Chemical Composition of Artemisia argyi Extract (RW0117) and Protective Effects against Gastric Lesions in vivo

• Published in: Natural product sciences Vol. 26; no. 4; pp. 268 - 278
• Main Authors: Lee, Jin-Woo, Lee, Il Kyun, Park, Se-Hoon, Chang, Min Jegal, Choi, Keun Young, Jung, Hye Young, Choi, Jung A, Lee, Chan-Kyu, Kim, Ho Kyong, Lee, Jung Suk
• Format: Journal Article
• Language: English
• Published: 한국생약학회 01.01.2020
• Subjects: 약학; Artemisia argyi; RW0117; Flavonoids; Caffeoylquinic acids; Chemical profile; Gastric ulcer
• ISSN: 1226-3907; 2288-9027
• DOI: 10.20307/nps.2020.26.4.268

In this study, we investigated the chemical profile and effects of RW0117 (Artemisia argyi 65.5% ethanol extract) on gastric lesions in rats. We optimized and validated a method to obtain the chemical profile of RW0117. We then investigated the antioxidant and anti-inflammatory effects in vitro, and the protective effects on gastric lesions in vivo. The IC50 of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging considering the antioxidant effects of RW0117 was 166.55 μg/mL, and the IC50 of nitric oxide scavenging considering the anti-inflammatory effects was 41.16 μg/mL. Oral administration of RW0117 at lower concentrations (25, 50, 100 mg/kg) had similar or greater effects than the daily intake conversion concentration (115 mg/kg) of a health functional food (Avexol®) in the acetic acid-induced ulcer and the ethanol-induced gastric injury rat models. In addition, oral administration of RW0117 increased the expression of prostaglandin E2, which enhances the protective effect in the gastric mucosa in the ethanol-induced gastric injury rat model. These results suggest that RW0117 may have potential therapeutic uses in the protection of the gastric mucosa. KCI Citation Count: 0