Oligochitosan glycosylation of casein by TGase: Protective effect and mechanism on alcohol-induced intestinal injury in C57BL/6 mice
Glycosylated protein by transglutaminase-type could alter the structures and functional properties of proteins. However, the beneficial effects of glycosylated proteins against alcohol-induced intestinal injury remain unclear. Herein, the protective role and mechanism of glycosylated casein ameliora...
Saved in:
| Published in | Journal of functional foods Vol. 111; p. 105892 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier
01.12.2023
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Glycosylated protein by transglutaminase-type could alter the structures and functional properties of proteins. However, the beneficial effects of glycosylated proteins against alcohol-induced intestinal injury remain unclear. Herein, the protective role and mechanism of glycosylated casein ameliorating alcohol-induced intestinal injury were assessed in vivo. The results showed that glycosylated casein and casein significantly relieved alcohol-induced oxidative stress and inflammatory responses in a concentration-dependent manner. The interventions of glycosylated casein and casein decreased serum parameters, improved the activities of antioxidant enzymes, reduced levels of inflammatory cytokines, and alleviated histopathological impairment in intestine tissues. Glycosylated casein and casein treatment downregulated protein expressions of TLR4, NF-κB p65, IKB-α, and MyD88 in mice, which activated the TLR4/NF-κB signaling pathway as a protective mechanism. More importantly, glycosylated caseinate showed a better effect against alcohol-induced intestinal injury than casein, suggesting that transglutaminase-mediated glycosylation of proteins is a useful technique to enforce protein biofunctions in the intestine. |
|---|---|
| AbstractList | Glycosylated protein by transglutaminase-type could alter the structures and functional properties of proteins. However, the beneficial effects of glycosylated proteins against alcohol-induced intestinal injury remain unclear. Herein, the protective role and mechanism of glycosylated casein ameliorating alcohol-induced intestinal injury were assessed in vivo. The results showed that glycosylated casein and casein significantly relieved alcohol-induced oxidative stress and inflammatory responses in a concentration-dependent manner. The interventions of glycosylated casein and casein decreased serum parameters, improved the activities of antioxidant enzymes, reduced levels of inflammatory cytokines, and alleviated histopathological impairment in intestine tissues. Glycosylated casein and casein treatment downregulated protein expressions of TLR4, NF-κB p65, IKB-α, and MyD88 in mice, which activated the TLR4/NF-κB signaling pathway as a protective mechanism. More importantly, glycosylated caseinate showed a better effect against alcohol-induced intestinal injury than casein, suggesting that transglutaminase-mediated glycosylation of proteins is a useful technique to enforce protein biofunctions in the intestine. |
| ArticleNumber | 105892 |
| Author | Shi, Jia Yue, Yingying Wang, Yu Wang, Huimin Jiang, Yujun |
| Author_xml | – sequence: 1 givenname: Yu surname: Wang fullname: Wang, Yu – sequence: 2 givenname: Yingying surname: Yue fullname: Yue, Yingying – sequence: 3 givenname: Huimin surname: Wang fullname: Wang, Huimin – sequence: 4 givenname: Yujun surname: Jiang fullname: Jiang, Yujun – sequence: 5 givenname: Jia orcidid: 0000-0002-4765-6512 surname: Shi fullname: Shi, Jia |
