Molecular insight into silk fibroin based delivery vehicle for amphiphilic drugs: Synthesis, characterization and molecular dynamics studies
Recent emergence of natural biopolymers as drug delivery vehicles is attributed to their biodegradability and less systemic toxicity. Here, we have synthesized curcumin, indomethacin and emodin-loaded silk fibroin nanoparticles (SFNs) and characterized several pharmacokinetic parameters (Drug Loadin...
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Published in | Journal of molecular liquids Vol. 299; p. 112156 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.02.2020
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Abstract | Recent emergence of natural biopolymers as drug delivery vehicles is attributed to their biodegradability and less systemic toxicity. Here, we have synthesized curcumin, indomethacin and emodin-loaded silk fibroin nanoparticles (SFNs) and characterized several pharmacokinetic parameters (Drug Loading and Entrapment Efficiency). Silk fibroin is a highly promising bio-material with impressive mechanical properties, high bio-compatibility and it does not exert any immunological responses in vivo. Our results show that emodin almost released completely within 144 h, however a steady release profile has been observed for indomethacin which is attributed to its moderate loading and Entrapment Efficiency by SFNs. On the other hand, complete release of curcumin is not observed even in 168 h. Curcumin also shows very promising Drug Loading and Entrapment Efficiency when loaded within the SFNs matrix. Molecular level characterization with the aid of blind docking and molecular dynamics simulation reveals that the Entrapment efficiency of the drugs exactly follows the interaction energy patterns obtained from MM/PBSA calculation, i.e., curcumin > indomethacin > emodin. Strong binding energy of curcumin with the fibroin protein is attributed to the formation of more number of hydrogen bonds compared to the other two drugs and involvement in additional π-π stacking interactions. Indomethacin interacts moderately with the SFN primarily mediated through several van der Waals interactions which accounts for its sustained release from the SFN matrix. Emodin interacts with the fibroin protein very weakly which is responsible for its low encapsulation and observed diffusion controlled release behavior within the fibroin matrix.
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•Amphiphilic drugs-loaded silk fibroin nanoparticles have been synthesized and characterized.•Encapsulation efficiency of the drugs exactly follows the interaction energy patterns.•Curcumin interacts with protein matrix through hydrogen bonds and π-π stacking interactions.•Indomethacin interacts moderately with the SFN mediated by van der Waals interactions.•Emodin interacts with the fibroin protein very weakly leads to diffusion controlled release. |
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AbstractList | Recent emergence of natural biopolymers as drug delivery vehicles is attributed to their biodegradability and less systemic toxicity. Here, we have synthesized curcumin, indomethacin and emodin-loaded silk fibroin nanoparticles (SFNs) and characterized several pharmacokinetic parameters (Drug Loading and Entrapment Efficiency). Silk fibroin is a highly promising bio-material with impressive mechanical properties, high bio-compatibility and it does not exert any immunological responses in vivo. Our results show that emodin almost released completely within 144 h, however a steady release profile has been observed for indomethacin which is attributed to its moderate loading and Entrapment Efficiency by SFNs. On the other hand, complete release of curcumin is not observed even in 168 h. Curcumin also shows very promising Drug Loading and Entrapment Efficiency when loaded within the SFNs matrix. Molecular level characterization with the aid of blind docking and molecular dynamics simulation reveals that the Entrapment efficiency of the drugs exactly follows the interaction energy patterns obtained from MM/PBSA calculation, i.e., curcumin > indomethacin > emodin. Strong binding energy of curcumin with the fibroin protein is attributed to the formation of more number of hydrogen bonds compared to the other two drugs and involvement in additional π-π stacking interactions. Indomethacin interacts moderately with the SFN primarily mediated through several van der Waals interactions which accounts for its sustained release from the SFN matrix. Emodin interacts with the fibroin protein very weakly which is responsible for its low encapsulation and observed diffusion controlled release behavior within the fibroin matrix.
