Asymmetric hydrogenation of ketones using Ir(III) complexes of N-alkyl- N’-tosyl-1,2-ethanediamine ligands

• Published in: Tetrahedron letters Vol. 50; no. 6; pp. 688 - 692
• Main Authors: Martins, José E.D., Morris, David J., Wills, Martin
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 11.02.2009

The combination of an enantiomerically pure N′-alkylated derivative of N-4-toluenesulfonyl-1,2-diphenylethane-1,2-diamine (TsDPEN) with iridium trichloride results in the formation of a catalyst with high selectivity for ketone hydrogenation. Products with enantiomeric excesses of up to 84% were for...