Modulation of the binding affinity of naproxen to bovine serum albumin by conversion of the drug into amino acid ester salts

• Published in: Journal of molecular liquids Vol. 319; p. 114283
• Main Authors: Ossowicz, Paula, Janus, Ewa, Klebeko, Joanna, Światek, Ewelina, Kardaleva, Proletina, Taneva, Stefka, Krachmarova, Elena, Rangelov, Miroslav, Todorova, Nadezhda, Guncheva, Maya
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2020
• Subjects: Albumin; Binding affinity; Ionic liquids; Isothermal titration calorimetry; Molecular docking; Naproxen derivatives; Ionic liquids; Albumin; Binding affinity; Isothermal titration calorimetry; Naproxen derivatives; Molecular docking

Naproxen (NAP) is one of the most widely prescribed non-steroidal anti-inflammatory drugs. Novel formulations of NAP aiming at better water-solubility, dosage, and the onset of action or new routes of application in order to minimize or prevent side effects of NAP are in the current interest of the...