Environmental influences on fatty acid composition of membranes from autoimmune MRL lpr/lpr mice

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 54; no. 4; pp. 297 - 302
• Main Authors: Hackshaw, Kevin V., Kunesh, Sarah L., Jackson, Nkenge A., Culpepper, Chantal
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.04.1996; Elsevier
• Subjects: 6-Ketoprostaglandin F1 alpha - analysis; Animals; Autoimmune Diseases - immunology; Autoimmune Diseases - metabolism; Biological and medical sciences; Disease Models, Animal; Experimental and animal immunopathology. Animal models; Fatty Acids - analysis; Fibroblast Growth Factor 1 - pharmacology; Fibroblast Growth Factor 2 - pharmacology; Immunopathology; Kidney - metabolism; Leukotriene C4 - analysis; Liver - metabolism; Macrophages, Peritoneal - drug effects; Macrophages, Peritoneal - immunology; Macrophages, Peritoneal - metabolism; Medical sciences; Membrane Lipids - metabolism; Mice; Mice, Inbred MRL lpr; Phospholipids - analysis; Tetradecanoylphorbol Acetate - pharmacology; Immunopathology; Fibroblast growth factor; Vertebrata; Mammalia; Mouse; Animal; Rodentia; Plasma membrane; Lipids; Autoimmune disease; Inflammation; Fatty acids

We analyzed fatty acid make up of cells and organs from autoimmune and immunologically normal mice to determine whether intrinsic differences in composition might be associated with an inflammatory phenotype. Macrophages (MØ) isolated from 4–6-week-old MRL lpr/lpr mice were cultured with phorbol est...