[Display omitted]
•Amphiphilic drugs-loaded silk fibroin nanoparticles have been synthesized and characterized.•Encapsulation efficiency of the drugs exactly follows the interaction energy patterns.•Curcumin interacts with protein matrix through hydrogen bonds and π-π stacking interactions.•Indomethacin interacts moderately with the SFN mediated by van der Waals interactions.•Emodin interacts with the fibroin protein very weakly leads to diffusion controlled release. |
ArticleNumber | 112156 |
Author | Peña-García, Jorge Pérez-Sánchez, Horacio Villora, Gloria Verli, Hugo Montalbán, Mercedes G. Chakraborty, Sandipan Díaz-Baños, F. Guillermo |
Author_xml | – sequence: 1 givenname: Mercedes G. surname: Montalbán fullname: Montalbán, Mercedes G. organization: Department of Chemical Engineering, University of Murcia, Murcia, Spain – sequence: 2 givenname: Sandipan surname: Chakraborty fullname: Chakraborty, Sandipan organization: School of Chemical Sciences, Indian Association for the Cultivation of Science, Kolkata, India – sequence: 3 givenname: Jorge surname: Peña-García fullname: Peña-García, Jorge organization: Bioinformatics and High Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain – sequence: 4 givenname: Hugo surname: Verli fullname: Verli, Hugo organization: Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9500, CP 15005, Porto Alegre, 91500-970, RS, Brazil – sequence: 5 givenname: Gloria surname: Villora fullname: Villora, Gloria organization: Department of Chemical Engineering, University of Murcia, Murcia, Spain – sequence: 6 givenname: Horacio surname: Pérez-Sánchez fullname: Pérez-Sánchez, Horacio email: hperez@ucam.edu organization: Bioinformatics and High Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain – sequence: 7 givenname: F. Guillermo surname: Díaz-Baños fullname: Díaz-Baños, F. Guillermo email: fgb@um.es organization: Department of Physical Chemistry, University of Murcia, Murcia, Spain |
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Cites_doi | 10.1016/j.colsurfb.2016.03.056 10.1016/j.ejpb.2016.07.003 10.1016/j.biomaterials.2009.02.006 10.1007/s10856-015-5606-0 10.1016/0378-8741(96)01397-9 10.1002/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H 10.1016/j.cbi.2008.05.003 10.1016/j.jconrel.2010.11.007 10.1016/j.addr.2012.09.043 10.1142/S0192415X96000189 10.1021/jp003020w 10.1021/acs.jpclett.9b01591 10.1093/bioinformatics/btt055 10.1517/17425247.2011.568936 10.1039/C5DT00378D 10.1002/app.41702 10.1038/nrd3499 10.1038/am.2015.114 10.1016/j.fct.2008.05.030 10.3389/fphar.2015.00286 10.1007/s11051-006-9162-x 10.1126/science.1095833 10.1002/jcc.20291 10.1016/j.progpolymsci.2007.05.013 10.1063/1.2408420 10.1021/ct7000045 10.1016/j.biomaterials.2010.02.024 10.1016/j.lfs.2005.12.007 10.1016/0010-4655(95)00042-E 10.1002/jcc.21334 10.1063/1.464397 10.1063/1.328693 10.1016/S0304-3835(01)00655-3 10.1002/jcc.540050204 10.1021/jm300621j 10.1038/natrevmats.2016.71 10.1039/C6RA12491G 10.1074/jbc.M404751200 10.1016/j.progpolymsci.2015.02.001 10.1039/C6CS00177G 10.1016/j.ijpharm.2016.12.046 10.1016/j.msec.2015.05.003 10.1021/ja048548j 10.1002/jcc.540110404 10.1517/17425247.2016.1163334 10.1016/j.canlet.2004.09.041 10.1016/j.biomaterials.2006.12.004 10.1056/NEJM198808113190602 10.1016/j.msec.2016.11.085 10.1186/1756-0500-5-367 10.1016/j.jmb.2012.02.040 10.1021/ct700301q 10.3390/nano8020126 10.1007/s10822-013-9644-8 10.2174/092986710789957760 10.1016/j.jconrel.2005.12.009 10.1016/j.ejmech.2009.03.020 |
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References | Ak, Gülçin (bb0130) 2008; 174 Chen, Neerman, Parrish, Simanek (bb0060) 2004; 126 Trott, Olson (bb0230) 2010; 31 Mukhopadhyay, Maity, Chakraborty, Rudra, Ghodadara, Solanki, Chakraborti, Prajapati, Kundu (bb0035) 2016; 6 Besler, Merz, Kollman (bb0215) 1990; 11 Wenk, Merkle, Meinel (bb0065) 2011; 150 Allen, Cullis (bb0005) 2004; 303 Lee, Kim, Harburg, Park, Ma, Pan, Kim, Lee, Kim, Jang, Kang, Huang, Kim, Lee, Leal, Rogers (bb0050) 2015; 7 Kongton, Ratanavaraporn, Kitsongsermthon, Damrongsakkul (bb0310) 2016 Bussi, Donadio, Parrinello (bb0290) 2007; 126 Hess, Bekker, Berendsen, Fraaije (bb0280) 1997; 18 Montalbán, Coburn, Lozano-Pérez, Cenis, Víllora, Kaplan (bb0120) 2018; 8 Singh, Kollman (bb0210) 1984; 5 Pronk, Páll, Schulz, Larsson, Bjelkmar, Apostolov, Shirts, Smith, Kasson, van der Spoel, Hess, Lindahl (bb0250) 2013; 29 Duvoix, Blasius, Delhalle, Schnekenburger, Morceau, Henry, Dicato, Diederich (bb0135) 2005; 223 Chang, Lin, Yang, Namba, Hattori (bb0190) 1996; 24 Hofmann, Wong Po Foo, Rossetti, Textor, Vunjak-Novakovic, Kaplan, Merkle, Meinel (bb0085) 2006; 111 Koh, Cheng, Teng, Khin, Loh, Tee, Low, Ye, Yu, Zhang, Han (bb0100) 2015; 46 Li, Mooney (bb0010) 2016; 1 Ordikhani, Dehghani, Simchi (bb0045) 2015; 26 Goel, Boland, Chauhan (bb0145) 2001; 172 Van Der Spoel, Lindahl, Hess, Groenhof, Mark, Berendsen (bb0245) 2005; 26 Navarro-Fernández, Pérez-Sánchez, Martínez-Martínez, Meliciani, Guerrero, Vicente, Corral, Wenzel (bb0235) 2012; 55 Showalter, Brüschweiler (bb0270) 2007; 3 Hess, Kutzner, van der Spoel, Lindahl (bb0255) 2008; 4 Sousa da Silva, Vranken (bb0265) 2012; 5 Pecere, Gazzola, Mucignat, Parolin, Vecchia, Cavaggioni, Basso, Diaspro, Salvato, Carli, Palù (bb0180) 2000; 60 Lin, Chang, Yang, Namba, Hattori (bb0185) 1996; 52 Lozano-Pérez, Gil, Pérez, Cutillas, Meyer, Pedreño, D. Aznar-Cervantes, Janiak, Cenis, Ruiz (bb0300) 2015; 44 Leonarduzzi, Testa, Sottero, Gamba, Poli (bb0030) 2010; 17 Martínez-Ballesta, Pérez-Sánchez, Moreno, Carvajal (bb0240) 2016; 143 Lozano-Pérez, Montalbán, Aznar-Cervantes, Cragnolini, Cenis, Víllora (bb0200) 2015; 132 Yoo, Irvine, Discher, Mitragotri (bb0015) 2011; 10 Mark, Nilsson (bb0275) 2001; 105 Vepari, Kaplan (bb0070) 2007; 32 Madhavi Sastry, Adzhigirey, Day, Annabhimoju, Sherman (bb0225) 2013; 27 Gonçalves, Gurikov, Poejo, Matias, Heinrich, Duarte, Smirnova (bb0040) 2016; 107 Catto, Farè, Cattaneo, Figliuzzi, Alessandrino, Freddi, Remuzzi, Tanzi (bb0105) 2015; 54 Pritchard, Kaplan (bb0075) 2011; 8 Darden, York, Pedersen (bb0285) 1993; 98 Lee, Ab. Aziz, Syahida, Abas, Shaari, Israf, Lajis (bb0140) 2009; 44 Zhang, Shen, Xiang, Zhuge, Gao, Wang (bb0205) 2007; 9 Subia, Kundu (bb0305) 2012; 24 Rother, Nussbaumer, Renggli, Bruns (bb0025) 2016; 45 Moise, Huhta, Sharif, Ou, Kirshon, Wasserstrum, Cano (bb0175) 1988; 319 Wongpinyochit, Vassileiou, Gupta, Mushrif, Johnston, Seib (bb0195) 2019; 10 Lammel, Hu, Park, Kaplan, Scheibel (bb0110) 2010; 31 Maheshwari, Singh, Gaddipati, Srimal (bb0165) 2006; 78 Mandal, Kundu (bb0080) 2009; 30 Berendsen, van der Spoel, van Drunen (bb0260) 1995; 91 Parrinello, Rahman (bb0295) 1981; 52 Bisht, Jaiswal, Chen, Jin, Rupenthal (bb0055) 2016; 13 He, Zhang, Li, Jia, Chen, Zhou, Zhang, Chen, Zhou (bb0220) 2012; 418 Lozano-Pérez, Rivero, Pérez Hernández, Pagán, Montalbán, Víllora, Cénis (bb0125) 2017; 518 Yang, Lim, Begum, Ubeda, Simmons, Ambegaokar, Chen, Kayed, Glabe, Frautschy, Cole (bb0150) 2005; 280 Park, Kim, Cho, Kwon, Phark, Hwang, Sul (bb0155) 2008; 46 Sercombe, Veerati, Moheimani, Wu, Sood, Hua (bb0020) 2015; 6 Kundu, Rajkhowa, Kundu, Wang (bb0090) 2013; 65 Li, Liu, Zhang, You, Qu, Li (bb0115) 2017; 72 Zuckerman, Reiss, Rubinstein (bb0170) 1974; 44 Mathew, Fukuda, Nagaoka, Hasumura, Morimoto, Yoshida, Maekawa, Venugopal, Kumar (bb0160) 2012; 7 Yang, Chen, Ding, Zhang, Liu, Gu (bb0095) 2007; 28 Kongton (10.1016/j.molliq.2019.112156_bb0310) 2016 Vepari (10.1016/j.molliq.2019.112156_bb0070) 2007; 32 Mukhopadhyay (10.1016/j.molliq.2019.112156_bb0035) 2016; 6 Parrinello (10.1016/j.molliq.2019.112156_bb0295) 1981; 52 Yang (10.1016/j.molliq.2019.112156_bb0095) 2007; 28 Lin (10.1016/j.molliq.2019.112156_bb0185) 1996; 52 Chang (10.1016/j.molliq.2019.112156_bb0190) 1996; 24 Hofmann (10.1016/j.molliq.2019.112156_bb0085) 2006; 111 Kundu (10.1016/j.molliq.2019.112156_bb0090) 2013; 65 Pecere (10.1016/j.molliq.2019.112156_bb0180) 2000; 60 Moise (10.1016/j.molliq.2019.112156_bb0175) 1988; 319 Allen (10.1016/j.molliq.2019.112156_bb0005) 2004; 303 Sousa da Silva (10.1016/j.molliq.2019.112156_bb0265) 2012; 5 Goel (10.1016/j.molliq.2019.112156_bb0145) 2001; 172 Besler (10.1016/j.molliq.2019.112156_bb0215) 1990; 11 Wenk (10.1016/j.molliq.2019.112156_bb0065) 2011; 150 Pronk (10.1016/j.molliq.2019.112156_bb0250) 2013; 29 Duvoix (10.1016/j.molliq.2019.112156_bb0135) 2005; 223 Lee (10.1016/j.molliq.2019.112156_bb0050) 2015; 7 Rother (10.1016/j.molliq.2019.112156_bb0025) 2016; 45 Li (10.1016/j.molliq.2019.112156_bb0010) 