Glycine α-Ketoamides as HCV NS3 Protease Inhibitors
Using a tetrapeptide-based α-ketoamide template, various amines and amino acids were incorporated to explore the prime side of the HCV NS3 protease catalytic site. Glycine carboxylic acid was found to be the most effective prime group. Further optimization yielded an inhibitor with IC 50 of 0.060 μM...
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| Published in | Bioorganic & medicinal chemistry letters Vol. 13; no. 6; pp. 1111 - 1114 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier Ltd
24.03.2003
Elsevier |
| Subjects | |
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| Abstract | Using a tetrapeptide-based α-ketoamide template, various amines and amino acids were incorporated to explore the prime side of the HCV NS3 protease catalytic site. Glycine carboxylic acid was found to be the most effective prime group. Further optimization yielded an inhibitor with IC
50 of 0.060 μM.
A series of tetrapeptide-based α-ketoamides was designed, synthesized, and evaluated as HCV NS3 protease inhibitors. Glycine α-ketoamide
I was identified as a potent inhibitor with an IC
50 of 0.060 μM. |
|---|---|
| AbstractList | Using a tetrapeptide-based alpha-ketoamide template, various amines and amino acids were incorporated to explore the prime side of the HCV NS3 protease catalytic site. Glycine carboxylic acid was found to be the most effective prime group. Further optimization yielded an inhibitor with IC(50) of 0.060 microM. Using a tetrapeptide-based α-ketoamide template, various amines and amino acids were incorporated to explore the prime side of the HCV NS3 protease catalytic site. Glycine carboxylic acid was found to be the most effective prime group. Further optimization yielded an inhibitor with IC 50 of 0.060 μM. A series of tetrapeptide-based α-ketoamides was designed, synthesized, and evaluated as HCV NS3 protease inhibitors. Glycine α-ketoamide I was identified as a potent inhibitor with an IC 50 of 0.060 μM. |
| Author | Han, Wei Jiang, Xiangjun Decicco, Carl P. Hu, Zilun Wasserman, Zelda R. |
| Author_xml | – sequence: 1 givenname: Wei surname: Han fullname: Han, Wei email: wei.han1@bms.com – sequence: 2 givenname: Zilun surname: Hu fullname: Hu, Zilun – sequence: 3 givenname: Xiangjun surname: Jiang fullname: Jiang, Xiangjun – sequence: 4 givenname: Zelda R. surname: Wasserman fullname: Wasserman, Zelda R. – sequence: 5 givenname: Carl P. surname: Decicco fullname: Decicco, Carl P. |
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| Cites_doi | 10.1177/095632029700800401 10.1016/S0960-894X(00)00654-5 10.1046/j.1365-2893.1999.00152.x 10.1016/S0092-8674(00)81351-3 10.1016/S0960-894X(01)00843-5 10.1128/JVI.74.4.2046-2051.2000 10.1074/jbc.275.10.7152 10.1016/S0960-894X(01)00842-3 10.1021/jo00095a005 10.1021/bi025603x 10.1021/bi980314n 10.1021/jo010164d 10.1016/S0960-894X(00)00465-0 10.1074/jbc.274.26.18618 10.1126/science.277.5325.570 10.1016/S0960-894X(00)00074-3 10.1016/S0969-2126(00)80025-8 10.1016/S0092-8674(00)81350-1 10.1016/S0960-894X(98)00480-6 |
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| Keywords | Ketoamide Peptides Serine endopeptidases Enzyme Active site Enzyme inhibitor Pyrazine derivatives Inhibitor enzyme complex In vitro Modeling Virus Peptidases Tetrapeptide Molecular model Hydrolases Antiviral Carboxamide Flaviviridae Hepatitis C virus Hepacivirus Protease inhibitor Pentapeptide |
