An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship
[Display omitted] A low-toxic ternary complex composed of anionic liposomes, cationic polylysine and slightly negative micelles from a polylactide– polyethylene glycol diblock copolymer is described. Liposomes with the encapsulated antitumor antibiotic Doxorubicin (Dox) retain their integrity after...
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| Published in | Mendeleev communications Vol. 27; no. 3; pp. 299 - 301 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.05.2017
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| Online Access | Get full text |
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| Abstract | [Display omitted]
A low-toxic ternary complex composed of anionic liposomes, cationic polylysine and slightly negative micelles from a polylactide– polyethylene glycol diblock copolymer is described. Liposomes with the encapsulated antitumor antibiotic Doxorubicin (Dox) retain their integrity after incorporation into the ternary complex. The incubation of cells with the Dox-loaded ternary complex leads to its penetration into the cells, the release of Dox from liposomes and predominant drug accumulation in cell nuclei. The ternary complex degrades to nanoparticles in the presence of proteolytic enzymes to produce low-toxic digestion products. |
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| AbstractList | [Display omitted]
A low-toxic ternary complex composed of anionic liposomes, cationic polylysine and slightly negative micelles from a polylactide– polyethylene glycol diblock copolymer is described. Liposomes with the encapsulated antitumor antibiotic Doxorubicin (Dox) retain their integrity after incorporation into the ternary complex. The incubation of cells with the Dox-loaded ternary complex leads to its penetration into the cells, the release of Dox from liposomes and predominant drug accumulation in cell nuclei. The ternary complex degrades to nanoparticles in the presence of proteolytic enzymes to produce low-toxic digestion products. |
| Author | Grozdova, Irina D. Razuvaeva, Ekaterina V. Kulebyakina, Alevtina I. Ezhov, Alexander A. Efimova, Anna A. Melik-Nubarov, Nickolay S. Chvalun, Sergey N. Yaroslavov, Alexander A. Rudenskaya, Galina N. |
| Author_xml | – sequence: 1 givenname: Alexander A. surname: Yaroslavov fullname: Yaroslavov, Alexander A. organization: Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation – sequence: 2 givenname: Anna A. surname: Efimova fullname: Efimova, Anna A. email: ephimova@genebee.msu.su organization: Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation – sequence: 3 givenname: Galina N. surname: Rudenskaya fullname: Rudenskaya, Galina N. organization: Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation – sequence: 4 givenname: Nickolay S. surname: Melik-Nubarov fullname: Melik-Nubarov, Nickolay S. organization: Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation – sequence: 5 givenname: Irina D. surname: Grozdova fullname: Grozdova, Irina D. organization: Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation – sequence: 6 givenname: Alexander A. surname: Ezhov fullname: Ezhov, Alexander A. organization: Department of Physics, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation – sequence: 7 givenname: Sergey N. surname: Chvalun fullname: Chvalun, Sergey N. organization: National Research Centre ‘Kurchatov Institute’, 123182 Moscow, Russian Federation – sequence: 8 givenname: Alevtina I. surname: Kulebyakina fullname: Kulebyakina, Alevtina I. organization: National Research Centre ‘Kurchatov Institute’, 123182 Moscow, Russian Federation – sequence: 9 givenname: Ekaterina V. surname: Razuvaeva fullname: Razuvaeva, Ekaterina V. organization: National Research Centre ‘Kurchatov Institute’, 123182 Moscow, Russian Federation |
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