Cell-based screening test for idiopathic scoliosis using cellular dielectric spectroscopy

• Published in: Spine (Philadelphia, Pa. 1976) Vol. 35; no. 13; p. E601
• Main Authors: Akoume, Marie-Yvonne, Azeddine, Bouziane, Turgeon, Isabelle, Franco, Anita, Labelle, Hubert, Poitras, Benoît, Rivard, Charles-Hilaire, Grimard, Guy, Ouellet, Jean, Parent, Stefan, Moreau, Alain
• Format: Journal Article
• Language: English
• Published: United States 01.06.2010
• Subjects: Adolescent; Cells, Cultured; Child; Child, Preschool; Cyclic AMP - metabolism; Early Diagnosis; Electrochemical Techniques - methods; Female; Humans; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - metabolism; Male; Mass Screening - methods; Osteoblasts - cytology; Osteoblasts - metabolism; Prognosis; Scoliosis - blood; Scoliosis - diagnosis; Sensitivity and Specificity; Spectrum Analysis - methods; Young Adult

A cell-based assay was developed to identify asymptomatic children at risk of developing idiopathic scoliosis (IS) and to stratify IS patients at an earlier stage in order to better predict their clinical outcome. Clinical validation of this assay was performed by testing IS patients at different st...