Role of the Ubiquitin C-Terminal Hydrolase L1-Modulated Ubiquitin Proteasome System in Auditory Cortex Senescence

• Published in: O.R.L. Journal for oto-rhino-laryngology and its related specialties Vol. 79; no. 3; p. 153
• Main Authors: Zhang, Ya, Huang, Xiang, Zhao, Xue-Yan, Hu, Yu-Juan, Sun, Hai-Ying, Kong, Wei-Jia
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2017
• Subjects: Aging - metabolism; Analysis of Variance; Animals; Auditory Cortex - metabolism; Biomarkers - analysis; Blotting, Western; Cells, Cultured; Disease Models, Animal; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Sensitivity and Specificity; Ubiquitin Thiolesterase - metabolism; Ubiquitin; Aging; PSMA7; UBE1; Proteasome

According to recent studies, central auditory impairments are closely related to neurodegenerative diseases. However, the mechanism of central presbycusis remains unclear. Ubiquitin C-terminal hydrolase L1 (UCHL1) is important in maintaining proteasomal activity; however, the detailed mechanism has...