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| References | Ingallinella, Altamura, Bianchi, Taliani, Ingenito, Cortese, De Francesco, Steinkühler, Pessi (BIB12) 1998; 37 Bartenschlager (BIB5) 1999; 6 3rd ed.; Raven: New York, 1996; p 1035. Kolykhalov, Agapov, Blight, Mihalik, Feinstone, Rice, Kolykhalov, Mihalik, Feinstone, Rice (BIB4) 1997; 277 Love, Parge, Wickersham, Hostomsky, Habuka, Moomaw, Adachi, Hostomska, Kim, Morgenstern, Lin, Fox, Dwyer, Landro, Chambers, Markland, Lepre, O'Malley, Harbeson, Yao, Reichert, Taremi, Prosise, Weber (BIB6) 1996; 87 (b) Han, W.; Jiang, X.-J.; Hu, Z.-L.; Wasserman, Z. R.; Decicco, C. P. National Meeting of the American Chemical Society, San Diego, Apr. 2001; MEDI-119 and MEDI-121. Poupart, Cameron, Chabot, Ghiro, Goudreau, Goulet, Poirier, Tsantrizos, Llinàs-Brunet, Bailey, Fazal, Ghiro, Gorys, Goulet, Halmos, Maurice, Poirier, Poupart, Rancourt, Thibeault, Wernic, Lamarre (BIB13) 2001; 66 Narjes, Koehler, Koch, Gerlach, Colarusso, Steinkühler, Brunetti, Altamura, De Francesco, Matassa (BIB14) 2002; 12 Houghton, M. In Ingallinella, Fattori, Altamura, Steinkühler, Koch, Cicero, Bazzo, Cortese, Bianchi, Pessi (BIB9) 2002; 41 LaPlante, Cameron, Aubry, Lefebvre, Kukolj, Maurice, Thibeault, Lamarre, Llinàs-Brunet, DiMarco, Rizzi, Volpari, Walsh, Narjes, Colarusso, De Francesco, Matassa, Sollazzo (BIB3) 1999; 274 Bartenschlager (BIB2) 1997; 8 Bennett, Campbell, Campbell, Carr, Dunsdon, Greening, Hurst, Jennings, Jones, Jordan, Kay, O'Brien, King-Underwood, Raynham, Wilkinson, Wilkinson, Wilson, Llinàs-Brunet, Bailey, Déziel, Fazal, Gorys, Goulet, Halmos, Maurice, Poirier, Poupart, Rancourt, Thibeault, Wernic, Lamarre (BIB8) 2001; 11 BIB10 Colarusso, Gerlach, Koch, Muraglia, Conte, Stansfield, Matassa, Narjes (BIB11) 2002; 12 Wasserman, Ho (BIB15) 1994; 59 LaPlante (10.1016/S0960-894X(03)00031-3_BIB3_1) 1999; 274 Llinàs-Brunet (10.1016/S0960-894X(03)00031-3_BIB13_2) 2000; 10 Narjes (10.1016/S0960-894X(03)00031-3_BIB14) 2002; 12 Love (10.1016/S0960-894X(03)00031-3_BIB6_1) 1996; 87 Kim (10.1016/S0960-894X(03)00031-3_BIB6_2) 1996; 87 Llinàs-Brunet (10.1016/S0960-894X(03)00031-3_BIB8_2) 1998; 8 10.1016/S0960-894X(03)00031-3_BIB1 Kolykhalov (10.1016/S0960-894X(03)00031-3_BIB4_2) 2000; 74 Yao (10.1016/S0960-894X(03)00031-3_BIB6_3) 1999; 7 Poupart (10.1016/S0960-894X(03)00031-3_BIB13_1) 2001; 66 DiMarco (10.1016/S0960-894X(03)00031-3_BIB3_2) 2000; 275 Kolykhalov (10.1016/S0960-894X(03)00031-3_BIB4_1) 1997; 277 Bartenschlager (10.1016/S0960-894X(03)00031-3_BIB5) 1999; 6 Ingallinella (10.1016/S0960-894X(03)00031-3_BIB12) 1998; 37 Bennett (10.1016/S0960-894X(03)00031-3_BIB8_1) 2001; 11 Bartenschlager (10.1016/S0960-894X(03)00031-3_BIB2) 1997; 8 Han (10.1016/S0960-894X(03)00031-3_BIB7_1) 2000; 10 10.1016/S0960-894X(03)00031-3_BIB7_2 Wasserman (10.1016/S0960-894X(03)00031-3_BIB15) 1994; 59 Colarusso (10.1016/S0960-894X(03)00031-3_BIB11) 2002; 12 Ingallinella (10.1016/S0960-894X(03)00031-3_BIB9) 2002; 41 |
| References_xml | – volume: 274 start-page: 18618 year: 1999 ident: BIB3 publication-title: J. Biol. Chem. contributor: fullname: Sollazzo – volume: 87 start-page: 331 year: 1996 ident: BIB6 publication-title: Cell contributor: fullname: Weber – volume: 41 start-page: 5483 year: 2002 ident: BIB9 publication-title: Biochemistry contributor: fullname: Pessi – volume: 66 start-page: 4743 year: 2001 ident: BIB13 publication-title: J. Org. Chem. contributor: fullname: Lamarre – volume: 12 start-page: 701 year: 2002 ident: BIB14 publication-title: Bioorg. Med. Chem. Lett. contributor: fullname: Matassa – volume: 12 start-page: 705 year: 2002 ident: BIB11 publication-title: Bioorg. Med. Chem. Lett. contributor: fullname: Narjes – volume: 277 start-page: 570 year: 1997 ident: BIB4 publication-title: Science contributor: fullname: Rice – ident: BIB10 – volume: 6 start-page: 165 year: 1999 ident: BIB5 publication-title: J. Viral Hepatitis contributor: fullname: Bartenschlager – volume: 11 start-page: 355 year: 2001 ident: BIB8 publication-title: Bioorg. Med. Chem. Lett. contributor: fullname: Lamarre – volume: 37 start-page: 8906 year: 1998 ident: BIB12 publication-title: Biochemistry contributor: fullname: Pessi – volume: 8 start-page: 281 year: 1997 ident: BIB2 publication-title: Antiviral Chem. Chemother. contributor: fullname: Bartenschlager – volume: 59 start-page: 4364 year: 1994 ident: BIB15 publication-title: J. Org. Chem. contributor: fullname: Ho – volume: 8 start-page: 281 year: 1997 ident: 10.1016/S0960-894X(03)00031-3_BIB2 publication-title: Antiviral Chem. Chemother. doi: 10.1177/095632029700800401 