Implications of hypocobalaminemia as a negative prognostic marker in juvenile dogs with parvovirus enteritis
Canine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum cobalamin (CBL) concentrations, is a recognized complication in chronic enteropathies in adult dogs but remains poorly understood in the context of acute ente...
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| Published in | Frontiers in veterinary science Vol. 11; p. 1426664 |
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| Language | English |
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16.07.2024
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| Abstract | Canine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum cobalamin (CBL) concentrations, is a recognized complication in chronic enteropathies in adult dogs but remains poorly understood in the context of acute enteropathies, especially in young dogs. The aim of this study was to investigate the frequency and severity of hypocobalaminemia in young dogs with parvovirus enteritis and evaluation of CBL as a predictor of outcome.
Thirty client-owned dogs diagnosed with parvovirus infection and thirty healthy controls were enrolled. Clinical, hematological, and biochemical tests, including CBL and serum methylmalonic acid (MMA) concentrations, were assessed.
Results indicated a significantly higher prevalence of hypocobalaminemia in dogs with parvovirus enteritis compared to healthy controls, as well as a significant correlation with a disease severity score. Moreover, survivors demonstrated higher CBL concentrations than non-survivors, suggesting an eventual prognostic value of CBL status. However, parenteral CBL supplementation showed no significant effect on serum CBL or MMA concentrations, highlighting potential challenges in CBL uptake at the cellular level.
Hypocobalaminemia in this population is caused by multiple factors such as reduced nutritional absorption, gastrointestinal losses, and increased metabolic demands. Further research is needed to develop tailored management strategies, evaluate the effectiveness of CBL supplementation, and understand the mechanisms behind hypocobalaminemia in parvovirus infection. |
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| AbstractList | Canine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum cobalamin (CBL) concentrations, is a recognized complication in chronic enteropathies in adult dogs but remains poorly understood in the context of acute enteropathies, especially in young dogs. The aim of this study was to investigate the frequency and severity of hypocobalaminemia in young dogs with parvovirus enteritis and evaluation of CBL as a predictor of outcome.
Thirty client-owned dogs diagnosed with parvovirus infection and thirty healthy controls were enrolled. Clinical, hematological, and biochemical tests, including CBL and serum methylmalonic acid (MMA) concentrations, were assessed.
Results indicated a significantly higher prevalence of hypocobalaminemia in dogs with parvovirus enteritis compared to healthy controls, as well as a significant correlation with a disease severity score. Moreover, survivors demonstrated higher CBL concentrations than non-survivors, suggesting an eventual prognostic value of CBL status. However, parenteral CBL supplementation showed no significant effect on serum CBL or MMA concentrations, highlighting potential challenges in CBL uptake at the cellular level.
Hypocobalaminemia in this population is caused by multiple factors such as reduced nutritional absorption, gastrointestinal losses, and increased metabolic demands. Further research is needed to develop tailored management strategies, evaluate the effectiveness of CBL supplementation, and understand the mechanisms behind hypocobalaminemia in parvovirus infection. Canine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum cobalamin (CBL) concentrations, is a recognized complication in chronic enteropathies in adult dogs but remains poorly understood in the context of acute enteropathies, especially in young dogs. The aim of this study was to investigate the frequency and severity of hypocobalaminemia in young dogs with parvovirus enteritis and evaluation of CBL as a predictor of outcome.IntroductionCanine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum cobalamin (CBL) concentrations, is a recognized complication in chronic enteropathies in adult dogs but remains poorly understood in the context of acute enteropathies, especially in young dogs. The aim of this study was to investigate the frequency and severity of hypocobalaminemia in young dogs with parvovirus enteritis and evaluation of CBL as a predictor of outcome.Thirty client-owned dogs diagnosed with parvovirus infection and thirty healthy controls were enrolled. Clinical, hematological, and biochemical tests, including CBL and serum methylmalonic acid (MMA) concentrations, were