Unmethylated state of 5′ upstream CpG islands may be necessary but not sufficient for the testis-enriched expression of ZNF230/Znf230

• Published in: Genes & genomics Vol. 36; no. 2; pp. 163 - 169
• Main Authors: Liu, Yunqiang, Tao, Dachang, Yang, Yuan, Ma, Yongxin, Zhang, Sizhong
• Format: Journal Article
• Language: English
• Published: Seoul The Genetics Society of Korea 01.04.2014; 한국유전학회
• Subjects: Animal Genetics and Genomics; Biomedical and Life Sciences; Human Genetics; Life Sciences; Microbial Genetics and Genomics; Plant Genetics and Genomics; Research Article; 생물학; DNA methylation; Testis-enriched gene; Sp1; Genomic imprinting

The testis-enriched genes ZNF230/Znf230 are located on human chromosome 11p15/mouse chromosome 7 near conserved imprinting control regions. Typical CpG islands (CGIs) extend from the promoter to the first exon in each of these genes. To investigate the correlation between the methylation status of t...