Mussel-inspired synthesis of magnetic N-Halamine nanoparticles for antibacterial recycling

• Published in: Colloid and interface science communications Vol. 39; p. 100320
• Main Authors: Chai, Danxia, Liu, Wenxin, Hao, Xiufeng, Wang, Heyuan, Wang, Haixiao, Hao, Yujiao, Gao, Yue, Qu, Huihui, Wang, Lifang, Dong, Alideertu, Gao, Ge
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2020
• Subjects: Antibacterial use; Dopamine; Magnetic nanoparticles; Mussel-inspired; N-halamine coating; Dopamine; Antibacterial use; N-halamine coating; Mussel-inspired; Magnetic nanoparticles
• ISSN: 2215-0382; 2215-0382
• DOI: 10.1016/j.colcom.2020.100320

Antibacterial N-halamine coatings are successful in avoiding and eliminating bacterial infections caused by bacterial contamination and biofilms on the surfaces. However, the N-halamine coatings remain a long-standing challenge faced by our healthcare system. Herein we reported a new mussel-inspired surface modification strategy to achieve N-halamine copolymer coatings with adhesive effects. The phenolic hydroxyl groups from N-halamine copolymers are used for ligand exchange with oleic acid on the magnetic Fe3O4 nanoparticles for binding the N-halamine copolymer onto the surface of the nanoparticles. The as-synthesized N-halamine coatings endow the magnetic Fe3O4 nanoparticles antibacterial activity toward both Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). Since the super-paramagnetism of Fe3O4 in core, the N-halamine coatings are separable magnetically and remain high inactivating efficiency toward bacteria even after five cycles. We believe that, with the advantage of mussel-inspired strategy, the N-halamine coatings should have great potential for use in antibacterial and biomedical fields. [Display omitted] •A mussel-inspired synthesis for achieving N-halamine coatings is proposed.•The coating mechanism relies on the ligand exchange.•N-Halamine coatings endow good antibacterial activity and renewability.