2016; 1 Lozano-Pérez (10.1016/j.molliq.2019.112156_bb0125) 2017; 518 Darden (10.1016/j.molliq.2019.112156_bb0285) 1993; 98 Park (10.1016/j.molliq.2019.112156_bb0155) 2008; 46 Mark (10.1016/j.molliq.2019.112156_bb0275) 2001; 105 Pritchard (10.1016/j.molliq.2019.112156_bb0075) 2011; 8 Mathew (10.1016/j.molliq.2019.112156_bb0160) 2012; 7 Koh (10.1016/j.molliq.2019.112156_bb0100) 2015; 46 Bussi (10.1016/j.molliq.2019.112156_bb0290) 2007; 126 Wongpinyochit (10.1016/j.molliq.2019.112156_bb0195) 2019; 10 Showalter (10.1016/j.molliq.2019.112156_bb0270) 2007; 3 Martínez-Ballesta (10.1016/j.molliq.2019.112156_bb0240) 2016; 143 Leonarduzzi (10.1016/j.molliq.2019.112156_bb0030) 2010; 17 Chen (10.1016/j.molliq.2019.112156_bb0060) 2004; 126 Lee (10.1016/j.molliq.2019.112156_bb0140) 2009; 44 Subia (10.1016/j.molliq.2019.112156_bb0305) 2012; 24 Van Der Spoel (10.1016/j.molliq.2019.112156_bb0245) 2005; 26 Madhavi Sastry (10.1016/j.molliq.2019.112156_bb0225) 2013; 27 Li (10.1016/j.molliq.2019.112156_bb0115) 2017; 72 Yang (10.1016/j.molliq.2019.112156_bb0150) 2005; 280 Lozano-Pérez (10.1016/j.molliq.2019.112156_bb0200) 2015; 132 Lozano-Pérez (10.1016/j.molliq.2019.112156_bb0300) 2015; 44 Ordikhani (10.1016/j.molliq.2019.112156_bb0045) 2015; 26 Montalbán (10.1016/j.molliq.2019.112156_bb0120) 2018; 8 Mandal (10.1016/j.molliq.2019.112156_bb0080) 2009; 30 Navarro-Fernández (10.1016/j.molliq.2019.112156_bb0235) 2012; 55 Zuckerman (10.1016/j.molliq.2019.112156_bb0170) 1974; 44 He (10.1016/j.molliq.2019.112156_bb0220) 2012; 418 Singh (10.1016/j.molliq.2019.112156_bb0210) 1984; 5 Sercombe (10.1016/j.molliq.2019.112156_bb0020) 2015; 6 Gonçalves (10.1016/j.molliq.2019.112156_bb0040) 2016; 107 Lammel (10.1016/j.molliq.2019.112156_bb0110) 2010; 31 Maheshwari (10.1016/j.molliq.2019.112156_bb0165) 2006; 78 Bisht (10.1016/j.molliq.2019.112156_bb0055) 2016; 13 Zhang (10.1016/j.molliq.2019.112156_bb0205) 2007; 9 Hess (10.1016/j.molliq.2019.112156_bb0255) 2008; 4 Catto (10.1016/j.molliq.2019.112156_bb0105) 2015; 54 Hess (10.1016/j.molliq.2019.112156_bb0280) 1997; 18 Trott (10.1016/j.molliq.2019.112156_bb0230) 2010; 31 Berendsen (10.1016/j.molliq.2019.112156_bb0260) 1995; 91 Yoo (10.1016/j.molliq.2019.112156_bb0015) 2011; 10 Ak (10.1016/j.molliq.2019.112156_bb0130) 2008; 174 |
References_xml | – volume: 107 start-page: 160 year: 2016 ident: bb0040 publication-title: Eur. J. Pharm. Biopharm. contributor: fullname: Smirnova – volume: 1 start-page: 16071 year: 2016 ident: bb0010 publication-title: Nature Reviews Materials contributor: fullname: Mooney – volume: 18 start-page: 1463 year: 1997 ident: bb0280 publication-title: J. Comput. Chem. contributor: fullname: Fraaije – volume: 418 start-page: 197 year: 2012 ident: bb0220 publication-title: J. Mol. Biol. contributor: fullname: Zhou – volume: 7 start-page: e227 year: 2015 ident: bb0050 publication-title: Npg Asia Materials contributor: fullname: Rogers – volume: 52 start-page: 7182 year: 1981 ident: bb0295 publication-title: J. Appl. Phys. contributor: fullname: Rahman – volume: 46 start-page: 86 year: 2015 ident: bb0100 publication-title: Prog. Polym. Sci. contributor: fullname: Han – volume: 72 start-page: 394 year: 2017 ident: bb0115 publication-title: Mater. Sci. Eng. C contributor: fullname: Li – volume: 29 start-page: 845 year: 2013 end-page: 854 ident: bb0250 publication-title: Bioinformatics contributor: fullname: Lindahl – volume: 44 year: 2015 ident: bb0300 publication-title: Dalton Trans. contributor: fullname: Ruiz – volume: 44 year: 1974 ident: bb0170 publication-title: Obstet. Gynecol. contributor: fullname: Rubinstein – volume: 143 start-page: 318 year: 2016 ident: bb0240 publication-title: Colloids Surf. B: Biointerfaces contributor: fullname: Carvajal – volume: 8 start-page: 126 year: 2018 ident: bb0120 publication-title: Nanomaterials contributor: fullname: Kaplan – volume: 518 start-page: 11 year: 2017 ident: bb0125 publication-title: Int. J. Pharm. contributor: fullname: Cénis – volume: 52 start-page: 107 year: 1996 ident: bb0185 publication-title: J. Ethnopharmacol. contributor: fullname: Hattori – volume: 150 start-page: 128 year: 2011 ident: bb0065 publication-title: J. Control. Release contributor: fullname: Meinel – volume: 45 start-page: 6213 