmohamed, S. Azam, ter Wee, Pieter M., Paauw, Nanne J., Girbes, Armand R.J., Beishuizen, Albertus, Beelen, Robert H.J., Groeneveld, A.B. Johan
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.01.2015
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - etiology; Acute Kidney Injury - mortality; Acute Kidney Injury - therapy; Adult; Aged; Aged, 80 and over; Anticoagulants - therapeutic use; Blood Coagulation; Blood Coagulation Factor Inhibitors; Citric Acid - therapeutic use; Critical Illness; Female; Fibrinolysis; Hemofiltration - adverse effects; Heparin - therapeutic use; Humans; Male; Micropore Filters - adverse effects; Middle Aged; Original Paper; Sepsis - etiology; Sepsis - mortality; Time Factors; Young Adult; Platelet activation; Filter survival; Patient outcome; Citrate versus heparin; Acute kidney injury; Anticoagulation; Continuous renal replacement therapy

Introduction: The mechanisms of early filter failure and clotting with different anticoagulation modalities during continuous venovenous hemofiltration (CVVH) are largely unknown. Methods: Citrate, heparin and no anticoagulation were compared. Blood was drawn pre- and post filter up to 720 min. Conc...