Graphene biosensor as affinity biosensors for biorecognition between Guanine riboswitch and ligand

• Published in: Applied surface science Vol. 503; p. 144303
• Main Authors: Tian, Meng, Li, Zhenhua, Song, Ruihong, Li, Yingxian, Guo, Chengang, Sha, Yujie, Cui, Wanling, Xu, Shicai, Hu, Guodong, Wang, Jihua
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.02.2020
• Subjects: Electric-neutral molecule detection; Graphene field effect transistor biosensors; Guanine riboswitch; Ligand molecules; Electric-neutral molecule detection; Ligand molecules; Guanine riboswitch; Graphene field effect transistor biosensors

•G-FET biosensor was developed to detect the binding interactions between GR and ligand molecules.•Mechanisms for electric-neutral molecule sensing was revealed by molecular dynamics simulation.•Equilibrium dissociation constants KD and binding free energy ΔG of GR and ligand molecules were obtained...