| BookMark | eNo9kctu2zAQRblIgMZJP6A7_oAcPmSa6q4x0jSAAWfhrInRcGhTkMlCVAJo3w-PHBdZ3TsXmLM5C3aVciLGfkixlEKa-27ZhbBUQun5XtlGXbEbuV6Zqja1-cYWpXRCGCO1uGH_dn08ZDzGMRdI_NBPmMvUwxhz4jlwhEIx8Xbi-6e5_uQvQx4Jx_hOnEKYG4fk-YnwCCmWE5_foMd8zH0Vk39D8jymkcoYE_Rz7d6GaQ6-Wa0ftveGnyLSHbsO0Bf6_j9v2evvx_3mT7XdPT1vfm0r1MKMlVEqKLLGt-sVNUE2XnuthSW0tqVaIQjQIcg1BWiFJNTeg9aEJHWDQPqWPV-4PkPn_g7xBMPkMkT3OeTh4GAYI_bkDJpaGmwa0L4Oqm5ba9FKpEYBBetnlrywcMilDBS-eFK4swbXuVmDO2twFw36A0O0gyc |
| Cites_doi | 10.1016/j.foodchem.2021.129302 10.1016/j.tifs.2022.10.003 10.1039/C8FO01785A 10.1016/j.foodres.2022.110945 10.1016/j.foodchem.2019.04.004 10.3390/cells12050822 10.1016/j.intimp.2020.107272 10.1016/j.foodhyd.2023.108462 10.1016/j.carbpol.2021.118816 10.1016/j.foodres.2022.111283 10.1039/C8FO00909K 10.1016/j.fbio.2022.102224 10.1016/j.lfs.2023.121818 10.1016/j.biopha.2023.114719 10.1146/annurev-immunol-070119-115104 10.1016/j.fct.2021.112240 10.1021/acs.jafc.1c02858 10.1038/s41575-018-0099-1 10.1016/j.fct.2023.113851 10.1039/D1FO01693H 10.1016/j.jgr.2023.02.003 10.1016/j.foodchem.2015.11.096 10.1111/1541-4337.13138 10.1016/j.mpmed.2023.02.005 10.1016/j.ijbiomac.2022.04.067 10.1016/j.foodres.2022.111259 10.3390/foods10112688 10.1016/j.fct.2023.113652 10.1080/10408398.2017.1406333 10.1016/j.lwt.2021.111550 10.1016/j.biomaterials.2023.122049 10.1016/j.alcohol.2015.02.007 |
| ContentType | Journal Article |
| DBID | AAYXX CITATION DOA |
| DOI | 10.1016/j.jff.2023.105892 |
| DatabaseName | CrossRef Directory of Open Access Journals |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| ExternalDocumentID | oai_doaj_org_article_6c6416c99a3d4f24bb88c81ce92aef8d 10_1016_j_jff_2023_105892 |
| GroupedDBID | --K --M .~1 0R~ 0SF 1B1 1~. 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ AACTN AAEDT AAEDW AAFTH AAHBH AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATLK AAXKI AAXUO AAYXX ABFNM ABGRD ABGSF ABJNI ABMAC ABXDB ACDAQ ACGFS ACNNM ACRLP ADBBV ADECG ADEZE ADMUD ADQTV ADUVX ADVLN AEBSH AEHWI AEKER AENEX AEQOU AEXQZ AFJKZ AFKWA AFTJW AFXIZ AFZHZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJOXV AJSZI AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CITATION EBS EFJIC EJD EP2 EP3 F5P FDB FEDTE FIRID FLBIZ FNPLU FYGXN GBLVA GROUPED_DOAJ HVGLF HZ~ J1W KOM M41 MO0 N9A NCXOZ O-L O9- OAUVE OK1 OZT P-8 P-9 P2P PC. Q38 RIG ROL SDF SES SPC SSA SSK SSU SSZ T5K ~G- |
| ID | FETCH-LOGICAL-c306t-622f2e86db75e9f19d3d3308ec88be42ca0a3ff17efab01ec3dda33ece139cae3 |
| IEDL.DBID | DOA |
| ISSN | 1756-4646 |
| IngestDate | Tue Oct 22 15:11:28 EDT 2024 Thu Sep 26 18:35:21 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c306t-622f2e86db75e9f19d3d3308ec88be42ca0a3ff17efab01ec3dda33ece139cae3 |
| ORCID | 0000-0002-4765-6512 |
| OpenAccessLink | https://doaj.org/article/6c6416c99a3d4f24bb88c81ce92aef8d |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_6c6416c99a3d4f24bb88c81ce92aef8d crossref_primary_10_1016_j_jff_2023_105892 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-12-00 2023-12-01 |
| PublicationDateYYYYMMDD | 2023-12-01 |
| PublicationDate_xml | – month: 12 year: 2023 text: 2023-12-00 |
| PublicationDecade | 2020 |
| PublicationTitle | Journal of functional foods |
| PublicationYear | 2023 |
| Publisher | Elsevier |
| Publisher_xml | – name: Elsevier |