assessed.Materials and methodsThirty client-owned dogs diagnosed with parvovirus infection and thirty healthy controls were enrolled. Clinical, hematological, and biochemical tests, including CBL and serum methylmalonic acid (MMA) concentrations, were assessed.Results indicated a significantly higher prevalence of hypocobalaminemia in dogs with parvovirus enteritis compared to healthy controls, as well as a significant correlation with a disease severity score. Moreover, survivors demonstrated higher CBL concentrations than non-survivors, suggesting an eventual prognostic value of CBL status. However, parenteral CBL supplementation showed no significant effect on serum CBL or MMA concentrations, highlighting potential challenges in CBL uptake at the cellular level.ResultsResults indicated a significantly higher prevalence of hypocobalaminemia in dogs with parvovirus enteritis compared to healthy controls, as well as a significant correlation with a disease severity score. Moreover, survivors demonstrated higher CBL concentrations than non-survivors, suggesting an eventual prognostic value of CBL status. However, parenteral CBL supplementation showed no significant effect on serum CBL or MMA concentrations, highlighting potential challenges in CBL uptake at the cellular level.Hypocobalaminemia in this population is caused by multiple factors such as reduced nutritional absorption, gastrointestinal losses, and increased metabolic demands. Further research is needed to develop tailored management strategies, evaluate the effectiveness of CBL supplementation, and understand the mechanisms behind hypocobalaminemia in parvovirus infection.DiscussionHypocobalaminemia in this population is caused by multiple factors such as reduced nutritional absorption, gastrointestinal losses, and increased metabolic demands. Further research is needed to develop tailored management strategies, evaluate the effectiveness of CBL supplementation, and understand the mechanisms behind hypocobalaminemia in parvovirus infection. Introduction Canine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum cobalamin (CBL) concentrations, is a recognized complication in chronic enteropathies in adult dogs but remains poorly understood in the context of acute enteropathies, especially in young dogs. The aim of this study was to investigate the frequency and severity of hypocobalaminemia in young dogs with parvovirus enteritis and evaluation of CBL as a predictor of outcome. Materials and methods Thirty client-owned dogs diagnosed with parvovirus infection and thirty healthy controls were enrolled. Clinical, hematological, and biochemical tests, including CBL and serum methylmalonic acid (MMA) concentrations, were assessed. Results Results indicated a significantly higher prevalence of hypocobalaminemia in dogs with parvovirus enteritis compared to healthy controls, as well as a significant correlation with a disease severity score. Moreover, survivors demonstrated higher CBL concentrations than non-survivors, suggesting an eventual prognostic value of CBL status. However, parenteral CBL supplementation showed no significant effect on serum CBL or MMA concentrations, highlighting potential challenges in CBL uptake at the cellular level. Discussion Hypocobalaminemia in this population is caused by multiple factors such as reduced nutritional absorption, gastrointestinal losses, and increased metabolic demands. Further research is needed to develop tailored management strategies, evaluate the effectiveness of CBL supplementation, and understand the mechanisms behind hypocobalaminemia in parvovirus infection. IntroductionCanine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum cobalamin (CBL) concentrations, is a recognized complication in chronic enteropathies in adult dogs but remains poorly understood in the context of acute enteropathies, especially in young dogs. The aim of this study was to investigate the frequency and severity of hypocobalaminemia in young dogs with parvovirus enteritis and evaluation of CBL as a predictor of outcome.Materials and methodsThirty client-owned dogs diagnosed with parvovirus infection and thirty healthy controls were enrolled. Clinical, hematological, and biochemical tests, including CBL and serum methylmalonic acid (MMA) concentrations, were assessed.ResultsResults indicated a significantly higher prevalence of hypocobalaminemia in dogs with parvovirus enteritis compared to healthy controls, as well as a significant correlation with a disease severity score. Moreover, survivors demonstrated higher CBL concentrations than non-survivors, suggesting an eventual prognostic value of CBL status. However, parenteral CBL supplementation showed no significant effect on serum CBL or MMA concentrations, highlighting potential challenges in CBL uptake at the cellular level.DiscussionHypocobalaminemia in this population is caused by multiple factors such as reduced nutritional absorption, gastrointestinal losses, and increased metabolic demands. Further research is needed to develop tailored management strategies, evaluate the effectiveness of CBL supplementation, and understand the mechanisms behind hypocobalaminemia in parvovirus infection. |
