Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents

• Published in: Oncogene Vol. 38; no. 1; pp. 47 - 59
• Main Authors: Stratikopoulos, Elias E., Kiess, Nicole, Szabolcs, Matthias, Pegno, Sarah, Kakit, Cheung, Wu, Xuewei, Poulikakos, Poulikos I., Cheung, Pamela, Schmidt, Hank, Parsons, Ramon
• Format: Journal Article
• Language: English
• Published: 03.08.2018

Estrogen dependence is major driver of ER + breast cancer, which is associated with PI3K mutation. PI3K inhibition (PI3Ki) can restore dependence on ER signaling for some hormone therapy-resistant ER + breast cancers, but is ineffective in others. Here we show that short-term supplementation with es...