| References | Hu (10.1016/j.jff.2023.105892_b0040) 2023; 138 Bajaj (10.1016/j.jff.2023.105892_b0005) 2019; 16 Kayama (10.1016/j.jff.2023.105892_b0045) 2020; 38 Sharma (10.1016/j.jff.2023.105892_b0100) 2023; 178 Zhou (10.1016/j.jff.2023.105892_b0175) 2021; 10 Shi (10.1016/j.jff.2023.105892_b0120) 2021; 69 Hong (10.1016/j.jff.2023.105892_b0035) 2016; 197 Zhang (10.1016/j.jff.2023.105892_b0170) 2022; 153 Moris (10.1016/j.jff.2023.105892_b0080) 2015; 49 Shi (10.1016/j.jff.2023.105892_b0115) 2021; 350 Nasrabadi (10.1016/j.jff.2023.105892_b0085) 2021; 118 Nie (10.1016/j.jff.2023.105892_b0090) 2021; 12 Yang (10.1016/j.jff.2023.105892_b0155) 2021; 153 Cheng (10.1016/j.jff.2023.105892_b0015) 2023; 51 Yuan (10.1016/j.jff.2023.105892_b0165) 2018; 9 Shi (10.1016/j.jff.2023.105892_b0110) 2019; 10 Yang (10.1016/j.jff.2023.105892_b0160) 2023; 12 Xiao (10.1016/j.jff.2023.105892_b0140) 2023; 174 Zhu (10.1016/j.jff.2023.105892_b0180) 2021; 147 Ding (10.1016/j.jff.2023.105892_b0020) 2022; 157 Kim (10.1016/j.jff.2023.105892_b0050) 2023; 47 Barbalho (10.1016/j.jff.2023.105892_b0010) 2019; 59 Provan (10.1016/j.jff.2023.105892_b0095) 2023; 51 Tang (10.1016/j.jff.2023.105892_b0130) 2023; 22 Yan (10.1016/j.jff.2023.105892_b0150) 2023; 162 Li (10.1016/j.jff.2023.105892_b0060) 2022; 209 Xie (10.1016/j.jff.2023.105892_b0145) 2023; 11 Lu (10.1016/j.jff.2023.105892_b0075) 2022; 277 Kumar (10.1016/j.jff.2023.105892_b0055) 2023; 295 Tang (10.1016/j.jff.2023.105892_b0135) 2021; 91 Shi (10.1016/j.jff.2023.105892_b0105) 2019; 290 Herman (10.1016/j.jff.2023.105892_b0030) 2022; 129 Liu (10.1016/j.jff.2023.105892_b0070) 2022; 157 Souza-Smith (10.1016/j.jff.2023.105892_b0125) 2023; 327 |
| References_xml | – volume: 350 year: 2021 ident: 10.1016/j.jff.2023.105892_b0115 article-title: The impact of caseinate oligochitosan-glycation by transglutaminase on amino acid compositions and immune-promoting activity in BALB/c mice of the tryptic caseinate hydrolysate publication-title: Food Chemistry doi: 10.1016/j.foodchem.2021.129302 contributor: fullname: Shi – volume: 129 start-page: 408 year: 2022 ident: 10.1016/j.jff.2023.105892_b0030 article-title: Insight into the silkworm pupae: Modification technologies and functionality of the protein and lipids publication-title: Trends in Food Science & Technology doi: 10.1016/j.tifs.2022.10.003 contributor: fullname: Herman – volume: 10 start-page: 652 year: 2019 ident: 10.1016/j.jff.2023.105892_b0110 article-title: Effect of caseinate with oligochitosan and transglutaminase on the intestinal barrier function of the tryptic caseinate digest in IEC-6 cells publication-title: Food & Function doi: 10.1039/C8FO01785A contributor: fullname: Shi – volume: 153 year: 2022 ident: 10.1016/j.jff.2023.105892_b0170 article-title: Licorice extract ameliorates hyperglycemia through reshaping gut microbiota structure and inhibiting TLR4/NF-kB signaling pathway in type 2 diabetic mice publication-title: Food Research International doi: 10.1016/j.foodres.2022.110945 contributor: fullname: Zhang – volume: 290 start-page: 246 year: 2019 ident: 10.1016/j.jff.2023.105892_b0105 article-title: Chemical features of the oligochitosan-glycated caseinate digest and its enhanced protection on barrier function of the acrylamide-injured IEC-6 cells publication-title: Food Chemistry doi: 10.1016/j.foodchem.2019.04.004 contributor: fullname: Shi – volume: 12 start-page: 822 year: 2023 ident: 10.1016/j.jff.2023.105892_b0160 article-title: Fermented soybean paste attenuates biogenic amine-induced liver damage in obese mice publication-title: Cells doi: 10.3390/cells12050822 contributor: fullname: Yang – volume: 91 year: 