year: 2016 ident: bb0025 publication-title: Chem. Soc. Rev. contributor: fullname: Bruns – volume: 31 start-page: 4583 year: 2010 ident: bb0110 publication-title: Biomaterials contributor: fullname: Scheibel – volume: 31 start-page: 455 year: 2010 ident: bb0230 publication-title: J. Comput. Chem. contributor: fullname: Olson – volume: 4 start-page: 435 year: 2008 ident: bb0255 publication-title: J. Chem. Theory Comput. contributor: fullname: Lindahl – volume: 105 start-page: 9954 year: 2001 ident: bb0275 publication-title: J. Phys. Chem. A contributor: fullname: Nilsson – volume: 7 year: 2012 ident: bb0160 publication-title: PLoS One contributor: fullname: Kumar – volume: 174 start-page: 27 year: 2008 ident: bb0130 publication-title: Chem. Biol. Interact. contributor: fullname: Gülçin – volume: 172 start-page: 111 year: 2001 ident: bb0145 publication-title: Cancer Lett. contributor: fullname: Chauhan – volume: 126 start-page: 10044 year: 2004 ident: bb0060 publication-title: J. Am. Chem. Soc. contributor: fullname: Simanek – volume: 8 start-page: 797 year: 2011 ident: bb0075 publication-title: Expert Opinion on Drug Delivery contributor: fullname: Kaplan – volume: 9 start-page: 885 year: 2007 ident: bb0205 publication-title: J. Nanopart. Res. contributor: fullname: Wang – volume: 111 start-page: 219 year: 2006 ident: bb0085 publication-title: J. Control. Release contributor: fullname: Meinel – volume: 132 year: 2015 ident: bb0200 publication-title: J. Appl. Polym. Sci. contributor: fullname: Víllora – volume: 30 start-page: 2956 year: 2009 ident: bb0080 publication-title: Biomaterials contributor: fullname: Kundu – volume: 98 year: 1993 ident: bb0285 publication-title: J. Chem. Phys. contributor: fullname: Pedersen – volume: 91 start-page: 43 year: 1995 ident: bb0260 publication-title: Comput. Phys. Commun. contributor: fullname: van Drunen – volume: 46 start-page: 2881 year: 2008 ident: bb0155 publication-title: Food Chem. Toxicol. contributor: fullname: Sul – volume: 5 start-page: 367 year: 2012 ident: bb0265 publication-title: BMC Research Notes contributor: fullname: Vranken – volume: 24 year: 2012 ident: bb0305 publication-title: Nanotechnology contributor: fullname: Kundu – volume: 54 start-page: 101 year: 2015 ident: bb0105 publication-title: Mater. Sci. Eng. C contributor: fullname: Tanzi – volume: 303 start-page: 1818 year: 2004 ident: bb0005 publication-title: Science contributor: fullname: Cullis – volume: 26 start-page: 269 year: 2015 ident: bb0045 publication-title: J. Mater. Sci. Mater. Med. contributor: fullname: Simchi – volume: 44 start-page: 3195 year: 2009 ident: bb0140 publication-title: Eur. J. Med. Chem. contributor: fullname: Lajis – volume: 55 start-page: 6403 year: 2012 ident: bb0235 publication-title: J. Med. Chem. contributor: fullname: Wenzel – volume: 3 start-page: 961 year: 2007 ident: bb0270 publication-title: J. Chem. Theory Comput. contributor: fullname: Brüschweiler – volume: 126 year: 2007 ident: bb0290 publication-title: J. Chem. Phys. contributor: fullname: Parrinello – volume: 78 start-page: 2081 year: 2006 ident: bb0165 publication-title: Life Sci. contributor: fullname: Srimal – volume: 6 start-page: 286 year: 2015 ident: bb0020 publication-title: Front. Pharmacol. contributor: fullname: Hua – volume: 319 start-page: 327 year: 1988 ident: bb0175 publication-title: N. Engl. J. Med. contributor: fullname: Cano – volume: 10 start-page: 4278 year: 2019 ident: bb0195 publication-title: The Journal of Physical Chemistry Letters contributor: fullname: Seib – volume: 5 start-page: 129 year: 1984 ident: bb0210 publication-title: J. Comput. Chem. contributor: fullname: Kollman – volume: 32 start-page: 991 year: 2007 ident: bb0070 publication-title: Prog. Polym. Sci. contributor: fullname: Kaplan – volume: 26 start-page: 1701 year: 2005 ident: bb0245 publication-title: J. Comput. Chem. contributor: fullname: Berendsen – volume: 17 start-page: 74 year: 2010 ident: bb0030 publication-title: Curr. Med. Chem. contributor: fullname: Poli – start-page: 1 year: 2016 end-page: 5 ident: bb0310 article-title: 2016 9th Biomedical Engineering International Conference (BMEiCON) contributor: fullname: Damrongsakkul – volume: 28 start-page: 1643 year: 2007 ident: bb0095 publication-title: Biomaterials contributor: fullname: Gu – volume: 10 start-page: 521 year: 2011 ident: bb0015 publication-title: Nat. Rev. Drug Discov. contributor: fullname: Mitragotri – volume: 6 start-page: 73210 year: 2016 ident: bb0035 publication-title: RSC Adv. contributor: fullname: Kundu – volume: 24 start-page: 139 year: 1996 ident: bb0190 publication-title: The American Journal of Chinese Medicine contributor: fullname: Hattori – volume: 223 start-page: 181 year: 2005 ident: bb0135 publication-title: Cancer Lett. contributor: fullname: Diederich – volume: 27 start-page: 221 year: 2013 ident: bb0225 publication-title: J. Comput. Aided Mol. Des. contributor: fullname: Sherman – volume: 280 start-page: 5892 year: 2005 ident: bb0150 publication-title: J. Biol. Chem. contributor: fullname: Cole – volume: 11 start-page: 431 year: 1990 ident: bb0215 publication-title: J. Comput. Chem. contributor: fullname: Kollman – volume: 13 start-page: 953 year: 2016 ident: bb0055 publication-title: Expert Opinion on Drug Delivery contributor: fullname: Rupenthal – volume: 60 start-page: 2800 year: 2000 ident: bb0180 publication-title: Cancer Res. contributor: fullname: Palù – volume: 65 start-page: 457 year: 2013 ident: bb0090 publication-title: Adv. Drug Deliv. Rev. contributor: fullname: Wang – volume: 143 start-page: 318 year: 2016 ident: 10.1016/j.molliq.2019.112156_bb0240 publication-title: Colloids Surf. B: Biointerfaces doi: 10.1016/j.colsurfb.2016.03.056 contributor: fullname: Martínez-Ballesta – volume: 107 start-page: 160 year: 2016 ident: 10.1016/j.molliq.2019.112156_bb0040 publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2016.07.003 contributor: fullname: Gonçalves – volume: 30 start-page: 2956 year: 2009 ident: 10.1016/j.molliq.2019.112156_bb0080 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2009.02.006 contributor: fullname: Mandal – volume: 26 start-page: 269 year: 2015 ident: 10.1016/j.molliq.2019.112156_bb0045 publication-title: J. Mater. Sci. Mater. Med. doi: 10.1007/s10856-015-5606-0 contributor: fullname: Ordikhani – volume: 52 start-page: 107 year: 1996 ident: 10.1016/j.molliq.2019.112156_bb0185 publication-title: J. Ethnopharmacol. doi: 10.1016/0378-8741(96)01397-9 contributor: fullname: Lin – volume: 18 start-page: 1463 year: 1997 ident: 10.1016/j.molliq.2019.112156_bb0280 publication-title: J. Comput. Chem. doi: 10.1002/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H contributor: fullname: Hess – volume: 174 start-page: 27 year: 2008 ident: 10.1016/j.molliq.2019.112156_bb0130 publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2008.05.003 contributor: fullname: Ak – volume: 150 start-page: 128 year: 2011 ident: 10.1016/j.molliq.2019.112156_bb0065 publication-title: J. Control. Release doi: 10.1016/j.jconrel.2010.11.007 contributor: fullname: Wenk – volume: 65 start-page: 457 year: 2013 ident: 10.1016/j.molliq.2019.112156_bb0090 publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2012.09.043 contributor: fullname: Kundu – volume: 24 start-page: 139 year: 1996 ident: 10.1016/j.molliq.2019.112156_bb0190 publication-title: The American Journal of Chinese Medicine doi: 10.1142/S0192415X96000189 contributor: fullname: Chang – volume: 105 start-page: 9954 year: 2001 ident: 10.1016/j.molliq.2019.112156_bb0275 publication-title: J. Phys. Chem. A doi: 10.1021/jp003020w contributor: fullname: Mark – volume: 10 start-page: 4278 year: 2019 ident: 10.1016/j.molliq.2019.112156_bb0195 publication-title: The Journal of Physical Chemistry Letters doi: 10.1021/acs.jpclett.9b01591 contributor: fullname: Wongpinyochit – volume: 29 start-page: 845 year: 2013 ident: 10.1016/j.molliq.2019.112156_bb0250 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt055 contributor: fullname: Pronk – volume: 8 start-page: 797 year: 2011 ident: 10.1016/j.molliq.2019.112156_bb0075 publication-title: Expert Opinion on Drug Delivery doi: 10.1517/17425247.2011.568936 contributor: fullname: Pritchard – volume: 44 year: 2015 ident: 10.1016/j.molliq.2019.112156_bb0300 publication-title: Dalton Trans. doi: 10.1039/C5DT00378D contributor: fullname: Lozano-Pérez – volume: 132 year: 2015 ident: 10.1016/j.molliq.2019.112156_bb0200 publication-title: J. Appl. Polym. Sci. doi: 