| Author | Tichy, Alexander Giani, Bettina Doulidis, Pavlos G Schwendenwein, Ilse Plickert, Hanna D Luckschander-Zeller, Nicole Marculescu, Rodrig Burgener, Iwan A |
| AuthorAffiliation | 3 Department for Biomedical Sciences, University of Veterinary Medicine of Vienna , Vienna , Austria 4 Clinical Institute for Laboratory Medicine, Medical University of Vienna , Vienna , Austria 2 Tierklinik Parndorf , Parndorf , Austria 1 Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna , Vienna , Austria 5 Central Laboratory, Department for Pathobiology, University of Veterinary Medicine of Vienna , Vienna , Austria |
| AuthorAffiliation_xml | – name: 3 Department for Biomedical Sciences, University of Veterinary Medicine of Vienna , Vienna , Austria – name: 1 Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna , Vienna , Austria – name: 5 Central Laboratory, Department for Pathobiology, University of Veterinary Medicine of Vienna , Vienna , Austria – name: 4 Clinical Institute for Laboratory Medicine, Medical University of Vienna , Vienna , Austria – name: 2 Tierklinik Parndorf , Parndorf , Austria |
| Author_xml | – sequence: 1 givenname: Nicole surname: Luckschander-Zeller fullname: Luckschander-Zeller, Nicole organization: Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna, Vienna, Austria – sequence: 2 givenname: Bettina surname: Giani fullname: Giani, Bettina organization: Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna, Vienna, Austria – sequence: 3 givenname: Pavlos G surname: Doulidis fullname: Doulidis, Pavlos G organization: Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna, Vienna, Austria – sequence: 4 givenname: Hanna D surname: Plickert fullname: Plickert, Hanna D organization: Tierklinik Parndorf, Parndorf, Austria – sequence: 5 givenname: Alexander surname: Tichy fullname: Tichy, Alexander organization: Department for Biomedical Sciences, University of Veterinary Medicine of Vienna, Vienna, Austria – sequence: 6 givenname: Rodrig surname: Marculescu fullname: Marculescu, Rodrig organization: Clinical Institute for Laboratory Medicine, Medical University of Vienna, Vienna, Austria – sequence: 7 givenname: Ilse surname: Schwendenwein fullname: Schwendenwein, Ilse organization: Central Laboratory, Department for Pathobiology, University of Veterinary Medicine of Vienna, Vienna, Austria – sequence: 8 givenname: Iwan A surname: Burgener fullname: Burgener, Iwan A organization: Department for Companion Animals and Horses, Division of Small Animal Internal Medicine, University of Veterinary Medicine of Vienna, Vienna, Austria |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39086759$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/jvim.15638 10.1111/j.1939-1676.2010.0552.x 10.3390/nu13020546 10.1016/j.tvjl.2013.01.025 10.1016/s0378-1135(99)00084-x 10.2460/javma.21.05.0240 10.1016/j.tvjl.2013.03.022 10.1203/00006450-199101000-00006 10.1892/0891-6640(2007)21[700:CEIDEO]2.0.CO;2 10.3390/nu12092867 10.1111/j.1748-5827.2005.tb00330.x 10.3945/an.117.015628 10.1093/carcin/19.7.1163 10.2460/ajvr.73.8.1194 10.1111/jvim.15348 10.2147/VMRR.S80971 10.1016/1040-8428(94)90022-1 10.1111/jvim.15090 10.1016/S0027-5107(01)00168-3 10.3390/ani13081378 10.1182/blood-2003-08-2852 10.5326/JAAHA-MS-6195 10.1136/vr.115.18.453 10.1016/j.cvsm.2020.07.008 10.1152/ajpgi.1981.241.4.G294 10.1111/jsap.13699 10.1016/j.ijdevneu.2009.03.005 10.1016/j.cca.2021.12.015 10.1111/jvim.14739 10.1099/0022-1317-82-12-3021 10.1084/jem.20220057 10.1152/ajpgi.1989.257.3.G344 10.1111/jvim.15065 10.1111/j.1748-5827.2004.tb00245.x 10.1016/j.tvjl.2013.02.002 10.2460/ajvr.74.1.84 10.1111/jvim.16736 10.1371/journal.pone.0192198 10.1111/j.1748-5827.2000.tb03233.x 10.1016/j.jnutbio.2005.01.018 10.1111/j.1534-6935.2004.04020.x 10.1016/S0014-4886(03)00113-4 10.1177/147323000703500313 10.1111/jvim.14597 10.1096/fasebj.7.14.7901104 |
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| Keywords | cobalamin (CBL) methylmalonic acid canine parvoviral enteritis outcome |
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| Snippet | Canine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum cobalamin (CBL)... Introduction Canine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum... IntroductionCanine Parvovirus 2 (CPV-2) infection poses a significant global health risk to susceptible dogs. Hypocobalaminemia, defined as reduced serum... |
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| Title | Implications of hypocobalaminemia as a negative prognostic marker in juvenile dogs with parvovirus enteritis |
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