2021 ident: 10.1016/j.jff.2023.105892_b0135 article-title: Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway publication-title: International Immunopharmacology doi: 10.1016/j.intimp.2020.107272 contributor: fullname: Tang – volume: 138 year: 2023 ident: 10.1016/j.jff.2023.105892_b0040 article-title: Glycosylated cross-linked ovalbumin by transglutaminase in the presence of oligochitosan: Effect of enzyme action time and enhanced functional properties publication-title: Food Hydrocolloids doi: 10.1016/j.foodhyd.2023.108462 contributor: fullname: Hu – volume: 277 start-page: e118816 year: 2022 ident: 10.1016/j.jff.2023.105892_b0075 article-title: Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2021.118816 contributor: fullname: Lu – volume: 157 year: 2022 ident: 10.1016/j.jff.2023.105892_b0070 article-title: Fermented milk of cheese-derived Lactobacillus delbrueckisubsp. bulgaricus displays potentials in alleviating alcohol-induced hepatic injury and gut dysbiosis in mice publication-title: Food Research International doi: 10.1016/j.foodres.2022.111283 contributor: fullname: Liu – volume: 9 start-page: 3944 year: 2018 ident: 10.1016/j.jff.2023.105892_b0165 article-title: Impacts of glycation and transglutaminase-catalyzed glycosylation with glucosamine on the conformational structure and allergenicity of bovine b-lactoglobulin publication-title: Food & Function doi: 10.1039/C8FO00909K contributor: fullname: Yuan – volume: 51 year: 2023 ident: 10.1016/j.jff.2023.105892_b0015 article-title: Hovenia acerba Lindl. peduncles and seeds extracts ameliorate alcoholic liver injury by activating the Nrf2/HO-1 signaling pathway in LO2 cells and mice publication-title: Food Bioscience doi: 10.1016/j.fbio.2022.102224 contributor: fullname: Cheng – volume: 327 year: 2023 ident: 10.1016/j.jff.2023.105892_b0125 article-title: Chronic alcohol feeding alters lymph and plasma proteome in a rodent model publication-title: Life Sciences doi: 10.1016/j.lfs.2023.121818 contributor: fullname: Souza-Smith – volume: 162 year: 2023 ident: 10.1016/j.jff.2023.105892_b0150 article-title: Quantitative analysis and hepatoprotective mechanism of Cistanche deserticola Y.C. Ma against alcohol-induced liver injury in mice publication-title: Biomedicine & Pharmacotherapy doi: 10.1016/j.biopha.2023.114719 contributor: fullname: Yan – volume: 38 start-page: 23 year: 2020 ident: 10.1016/j.jff.2023.105892_b0045 article-title: Interaction between the microbiota, epithelia, the immune cells in the intestine publication-title: Annual Review of Immunology doi: 10.1146/annurev-immunol-070119-115104 contributor: fullname: Kayama – volume: 118 year: 2021 ident: 10.1016/j.jff.2023.105892_b0085 article-title: Modification approaches of plant-based proteins to improve their techno-functionality and use in food products publication-title: Food Hydrocolloids contributor: fullname: Nasrabadi – volume: 153 year: 2021 ident: 10.1016/j.jff.2023.105892_b0155 article-title: Wheat embryo globulin protects against acute alcohol-induced liver injury in mice publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2021.112240 contributor: fullname: Yang – volume: 69 start-page: 8787 year: 2021 ident: 10.1016/j.jff.2023.105892_b0120 article-title: Transglutaminase-mediated caseinate oligochitosan glycation enhances the effect of caseinate hydrolysate to ameliorate the LPS-induced damage on the intestinal barrier function in IEC-6 cells publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/acs.jafc.1c02858 