10.1002/app.41702 contributor: fullname: Lozano-Pérez – volume: 10 start-page: 521 year: 2011 ident: 10.1016/j.molliq.2019.112156_bb0015 publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd3499 contributor: fullname: Yoo – volume: 7 start-page: e227 year: 2015 ident: 10.1016/j.molliq.2019.112156_bb0050 publication-title: Npg Asia Materials doi: 10.1038/am.2015.114 contributor: fullname: Lee – volume: 46 start-page: 2881 year: 2008 ident: 10.1016/j.molliq.2019.112156_bb0155 publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2008.05.030 contributor: fullname: Park – volume: 6 start-page: 286 year: 2015 ident: 10.1016/j.molliq.2019.112156_bb0020 publication-title: Front. Pharmacol. doi: 10.3389/fphar.2015.00286 contributor: fullname: Sercombe – volume: 9 start-page: 885 year: 2007 ident: 10.1016/j.molliq.2019.112156_bb0205 publication-title: J. Nanopart. Res. doi: 10.1007/s11051-006-9162-x contributor: fullname: Zhang – volume: 303 start-page: 1818 year: 2004 ident: 10.1016/j.molliq.2019.112156_bb0005 publication-title: Science doi: 10.1126/science.1095833 contributor: fullname: Allen – volume: 26 start-page: 1701 year: 2005 ident: 10.1016/j.molliq.2019.112156_bb0245 publication-title: J. Comput. Chem. doi: 10.1002/jcc.20291 contributor: fullname: Van Der Spoel – volume: 32 start-page: 991 year: 2007 ident: 10.1016/j.molliq.2019.112156_bb0070 publication-title: Prog. Polym. Sci. doi: 10.1016/j.progpolymsci.2007.05.013 contributor: fullname: Vepari – volume: 126 year: 2007 ident: 10.1016/j.molliq.2019.112156_bb0290 publication-title: J. Chem. Phys. doi: 10.1063/1.2408420 contributor: fullname: Bussi – volume: 24 year: 2012 ident: 10.1016/j.molliq.2019.112156_bb0305 publication-title: Nanotechnology contributor: fullname: Subia – volume: 3 start-page: 961 year: 2007 ident: 10.1016/j.molliq.2019.112156_bb0270 publication-title: J. Chem. Theory Comput. doi: 10.1021/ct7000045 contributor: fullname: Showalter – volume: 31 start-page: 4583 year: 2010 ident: 10.1016/j.molliq.2019.112156_bb0110 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2010.02.024 contributor: fullname: Lammel – volume: 78 start-page: 2081 year: 2006 ident: 10.1016/j.molliq.2019.112156_bb0165 publication-title: Life Sci. doi: 10.1016/j.lfs.2005.12.007 contributor: fullname: Maheshwari – volume: 91 start-page: 43 year: 1995 ident: 10.1016/j.molliq.2019.112156_bb0260 publication-title: Comput. Phys. Commun. doi: 10.1016/0010-4655(95)00042-E contributor: fullname: Berendsen – start-page: 1 year: 2016 ident: 10.1016/j.molliq.2019.112156_bb0310 contributor: fullname: Kongton – volume: 31 start-page: 455 year: 2010 ident: 10.1016/j.molliq.2019.112156_bb0230 publication-title: J. Comput. Chem. doi: 10.1002/jcc.21334 contributor: fullname: Trott – volume: 98 year: 1993 ident: 10.1016/j.molliq.2019.112156_bb0285 publication-title: J. Chem. Phys. doi: 10.1063/1.464397 contributor: fullname: Darden – volume: 52 start-page: 7182 year: 1981 ident: 10.1016/j.molliq.2019.112156_bb0295 publication-title: J. Appl. Phys. doi: 10.1063/1.328693 contributor: fullname: Parrinello – volume: 172 start-page: 111 year: 2001 ident: 10.1016/j.molliq.2019.112156_bb0145 publication-title: Cancer Lett. doi: 10.1016/S0304-3835(01)00655-3 contributor: fullname: Goel – volume: 5 start-page: 129 year: 1984 ident: 10.1016/j.molliq.2019.112156_bb0210 publication-title: J. Comput. Chem. doi: 10.1002/jcc.540050204 contributor: fullname: Singh – volume: 55 start-page: 6403 year: 2012 ident: 10.1016/j.molliq.2019.112156_bb0235 publication-title: J. Med. Chem. doi: 10.1021/jm300621j contributor: fullname: Navarro-Fernández – volume: 1 start-page: 16071 year: 2016 ident: 10.1016/j.molliq.2019.112156_bb0010 publication-title: Nature Reviews Materials doi: 10.1038/natrevmats.2016.71 contributor: fullname: Li – volume: 6 start-page: 73210 year: 2016 ident: 10.1016/j.molliq.2019.112156_bb0035 publication-title: RSC Adv. doi: 10.1039/C6RA12491G contributor: fullname: Mukhopadhyay – volume: 280 start-page: 5892 year: 2005 ident: 10.1016/j.molliq.2019.112156_bb0150 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M404751200 contributor: fullname: Yang – volume: 46 start-page: 86 year: 2015 ident: 10.1016/j.molliq.2019.112156_bb0100 publication-title: Prog. Polym. Sci. doi: 10.1016/j.progpolymsci.2015.02.001 contributor: fullname: Koh – volume: 44 year: 1974 ident: 10.1016/j.molliq.2019.112156_bb0170 publication-title: Obstet. Gynecol. contributor: fullname: Zuckerman – volume: 45 start-page: 6213 year: 2016 ident: 10.1016/j.molliq.2019.112156_bb0025 publication-title: Chem. Soc. Rev. doi: 10.1039/C6CS00177G contributor: fullname: Rother – volume: 7 year: 2012 ident: 10.1016/j.molliq.2019.112156_bb0160 publication-title: PLoS One contributor: fullname: Mathew – volume: 518 start-page: 11 year: 2017 ident: 10.1016/j.molliq.2019.112156_bb0125 publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2016.12.046 contributor: fullname: Lozano-Pérez – volume: 54 start-page: 101 year: 2015 ident: 10.1016/j.molliq.2019.112156_bb0105 publication-title: Mater. Sci. Eng. C doi: 10.1016/j.msec.2015.05.003 contributor: fullname: Catto – volume: 126 start-page: 10044 year: 2004 ident: 10.1016/j.molliq.2019.112156_bb0060 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja048548j contributor: fullname: Chen – volume: 60 start-page: 2800 year: 2000 ident: 10.1016/j.molliq.2019.112156_bb0180 publication-title: Cancer Res. contributor: fullname: Pecere – volume: 11 start-page: 431 year: 1990 ident: 10.1016/j.molliq.2019.112156_bb0215 publication-title: J. Comput. Chem. doi: 10.1002/jcc.540110404 contributor: fullname: Besler – volume: 13 start-page: 953 year: 2016 ident: 10.1016/j.molliq.2019.112156_bb0055 publication-title: Expert Opinion on Drug Delivery doi: 10.1517/17425247.2016.1163334 contributor: fullname: Bisht – volume: 223 start-page: 181 year: 2005 ident: 10.1016/j.molliq.2019.112156_bb0135 publication-title: Cancer Lett. doi: 10.1016/j.canlet.2004.09.041 contributor: fullname: Duvoix – volume: 28 start-page: 1643 year: 2007 ident: 10.1016/j.molliq.2019.112156_bb0095 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2006.12.004 contributor: fullname: Yang – volume: 319 start-page: 327 year: 1988 ident: 10.1016/j.molliq.2019.112156_bb0175 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198808113190602 contributor: fullname: Moise – volume: 72 start-page: 394 year: 2017 ident: 10.1016/j.molliq.2019.112156_bb0115 publication-title: Mater. Sci. Eng. C doi: 10.1016/j.msec.2016.11.085 contributor: fullname: Li – volume: 5 start-page: 367 year: 2012 ident: 10.1016/j.molliq.2019.112156_bb0265 publication-title: BMC Research Notes doi: 10.1186/1756-0500-5-367 contributor: fullname: Sousa da Silva – volume: 418 start-page: 197 year: 2012 ident: 10.1016/j.molliq.2019.112156_bb0220 publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2012.02.040 contributor: fullname: He – volume: 4 start-page: 435 year: 2008 ident: 10.1016/j.molliq.2019.112156_bb0255 publication-title: J. Chem. Theory Comput. doi: 10.1021/ct700301q contributor: fullname: Hess – volume: 8 start-page: 126 year: 2018 ident: 10.1016/j.molliq.2019.112156_bb0120 publication-title: Nanomaterials doi: 10.3390/nano8020126 contributor: fullname: Montalbán – volume: 27 start-page: 221 year: 2013 ident: 10.1016/j.molliq.2019.112156_bb0225 publication-title: J. Comput. Aided Mol. Des. doi: 10.1007/s10822-013-9644-8 contributor: fullname: Madhavi Sastry – volume: 17 start-page: 74 year: 2010 ident: 10.1016/j.molliq.2019.112156_bb0030 publication-title: Curr. Med. Chem. doi: 10.2174/092986710789957760 contributor: fullname: Leonarduzzi – volume: 111 start-page: 219 year: 2006 ident: 10.1016/j.molliq.2019.112156_bb0085 publication-title: J. Control. Release doi: 10.1016/j.jconrel.2005.12.009 contributor: fullname: Hofmann – volume: 44 start-page: 3195 year: 2009 ident: 10.1016/j.molliq.2019.112156_bb0140 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2009.03.020 contributor: fullname: Lee |
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Snippet | Recent emergence of natural biopolymers as drug delivery vehicles is attributed to their biodegradability and less systemic toxicity. Here, we have synthesized... |
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Title | Molecular insight into silk fibroin based delivery vehicle for amphiphilic drugs: Synthesis, characterization and molecular dynamics studies |
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