Involvement of MicroRNA-133a in the Protective Effect of Hydrogen Sulfide against Ischemia/Reperfusion-Induced Endoplasmic Reticulum Stress and Cardiomyocyte Apoptosis

• Published in: Pharmacology Vol. 103; no. 1-2; p. 1
• Main Authors: Ren, Lin, Wang, Qian, Chen, Yu, Ma, Yanzhuo, Wang, Dongmei
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2019
• Subjects: Animals; Apoptosis - drug effects; Apoptosis - genetics; Cardiotonic Agents - pharmacology; Cell Line; Disease Models, Animal; Endoplasmic Reticulum Stress - drug effects; Endoplasmic Reticulum Stress - genetics; Eukaryotic Initiation Factor-2 - metabolism; Heat-Shock Proteins - drug effects; Heat-Shock Proteins - metabolism; Hydrogen Sulfide - pharmacology; MicroRNAs - administration & dosage; MicroRNAs - biosynthesis; MicroRNAs - genetics; Myocardial Reperfusion Injury - drug therapy; Myocardial Reperfusion Injury - genetics; Myocardial Reperfusion Injury - pathology; Myocardial Reperfusion Injury - therapy; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - pathology; Rats; Rats, Sprague-Dawley; Transcription Factor CHOP - metabolism; Transfection; Hydrogen sulfide; Cardiomyocyte apoptosis; Ischemia/reperfusion; MicroRNA-133a; Endoplasmic reticulum stress

Myocardial ischemia/reperfusion (I/R) injury is a severe trauma that cells undergo and is associated with cardiomyocyte apoptosis. Recently, miRNAs have been demonstrated to play an important role in cardiovascular biology and disease. However, whether the miR-133a and ER stress play a role in hydro...