contributor: fullname: Shi – volume: 16 start-page: 235 year: 2019 ident: 10.1016/j.jff.2023.105892_b0005 article-title: Alcohol, liver disease and the gut microbiota publication-title: Nature Reviews Gastroenterology & Hepatology doi: 10.1038/s41575-018-0099-1 contributor: fullname: Bajaj – volume: 178 year: 2023 ident: 10.1016/j.jff.2023.105892_b0100 article-title: A small animal model of NASH with progressive steatohepatitis-induced by fast food diet and alcohol in C57BL/6J mouse with high human pathophysiological proximity publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2023.113851 contributor: fullname: Sharma – volume: 12 start-page: 10053 year: 2021 ident: 10.1016/j.jff.2023.105892_b0090 article-title: Oligopeptides from Jinhua ham prevent alcohol-induced liver damage by regulating intestinal homeostasis and oxidative stress in mice publication-title: Food & Function doi: 10.1039/D1FO01693H contributor: fullname: Nie – volume: 47 start-page: 583 year: 2023 ident: 10.1016/j.jff.2023.105892_b0050 article-title: Korean red ginseng extract attenuates alcohol-induced addictive responses and cognitive impairments by alleviating neuroinflammation publication-title: Journal of Ginseng Research doi: 10.1016/j.jgr.2023.02.003 contributor: fullname: Kim – volume: 197 start-page: 1143 year: 2016 ident: 10.1016/j.jff.2023.105892_b0035 article-title: Glucosamine-induced glycation of hydrolysed meat proteins in the presence or absence of transglutaminase: Chemical modifications and taste-enhancing activity publication-title: Food Chemistry doi: 10.1016/j.foodchem.2015.11.096 contributor: fullname: Hong – volume: 22 start-page: 1986 year: 2023 ident: 10.1016/j.jff.2023.105892_b0130 article-title: Food protein glycation: A review focusing on stability and in vitro digestive characteristics of oil/water emulsions publication-title: Comprehensive Reviews in Food Science and Food Safety doi: 10.1111/1541-4337.13138 contributor: fullname: Tang – volume: 51 start-page: 331 year: 2023 ident: 10.1016/j.jff.2023.105892_b0095 article-title: Alcohol and the liver publication-title: Medicine doi: 10.1016/j.mpmed.2023.02.005 contributor: fullname: Provan – volume: 209 start-page: 858 year: 2022 ident: 10.1016/j.jff.2023.105892_b0060 article-title: Radix puerariae thomsonil polysaccharide improves inflammation and lipid peroxidation in alcohol and high-fat diet mice by regulating gut microbiota publication-title: International Journal of Biological Macromolecules doi: 10.1016/j.ijbiomac.2022.04.067 contributor: fullname: Li – volume: 157 start-page: 11259 year: 2022 ident: 10.1016/j.jff.2023.105892_b0020 article-title: Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis publication-title: Food Research International doi: 10.1016/j.foodres.2022.111259 contributor: fullname: Ding – volume: 10 start-page: 2688 year: 2021 ident: 10.1016/j.jff.2023.105892_b0175 article-title: Astragalus polysaccharides and saponins alleviate liver injury and regulate gut microbiota in alcohol liver disease mice publication-title: Foods doi: 10.3390/foods10112688 contributor: fullname: Zhou – volume: 174 year: 2023 ident: 10.1016/j.jff.2023.105892_b0140 article-title: Musculus senhousei as a promising source of bioactive peptides protecting against alcohol-induced liver injury publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2023.113652 contributor: fullname: Xiao – volume: 59 start-page: 1347 year: 2019 ident: 10.1016/j.jff.2023.105892_b0010 article-title: Associations