Electrochemical sensing of acetaminophen, phenylephrine hydrochloride and cytosine in drugs and blood serum samples using β-AgVO3/ZrO2@g-C3N4 composite coated GC electrode

• Published in: Journal of molecular liquids Vol. 348; p. 118447
• Main Authors: Murugan, E., Poongan, A., Dhamodharan, A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.02.2022
• Subjects: Acetaminophen; Cytosine; Differential Pulse Voltammetry; Electrochemical sensing; Phenylephrine hydrochloride; β-AgVO3/ZrO2@g-C3N4 ternary Nanocomposite; β-AgVO3/ZrO2@g-C3N4 ternary Nanocomposite; Phenylephrine hydrochloride; Differential Pulse Voltammetry; Electrochemical sensing; Cytosine; Acetaminophen
• DOI: 10.1016/j.molliq.2021.118447
• ISSN: 0167-7322

[Display omitted] •β-AgVO3/ZrO2@g-C3N4 is an excellent electrochemical sensor.•AAP, PPH and CTS drugs can be separately and simultaneously sensed.•The sensor exhibits good sensitivity, stability, repeatability and reproducibility.•The same drugs in real samples are also successfully detected.•The sensor can be easily fabricated. In the recent past, the development of electrochemical sensors that can simultaneously sense different drugs has received great attention in the medical area. In the present study, a composite, β-AgVO3/ZrO2@g-C3N4/GCE, was developed and used for a concomitant determination of three drugs viz., acetaminophen (AAP), phenylephrine hydrochloride (PPH) and cytosine (CTS). The fabricated composite was characterized by XRD, FTIR, Raman, and HR-SEM. The purity of the individual components of the composite was established by their respective XRD patterns. HR-SEM exhibited rod shape for β-AgVO3. The results of electrochemical analysis of AAP, PPH and CTS depicted resolved peak potentials. The linear range corresponding to the detection of AAP, PPH and CTS was equal to 0.0055 to 149, 0.0049 to 56, and 0.0045 to 223.2 μM, respectively. Similarly, the low detection limit (LOD) for AAP, PPH and CTS was 8.3, 8.6 and 5.1 nM, respectively. The results demonstrate high sensitivity of the modified electrode. The electrode’s reproducibility, selectivity, stability and repeatability were also established. The simultaneous determination of the drugs in the real samples such as blood serum, tablets and calf thymus DNA were also successfully achieved. So, the electrode composite is verified as a good choice for commercial sensor fabrication. In this manner, the present electrode can hold an incredible guarantee for recognizable proof and evaluation of medications in a mixture.