contributor: fullname: Bartenschlager – volume: 11 start-page: 355 year: 2001 ident: 10.1016/S0960-894X(03)00031-3_BIB8_1 publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(00)00654-5 contributor: fullname: Bennett – ident: 10.1016/S0960-894X(03)00031-3_BIB1 – volume: 6 start-page: 165 year: 1999 ident: 10.1016/S0960-894X(03)00031-3_BIB5 publication-title: J. Viral Hepatitis doi: 10.1046/j.1365-2893.1999.00152.x contributor: fullname: Bartenschlager – volume: 87 start-page: 343 year: 1996 ident: 10.1016/S0960-894X(03)00031-3_BIB6_2 publication-title: Cell doi: 10.1016/S0092-8674(00)81351-3 contributor: fullname: Kim – volume: 12 start-page: 705 year: 2002 ident: 10.1016/S0960-894X(03)00031-3_BIB11 publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(01)00843-5 contributor: fullname: Colarusso – ident: 10.1016/S0960-894X(03)00031-3_BIB7_2 – volume: 74 start-page: 2046 year: 2000 ident: 10.1016/S0960-894X(03)00031-3_BIB4_2 publication-title: J. Virol. doi: 10.1128/JVI.74.4.2046-2051.2000 contributor: fullname: Kolykhalov – volume: 275 start-page: 7152 year: 2000 ident: 10.1016/S0960-894X(03)00031-3_BIB3_2 publication-title: J. Biol. Chem. doi: 10.1074/jbc.275.10.7152 contributor: fullname: DiMarco – volume: 12 start-page: 701 year: 2002 ident: 10.1016/S0960-894X(03)00031-3_BIB14 publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(01)00842-3 contributor: fullname: Narjes – volume: 59 start-page: 4364 year: 1994 ident: 10.1016/S0960-894X(03)00031-3_BIB15 publication-title: J. Org. Chem. doi: 10.1021/jo00095a005 contributor: fullname: Wasserman – volume: 41 start-page: 5483 year: 2002 ident: 10.1016/S0960-894X(03)00031-3_BIB9 publication-title: Biochemistry doi: 10.1021/bi025603x contributor: fullname: Ingallinella – volume: 37 start-page: 8906 year: 1998 ident: 10.1016/S0960-894X(03)00031-3_BIB12 publication-title: Biochemistry doi: 10.1021/bi980314n contributor: fullname: Ingallinella – volume: 66 start-page: 4743 year: 2001 ident: 10.1016/S0960-894X(03)00031-3_BIB13_1 publication-title: J. Org. Chem. doi: 10.1021/jo010164d contributor: fullname: Poupart – volume: 10 start-page: 2267 year: 2000 ident: 10.1016/S0960-894X(03)00031-3_BIB13_2 publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(00)00465-0 contributor: fullname: Llinàs-Brunet – volume: 274 start-page: 18618 year: 1999 ident: 10.1016/S0960-894X(03)00031-3_BIB3_1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.26.18618 contributor: fullname: LaPlante – volume: 277 start-page: 570 year: 1997 ident: 10.1016/S0960-894X(03)00031-3_BIB4_1 publication-title: Science doi: 10.1126/science.277.5325.570 contributor: fullname: Kolykhalov – volume: 10 start-page: 711 year: 2000 ident: 10.1016/S0960-894X(03)00031-3_BIB7_1 publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(00)00074-3 contributor: fullname: Han – volume: 7 start-page: 1353 year: 1999 ident: 10.1016/S0960-894X(03)00031-3_BIB6_3 publication-title: Structure doi: 10.1016/S0969-2126(00)80025-8 contributor: fullname: Yao – volume: 87 start-page: 331 year: 1996 ident: 10.1016/S0960-894X(03)00031-3_BIB6_1 publication-title: Cell doi: 10.1016/S0092-8674(00)81350-1 contributor: fullname: Love – volume: 8 start-page: 2719 year: 1998 ident: 10.1016/S0960-894X(03)00031-3_BIB8_2 publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(98)00480-6 contributor: fullname: Llinàs-Brunet |
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| SubjectTerms | Amides - chemical synthesis Amides - pharmacology Amines - chemistry Amino Acids - chemistry Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Binding Sites Biological and medical sciences Glycine - analogs & derivatives Glycine - chemical synthesis Glycine - pharmacology Hepacivirus - enzymology Medical sciences Pharmacology. Drug treatments Protease Inhibitors - chemical synthesis Structure-Activity Relationship Viral Nonstructural Proteins - metabolism |
| Title | Glycine α-Ketoamides as HCV NS3 Protease Inhibitors |
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