between inflammatory bowel diseases and vitamin D publication-title: Critical Reviews in Food Science and Nutrition doi: 10.1080/10408398.2017.1406333 contributor: fullname: Barbalho – volume: 147 year: 2021 ident: 10.1016/j.jff.2023.105892_b0180 article-title: Inhibitory mechanism of catechins against advanced glycation end products of glycated myofibrillar protein through anti-aggregation and anti-oxidation publication-title: LWT-Food Science and Technology doi: 10.1016/j.lwt.2021.111550 contributor: fullname: Zhu – volume: 295 year: 2023 ident: 10.1016/j.jff.2023.105892_b0055 article-title: Anti-miR-96 and Hh pathway inhibitor MDB5 synergistically ameliorate alcohol-associated liver injury in mice publication-title: Biomaterials doi: 10.1016/j.biomaterials.2023.122049 contributor: fullname: Kumar – volume: 49 start-page: 507 year: 2015 ident: 10.1016/j.jff.2023.105892_b0080 article-title: Regional variation in expression of pro-inflammatory mediators in the intestine following a combined insult of alcohol and burn injury publication-title: Alcohol doi: 10.1016/j.alcohol.2015.02.007 contributor: fullname: Moris – volume: 11 start-page: 2148 year: 2023 ident: 10.1016/j.jff.2023.105892_b0145 article-title: Mechanism of action of buckwheat quercetin in regulating lipid metabolism and intestinal flora via TLR4/NF-kB pathway in rats on high-fat diet publication-title: Nutrition contributor: fullname: Xie |
| SSID | ssj0066130 |
| Score | 2.3923721 |
| Snippet | Glycosylated protein by transglutaminase-type could alter the structures and functional properties of proteins. However, the beneficial effects of glycosylated... |
| SourceID | doaj crossref |
| SourceType | Open Website Aggregation Database |
| StartPage | 105892 |
| SubjectTerms | Anti-oxidation Casein Glycosylation Intestinal inflammation TLR4/NF-κB |
| Title | Oligochitosan glycosylation of casein by TGase: Protective effect and mechanism on alcohol-induced intestinal injury in C57BL/6 mice |
| URI | https://doaj.org/article/6c6416c99a3d4f24bb88c81ce92aef8d |
| Volume | 111 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELYKp14QjyJeRXOoeqgUiO2sY3MDBEVVWziAxC3yY4x2tZtU3eWwF0788I7jXQQnLj0lipLImpnMI_7mG8a-1LZ2JupYWERfUH6LhXXekC0HpIDHkYvUnPzrt7q6q37cD-5fjfpKmLBMD5wFd6y8opzBG2NlqKKonNPaa-7RCItRh977lmZZTGUfrFJW3LdCDlRRqUot9zN7ZNcoJu5OIdOMW23Em4j0iri_jzCX62xtkRrCaV7SBvuA7SbbOm2pLJ7M4Sv0YM3-L_gWe74eDx-6tAfQTW0LD-O576bzjGuDLoKn4DRswc3h9judnsBN5mMg3wYZwgG2DTDB1Pg7nE6AHrN5Wm5BVTrpO0BikiAHkNY0bEckezrA-aA--3msIE2x_8TuLi9uz6-KxUCFwlNlMCuUEFGgVsHVAzSRmyCDlKVGr7XDSnhbWhkjrzFaV3L0MgQrJXqkPNFblNtste1a3GFQW269tt6ULn322pEl1NEk-jBO8c_ssm9LoTZ_Mm9GswSUjRrSQJM00GQN7LKzJPaXGxPldX-BDKFZGELzniHs_Y-X7LOPaV0Zr3LAVmd_H_EzZR0zd8hWjp74YW9m_wDCgtju |
| link.rule.ids | 315,783,787,867,2109,27937,27938 |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Oligochitosan+glycosylation+of+casein+by+TGase%3A+Protective+effect+and+mechanism+on+alcohol-induced+intestinal+injury+in+C57BL%2F6+mice&rft.jtitle=Journal+of+functional+foods&rft.au=Yu+Wang&rft.au=Yingying+Yue&rft.au=Huimin+Wang&rft.au=Yujun+Jiang&rft.date=2023-12-01&rft.pub=Elsevier&rft.issn=1756-4646&rft.volume=111&rft.spage=105892&rft_id=info:doi/10.1016%2Fj.jff.2023.105892&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_6c6416c99a3d4f24bb88c81ce92aef8d |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1756-4646&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1756-4646&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1756-4646&client=summon |