Copper-catalysed meso-bislactone ring opening using Grignard and mixed triorganozinc reagents

An efficient copper-mediated S N2′ ring-opening reaction of a meso-bislactone has been developed using Grignard reagents and, for the first time, mixed triorganozinc reagents.

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Bibliographic Details
Published inTetrahedron letters Vol. 47; no. 40; pp. 7205 - 7208
Main Authors Borthwick, Scott, Dohle, Wolfgang, Hirst, Paul R., Booker-Milburn, Kevin I.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 02.10.2006
Elsevier
Subjects
Chemistry
Chemistry, Organic
Desymmetrisation
Grignard
meso-Bislactone
Organocopper
Organozinc
Physical Sciences
Science & Technology
Organozinc
Desymmetrisation
Grignard
meso-Bislactone
Organocopper
SUBSTITUTION
organozinc
meso-bislactone
ENANTIOSELECTIVE SYNTHESIS
desymmetrisation
ESTERS
organocopper
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Summary:An efficient copper-mediated S N2′ ring-opening reaction of a meso-bislactone has been developed using Grignard reagents and, for the first time, mixed triorganozinc reagents.
Bibliography:researchfish
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.07.146