Long-term effects of Semliki Forest virus infection in the mouse central nervous system

• Published in: Neuropathology and applied neurobiology Vol. 23; no. 3; pp. 235 - 241
• Main Authors: DONNELLY, S. M, SHEAHAN, B. J, ATKINS, G. J
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Science 01.06.1997
• Subjects: Alphavirus Infections - pathology; Alphavirus Infections - physiopathology; Animals; Biological and medical sciences; Central Nervous System - virology; Cytokines - genetics; Human viral diseases; Infectious diseases; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Polymerase Chain Reaction; RNA, Viral - analysis; Semliki forest virus - genetics; Semliki forest virus - isolation & purification; Spinal Cord - pathology; Time Factors; Transcription, Genetic; Viral diseases; Viral diseases of the nervous system; Semliki forest virus; Encephalitis; Animal model; Nervous system diseases; Multiple sclerosis; Pathogenesis; Rodentia; Togaviridae; Cerebral disorder; Inflammatory disease; Infection; Virus; Pathology; Vertebrata; Mammalia; Mouse; Animal; Viral disease; Arbovirus disease; Central nervous system disease; Alphavirus; Semliki forest disease

Semliki Forest virus (SFV) infection of mice is used as a model to study pathogenic processes occurring in viral encephalitis and demyelinating disease. In this study, the long-term effects of infection by the avirulent M9 mutant of SPV on the central nervous system (CNS) of BALB/c and SJL mice were...